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dc.contributor.authorFerron, Artur Junio Togneri
dc.contributor.authorJacobsen, Bruno Barcellos
dc.contributor.authorSant'Ana, Paula Grippa [UNESP]
dc.contributor.authorCampos, Dijon Henrique Salomé de [UNESP]
dc.contributor.authorTomasi, Loreta Casquel de [UNESP]
dc.contributor.authorLuvizotto, Renata de Azevedo Mello
dc.contributor.authorCicogna, Antonio Carlos [UNESP]
dc.contributor.authorLeopoldo, André Soares
dc.contributor.authorLima-Leopoldo, Ana Paula
dc.date.accessioned2015-12-07T15:31:29Z
dc.date.available2015-12-07T15:31:29Z
dc.date.issued2015
dc.identifierhttp://dx.doi.org/10.1371/journal.pone.0138605
dc.identifier.citationPlos One, v. 10, n. 9, 2015.
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/11449/131088
dc.description.abstractObesity has been shown to impair myocardial performance. Some factors have been suggested as responsible for possible cardiac abnormalities in models of obesity, among them beta-adrenergic (βA) system, an important mechanism of regulation of myocardial contraction and relaxation. The objective of present study was to evaluate the involvement of βA system components in myocardial dysfunction induced by obesity. Thirty-day-old male Wistar rats were distributed in control (C, n = 25) and obese (Ob, n = 25) groups. The C group was fed a standard diet and Ob group was fed four unsaturated high-fat diets for 15 weeks. Cardiac function was evaluated by isolated papillary muscle preparation and βA system evaluated by using cumulative concentrations of isoproterenol and Western blot. After 15 weeks, the Ob rats developed higher adiposity index than C rats and several comorbidities; however, were not associated with changes in systolic blood pressure. Obesity caused structural changes and the myocardial responsiveness to post-rest contraction stimulus and increased extracellular calcium (Ca2+) was compromised. There were no changes in cardiac function between groups after βA stimulation. The obesity was not accompanied by changes in protein expression of G protein subunit alpha (Gsα) and βA receptors (β1AR and β2AR). In conclusion, the myocardial dysfunction caused by unsaturated high-fat diet-induced obesity, after 15 weeks, is not related to βAR system impairment at the receptor-signalling pathway.en
dc.description.sponsorshipFundação de Apoio à Pesquisa e Estudos na Área da Saúde (FAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.language.isoeng
dc.publisherPublic Library Science
dc.relation.ispartofPlos One
dc.sourcePubMed
dc.titleCardiac dysfunction induced by obesity es not related to beta-adrenergic system impairment at the receptor-signalling pathwayen
dc.typeArtigo
dcterms.rightsHolderPublic Library Science
dc.contributor.institutionUniversidade Federal do Espírito Santo (UFES)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal do Mato Grosso (UFMT)
dc.description.affiliationCenter of Physical Education and Sports, Department of Sports, Federal University of Espírito Santo, Vitória, Espírito Santo, Brazil
dc.description.affiliationDepartment of Clinical and Cardiology, School of Medicine, UNESP- Univ. Estadual Paulista, Botucatu, São Paulo, Brazil
dc.description.affiliationInstituto de Ciências da Saúde, Federal University of Mato Grosso, Sinop, Mato Grosso, Brazil
dc.description.affiliationUnespDepartment of Clinical and Cardiology, School of Medicine, UNESP- Univ. Estadual Paulista, Botucatu, São Paulo, Brazil
dc.identifier.doi10.1371/journal.pone.0138605
dc.rights.accessRightsAcesso aberto
dc.description.sponsorshipIdFAPES: 53618009/2011
dc.description.sponsorshipIdFAPESP: 2012/16647-0
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt
dc.identifier.filePMC4577087.pdf
dc.identifier.lattes9418970103564137
dc.identifier.pubmed26390297
dc.identifier.pmcPMC4577087
unesp.author.lattes9418970103564137[7]
unesp.author.orcid0000-0002-4402-6523[7]
dc.relation.ispartofjcr2.766
dc.relation.ispartofsjr1,164
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