• Bisphenol a and mesenchymal stem cells: Recent insights 

  Nunes, Helga Caputo ; Scarano, Wellerson Rodrigo ; Deffune, Elenice ; Felisbino, Sérgio Luis ; Porreca, Immacolata; Delella, Flávia Karina (Life Sciences, 2018) [Resenha]

  Mesenchymal stem cells (MSCs) are found in all adult mesenchymal tissues. They play a role in the maintenance of tissue homeostasis and repair by allowing renewal of the cellular stock. MSCs can be isolated from both human ...

• Multiple Tolerization Reduces Antibody Binding Against Tolerogen Cells: Implications for the Production of Monoclonal Antibodies 

  De Almeida, Rodrigo ; Nakamura, Cecília Naomi ; De Lima Fontes, Marina ; Da Silva, Julia Paiola ; Bertanha, Matheus ; Deffune, Elenice ; Fusco-Almeida, Ana Marisa ; Moroz, Andrei (Monoclonal Antibodies in Immunodiagnosis and Immunotherapy, 2018) [Artigo]

  We report an immunization technique that can update the production of monoclonal antibodies (mAbs): the multiple tolerization subtractive immunization (MTSI). A total of 10 BALB/C mice were used. Animals in group 1 received ...

• Association of UGT2B7, UGT1A9, ABCG2, and IL23R polymorphisms with rejection risk in kidney transplant patients 

  Cilião, Heloísa Lizotti; Camargo-Godoy, Rossana Batista Oliveira; de Souza, Marilesia Ferreira; dos Reis, Mariana Bisarro ; Iastrenski, Lorena; Alvares Delfino, Vinicius Daher; Rogatto, Silvia Regina ; de Syllos Cólus, Ilce Mara (Journal of Toxicology and Environmental Health - Part A: Current Issues, 2017) [Artigo]

  Despite advances in testing compatibility between donor and recipient, graft rejection remains a current concern. Single-nucleotide polymorphisms (SNPs) that codify altered enzymes of metabolism, drug transport, and the ...

• Prognostic Classifier Based on Genome-Wide DNA Methylation Profiling in Well-Differentiated Thyroid Tumors 

  Bisarro Dos Reis, Mariana; Barros-Filho, Mateus Camargo; Marchi, Fábio Albuquerque; Beltrami, Caroline Moraes; Kuasne, Hellen; Pinto, Clóvis Antônio Lopes; Ambatipudi, Srikant; Herceg, Zdenko; Kowalski, Luiz Paulo; Rogatto, Silvia Regina (The Journal of clinical endocrinology and metabolism, 2017) [Artigo]

  Context: Even though the majority of well-differentiated thyroid carcinoma (WDTC) is indolent, a number of cases display an aggressive behavior. Cumulative evidence suggests that the deregulation of DNA methylation has the ...

• Nuclear loss and cytoplasmic expression of androgen receptor in penile carcinomas: role as a driver event and as a prognosis factor 

  Kuasne, Hellen ; Barros-Filho, Mateus C.; Marchi, Fábio A.; Drigo, Sandra A. ; Scapulatempo-Neto, Cristovam; Faria, Eliney F.; Rogatto, Silvia R. (Virchows Archiv, 2018) [Artigo]

  Androgen receptor (AR) is a member of the steroid and nuclear family receptor that acts as transcription factor. AR signaling plays pivotal role in the development and progression of prostate cancer. However, the role of ...

• Immunosensors made with layer-by-layer films on chitosan/gold nanoparticle matrices to detect d-dimer as biomarker for venous thromboembolism 

  Rodrigues, Valquiria C.; Moraes, Marli L.; Soares, Juliana C.; Soares, Andrey C.; Sanfelice, Rafaela; Deffune, Elenice ; Oliveira, Osvaldo N. (Bulletin of the Chemical Society of Japan, 2018) [Artigo]

  We report on immunosensors to detect D-dimer, a biomarker of venous thromboembolism, which are made with layer-bylayer (LbL) films containing immobilized anti-D-dimer monoclonal antibody alternated with a layer of chitosan/gold ...

• Culture of mesenchymal stem cells derived from equine synovial membrane in alginate hydrogel microcapsules 

  Santos, Vitor Hugo ; Pfeifer, João Pedro Hübbe ; de Souza, Jaqueline Brandão ; Milani, Betsabéia Heloisa Gentilha ; de Oliveira, Rogério Antonio ; Assis, Marjorie Golim ; Deffune, Elenice ; Moroz, Andrei ; Alves, Ana Liz Garcia (BMC Veterinary Research, 2018) [Artigo]

  Background: Mesenchymal stem cells derived from the synovial membrane (MSCSM) have a greater potential for joint regeneration, besides the capacity for chondrogenic differentiation, since they are a source closer to the ...

• Ultrastructural analysis and residual DNA evaluation of rabbit vein scaffold 

  Bertanha, Matheus ; Sobreira, Marcone Lima ; Bovolato, Ana Lívia de Carvalho ; Rinaldi, Jaqueline de Carvalho ; Reis, Patricia Pintor ; Moroz, Andrei ; de Moraes, Leonardo Nazario ; Deffune, Elenice (Acta Cirurgica Brasileira, 2017) [Artigo]

  Purpose: To investigate the ultrastructural characteristics and analysis of residual DNA in scaffold models, produced with decellularized vena cava in an experimental model with rabbits. Methods: Three groups were created ...

• Multidimensional integrative analysis uncovers driver candidates and biomarkers in penile carcinoma 

  Marchi, Fabio Albuquerque; Martins, David Correa; Barros-Filho, Mateus Camargo; Kuasne, Hellen; Busso Lopes, Ariane Fidelis; Brentani, Helena; Trindade Filho, Jose Carlos Souza ; Guimarães, Gustavo Cardoso; Faria, Eliney F.; Scapulatempo-Neto, Cristovam et al. (Scientific Reports, 2017) [Artigo]

  Molecular data generation and their combination in penile carcinomas (PeCa), a significant public health problem in poor and underdeveloped countries, remain virtually unexplored. An integrativemethodology combin ing ...

• Fibrin gel versus papain gel in the healing of chronic venous ulcers: A double-blind randomized controlled trial 

  de Araújo, Illymack CF ; Defune, Elenice ; Abbade, Luciana PF ; Miot, Hélio A ; Bertanha, Matheus ; de Carvalho, Lídia R ; Ferreira, Rosana R ; Yoshida, Winston B (Phlebology, 2017) [Artigo]

  Objectives: Compare the efficacy and safety of fibrin gel to 8% papain gel for wound dressing of venous ulcers. Method: Patients with chronic venous ulcers were randomly assigned to one in three groups: Group 1—fibrin gel; ...

• HABP2 p. G534E variant in patients with family history of thyroid and breast cancer 

  Pinheiro, Maisa ; Drigo, Sandra Aparecida ; Tonhosolo, Renata; Andrade, Sonia C.S.; Marchi, Fabio Albuquerque; Jurisica, Igor; Kowalski, Luiz Paulo; Achatz, Maria Isabel; Rogatto, Silvia Regina (Oncotarget, 2017) [Artigo]

  Familial Papillary Thyroid Carcinoma (PTC) has been described as a hereditary predisposition cancer syndrome associated with mutations in candidate genes including HABP2. Two of 20 probands from families with history of ...

• An Unexpectedly High Rate of Thrombophilia Disorders in Patients with Superficial Vein Thrombosis of the Lower Extremities 

  Sobreira, Marcone Lima ; Rogatto, Silvia Regina ; dos Santos, Rodrigo Mattos ; Santos, Izolete Thomazini ; Ferrari, Iracema Carvalho ; Yoshida, Winston Bonetti (Annals of Vascular Surgery, 2017) [Artigo]

  Background Superficial vein thrombosis (SVT) is a common venous condition. Recent studies have shown that SVT is associated with high frequency of thromboembolic complications: from 22–37% for deep venous thrombosis and ...

• A case report of venous thrombosis after kidney transplantation – We can save the graft? Time is the success factor 

  Kawano, Paulo Roberto ; Yamamoto, Hamilto Akihissa ; Gerra, Rodrigo ; Garcia, Paula Dalsoglio ; Contti, Mariana Moraes ; Nga, Hong Si ; Takase, Henrique Mochida ; Bravin, Ariane Moyses ; de Andrade, Luis Gustavo Modelli (International Journal of Surgery Case Reports, 2017) [Artigo]

  Introduction Venous thrombosis is a serious surgical complication that frequently results in loss of kidney graft. Case presentation We report the case of a female patient recipient of a decease kidney transplant that in ...

• Integrated data analysis reveals potential drivers and pathways disrupted by DNA methylation in papillary thyroid carcinomas 

  Beltrami, Caroline Moraes; dos Reis, Mariana Bisarro ; Barros-Filho, Mateus Camargo; Marchi, Fabio Albuquerque; Kuasne, Hellen ; Pinto, Clóvis Antônio Lopes; Ambatipudi, Srikant; Herceg, Zdenko; Kowalski, Luiz Paulo; Rogatto, Silvia Regina (Clinical Epigenetics, 2017) [Artigo]

  Background: Papillary thyroid carcinoma (PTC) is a common endocrine neoplasm with a recent increase in incidence in many countries. Although PTC has been explored by gene expression and DNA methylation studies, the regulatory ...

• Integrative miRNA and mRNA analysis in penile carcinomas reveals markers and pathways with potential clinical impact 

  Kuasne, Hellen ; Barros-Filho, Mateus C.; Busso-Lopes, Ariane; Marchi, Fábio A.; Pinheiro, Maisa; Muñoz, Juan J.M.; Scapulatempo-Neto, Cristovam; Faria, Eliney F.; Guimarães, Gustavo C.; Lopes, Ademar et al. (Oncotarget, 2017) [Artigo]

  Penile carcinoma (PeCa) is an important public health issue in poor and developing countries, and has only recently been explored in terms of genetic and epigenetic studies. Integrative data analysis is a powerful method ...

• Germline large genomic alterations on 7q in patients with multiple primary cancers 

  Villacis, R. A.R.; Basso, T. R.; Canto, L. M.; Nóbrega, A. F.; Achatz, M. I.; Rogatto, S. R. (Scientific Reports, 2017) [Artigo]

  Patients with multiple primary cancers (MPCs) are suspected to have a hereditary cancer syndrome. However, only a small proportion may be explained by mutations in high-penetrance genes. We investigate two unrelated MPC ...

• Genomic profile in gestational and non-gestational choriocarcinomas 

  Mello, Julia Bette Homem de; Ramos Cirilo, Priscila Daniele; Michelin, Odair Carlito ; Custódio Domingues, Maria Aparecida ; Cunha Rudge, Marilza Vieira ; Rogatto, Silvia Regina ; Maestá, Izildinha (Placenta, 2017) [Artigo]

  Introduction Gestational (GC) (derived from the placenta) and non-gestational (NGC) choriocarcinomas are trophoblastic diseases originated from abnormal proliferation of trophoblastic cells. These rare tumors share similar ...

• Electrical stimulation with non-implanted electrodes for overactive bladder in adults 

  Stewart, Fiona; Gameiro, Luis F. ; El Dib, Regina ; Gameiro, Monica O. ; Kapoor, Anil; Amaro, Joao L. (Cochrane Database of Systematic Reviews, 2016) [Resenha]

  Background: Several options exist for managing overactive bladder (OAB), including electrical stimulation (ES) with non-implanted devices, conservative treatment and drugs. Electrical stimulation with non-implanted devices ...

• Genomic copy number variation associated with clinical outcome in canine cutaneous mast cell tumors 

  Jark, Paulo C ; Mundin, Deborah B.P.; de Carvalho, Marcio ; Ferioli, Raquel B. ; Anai, Letícia A ; Marchi, Fabio A.; Rogatto, Silvia R. ; Laufer-Amorim, Renee ; Tinucci-Costa, Mirela (Research in Veterinary Science, 2017) [Artigo]

  Mast cell tumors are the most common malignant cutaneous tumors in dogs. Although there are several prognostic factors involved, the clinical and biological behavior of this type of tumor varies greatly, making the best ...

• Effect of Hibiscus sabdariffa supplementation on renal function and lipidic profile in obese rats 

  Melchert, Alessandra ; Rosa, Andressa Canuto ; Genari, Vanessa ; Frontana, Marina Salvador Gonzales ; Da Costa Reis, Rodrigo Prandini ; Guimarães Okamoto, Priscylla Tatiana Chalfun ; Amaro, João Luiz ; Rahal, Sheila Canevese (Asian Journal of Animal and Veterinary Advances, 2016) [Artigo]

  Background and Objective: Obesity has emerged as a major public health problem and may be associated with chronic kidney diseases. Thus, this study aimed to evaluate the Hibiscus sabdariffa effects in the renal function ...

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