• Liposomal-based lidocaine formulation for the improvement of infiltrative buccal anaesthesia 

  de Almeida, Ana Cláudia Pedreira; Pinto, Luciana Matos Alves; Alves, Giuliana Piovesan; Ribeiro, Lígia Nunes de Morais; Santana, Maria Helena Andrade; Cereda, Cíntia Maria Saia; Fraceto, Leonardo Fernandes ; de Paula, Eneida (Journal of Liposome Research, 2018) [Artigo]

  This study describes the encapsulation of the local anaesthetic lidocaine (LDC) in large unilamellar liposomes (LUV) prepared in a scalable procedure, with hydrogenated soybean phosphatidylcholine, cholesterol and mannitol. ...

• Recent Developments and Challenges for Nanoscale Formulation of Botanical Pesticides for Use in Sustainable Agriculture 

  Luiz De Oliveira, Jhones ; Ramos Campos, Estefânia Vangelie ; Fraceto, Leonardo Fernandes (Journal of Agricultural and Food Chemistry, 2018) [Artigo]

  In recent years, the use of substances of natural origin, such as botanical pesticides, has emerged as a preferred alternative to the use of synthetic pesticides, the excessive use of which has raised a lot of concern over ...

• Nanoparticle mucoadhesive system as a new tool for fish immune system modulation 

  Charlie-Silva, Ives; de Melo, Nathalie Ferreira Silva; Gomes, Juliana M.M.; Fraceto, Leonardo Fernandes ; de Melo, Daniela Chemim; de Oliveira Silva, Juliana; de Barros, André Luis Branco; Corrêa, José Dias (Fish and Shellfish Immunology, 2018) [Artigo]

  Recently, chitosan-based nanoparticles with mucoadhesive properties emerged as a strategy for mucosal drug release. This study aimed to characterize the interaction of mucoadhesive system chitosancoated PLGA nanoparticles ...

• Biochar influence the production and release of exopolysaccharides on plant growth promoting bacteria 

  Bueno, Carolina C. ; Fraceto, Leonardo F. ; Rosa, André H. (Chemical Engineering Transactions, 2018) [Artigo]

  Biochar is known as a multifunctional carbonaceous material mainly used in agrosystems. Little information is available on possible antagonistic, toxicological and negative effects of biochar on soil microorganisms. This ...

• Trichoderma harzianum-based novel formulations: potential applications for management of Next-Gen agricultural challenges 

  Fraceto, Leonardo F ; Maruyama, Cintia R ; Guilger, Mariana; Mishra, Sandhya; Keswani, Chetan; Singh, Harikesh Bahadur; de Lima, Renata (Journal of Chemical Technology and Biotechnology, 2018) [Resenha]

  Fungi of the Trichoderma spp. genus, notably Trichoderma harzianum, are commonly used for biological management of deleterious seed- and soil-borne pathogens. The global biopesticides market is booming with a major share ...

• Publisher Correction: Chitosan nanoparticles functionalized with β-cyclodextrin: A promising carrier for botanical pesticides publisher 

  Campos, Estefânia V. R. ; Proença, Patrícia L. F. ; Oliveira, Jhones L. ; Melville, Cirano C. ; Della Vechia, Jaqueline F. ; De Andrade, Daniel J. ; Fraceto, Leonardo F. (Scientific Reports, 2018) [Errata]

  This Article contains an error in the order of the Figures. Figures 1, 2, 3, 4 and 5 were published as Figures 2, 3, 4, 5 and 1 respectively. The correct Figures 1, 2, 3, 4 and 5 appear below. The Figure legends are correct. ...

• Biosorption of macronutrients by Brazilian tropical peats 

  Melo, Camila Almeida ; de Oliveira, Lílian Karla ; Fraceto, Leonardo Fernandes ; Rosa, André Henrique (Communications in Soil Science and Plant Analysis, 2018) [Artigo]

  The objective of this work was to evaluate the adsorption of macronutrients calcium, potassium, magnesium, nitrogen, and phosphorus in two Brazilian tropical peat samples, investigating the effect of pH and determining the ...

• Carvacrol and linalool co-loaded in β-cyclodextrin-grafted chitosan nanoparticles as sustainable biopesticide aiming pest control 

  Campos, Estefânia V.R. ; Proença, Patrícia L.F. ; Oliveira, Jhones L. ; Pereira, Anderson E.S. ; De Morais Ribeiro, Lígia Nunes; Fernandes, Fabrício O. ; Gonçalves, Kelly C. ; Polanczyk, Ricardo A. ; Pasquoto-Stigliani, Tatiane; Lima, Renata et al. (Scientific Reports, 2018) [Artigo]

  Pesticides are the main tactics for pest control because they reduce the pest population very fast and their efficiency does not depend on abiotic factors. However, the indiscriminate use of these substances can speed up ...

• Geraniol Encapsulated in Chitosan/Gum Arabic Nanoparticles: A Promising System for Pest Management in Sustainable Agriculture 

  De Oliveira, Jhones Luiz ; Campos, Estefânia Vangelie Ramos; Pereira, Anderson E. S.; Nunes, Lucas E. S. ; Da Silva, Camila C. L. ; Pasquoto, Tatiane; Lima, Renata; Smaniotto, Giovani ; Polanczyk, Ricardo Antonio ; Fraceto, Leonardo F. (Journal of Agricultural and Food Chemistry, 2018) [Artigo]

  The nanoencapsulation of botanical compounds (such as geraniol) is an important strategy that can be used to increase the stability and efficiency of these substances in integrated pest management. In this study, chitosan/gum ...

• Bupivacaine in alginate and chitosan nanoparticles: An in vivo evaluation of efficacy, pharmacokinetics, and local toxicity 

  Cereda, Cíntia Maria Saia; Mecatti, Daniel Sebbe; Papini, Juliana Zampoli Boava; Bueno, Diego Valério; Franz-Montan, Michelle; Rocha, Thalita; Júnior, José Pedrazzoli; de Paula, Eneida; de Araújo, Daniele Ribeiro; Grillo, Renato et al. (Journal of Pain Research, 2018) [Artigo]

  Objective: This study reports a preclinical evaluation of an alginate/chitosan nanoparticle formulation containing NovaBupi®, a racemic bupivacaine (BVC) containing 25% dextrobupivacaine and 75% levobupivacaine. Methods: ...

• Use of botanical insecticides for sustainable agriculture: Future perspectives 

  Campos, Estefânia V.R. ; Proença, Patrícia L.F. ; Oliveira, Jhones L. ; Bakshi, Mansi; Abhilash, P. C.; Fraceto, Leonardo F. (Ecological Indicators, 2018) [Artigo]

  Recent decades have witnessed major growth in the use of agrochemicals worldwide, – for maximizing the food production for a rapidly growing human population. However, the indiscriminate use of these substances especially ...

• Zein nanoparticles and strategies to improve colloidal stability: A mini-review 

  Pascoli, Mônica ; de Lima, Renata; Fraceto, Leonardo F. (Frontiers in Chemistry, 2018) [Artigo]

  Zein, a protein extracted from maize, can be employed to easily produce nanoscale particles suitable for use as carrier systems. This review investigates the main methods for obtaining zein nanoparticles, as well as the ...

• Zein Nanoparticles as Eco-Friendly Carrier Systems for Botanical Repellents Aiming Sustainable Agriculture 

  Oliveira, Jhones L. De ; Campos, Estefânia V. R.; Pereira, Anderson E. S.; Pasquoto, Tatiane; Lima, Renata; Grillo, Renato ; Andrade, Daniel Junior De ; Santos, Fabiano Aparecido Dos ; Fraceto, Leonardo Fernandes (Journal of Agricultural and Food Chemistry, 2018) [Artigo]

  Botanical repellents represent one of the main ways of reducing the use of synthetic pesticides and the contamination of soil and hydric resources. However, the poor stability and rapid degradation of these compounds in ...

• Chitosan nanoparticles functionalized with β-cyclodextrin: A promising carrier for botanical pesticides 

  Campos, Estefânia V.R. ; Proença, Patrícia L.F. ; Oliveira, Jhones L. ; Melville, Cirano C. ; Vechia, Jaqueline F. Della ; De Andrade, Daniel J. ; Fraceto, Leonardo F. (Scientific Reports, 2018) [Artigo]

  Carvacrol and linalool are natural compounds extracted from plants and are known for their insecticidal and repellent activities, respectively. However, their low aqueous solubility, high photosensitivity, and high volatility ...

• Layer-by-layer films containing emodin or emodin encapsulated in liposomes for transdermal applications 

  Campos, Paula P. ; Fraceto, Leonardo Fernandes ; Ferreira, Marystela (Colloids and Surfaces B: Biointerfaces, 2018) [Artigo]

  Dermal drug release systems are an important area of research because they can be applied to the skin in a non-invasive procedure using a lower concentration of drugs. In this study, we have developed two types of ...

• Preface 

  Fraceto, Leonardo Fernandes ; de Araujo, Daniele Ribeiro (Microspheres: Technologies, Applications and Role in Drug Delivery Systems, 2014) [Editorial]

• Heightening awareness for graduate students of the potential impacts of nanomaterials on human health and the environment using a theoretical-practical approach 

  De Melo, Nathalie F.S.; Fraceto, Leonardo F. ; Grillo, Renato (Journal of Chemical Education, 2017) [Artigo]

  Rapid growth in nanoscience and nanotechnology in recent years has been accompanied by studies of the toxicity and potential impacts of nanomaterials on human health and the environment, but less has been done concerning ...

• Development of HA/Ag-NPs composite coating from green process for hip applications 

  Lozoya-Rodrfguez, Denisse A.; De Lima, Renata; Fraceto, Leonardo F. ; Pérez, Antonio Ledezma; Domfnguez, Mercedes Bazaldua; Batres, Roberto Gómez; Rojas, Armando Reyes; Carmona, Víctor Orozco (Molecules, 2017) [Artigo]

  In the present study, biological hydroxyapatite (HA) was obtained from bovine bones through a thermal process. A total of 0% and 1% of silver nanoparticles (Ag-NPs) synthesized from Opuntia ficus (nopal) were added to the ...

• Nanocapsules Containing Neem (Azadirachta Indica) Oil: Development, Characterization, and Toxicity Evaluation 

  Pasquoto-Stigliani, Tatiane; Campos, Estefânia V. R. ; Oliveira, Jhones L. ; Silva, Camila M. G.; Bilesky-José, Natalia; Guilger, Mariana; Troost, Johann; Oliveira, Halley C.; Stolf-Moreira, Renata; Fraceto, Leonardo F. et al. (Scientific Reports, 2017) [Artigo]

  In this study, we prepared, characterized, and performed toxicity analyses of poly(ϵ-caprolactone) nanocapsules loaded with neem oil. Three formulations were prepared by the emulsion/solvent evaporation method. The ...

• Evaluation of the effects of polymeric chitosan/tripolyphosphate and solid lipid nanoparticles on germination of Zea mays, Brassica rapa and Pisum sativum 

  Nakasato, Daniele Y. ; Pereira, Anderson E.S.; Oliveira, Jhones L. ; Oliveira, Halley C.; Fraceto, Leonardo F. (Ecotoxicology and Environmental Safety, 2017) [Artigo]

  Although the potential toxicity of many metallic and carbon nanoparticles to plants has been reported, few studies have evaluated the phytotoxic effects of polymeric and solid lipid nanoparticles. The present work described ...

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