Síntese e caracterização de composto de coordenação com ligante de produto natural
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Data
2017-03-08
Autores
Moralles, Vagner Antonio [UNESP]
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Editor
Universidade Estadual Paulista (Unesp)
Resumo
Alguns compostos orgânicos de origem natural apresentam grande interesse para aplicação médica devido suas atividades biológicas como antioxidante, antiviral, antimicrobiano, antitumoral, entre outras. Destes estes compostos, alguns se destacam por apresentarem a possibilidade de agir como ligante em compostos de coordenação. Para o desenvolvimento desse projeto de pesquisa, em especial, foram selecionados os ligantes 3,5,7,3’,4’- pentahidroxiflavona (quercetina), ácido 3,4,5-triidroxibenóico (ácido gálico), ácido (E)-3fenil- 2-propenóico (ácido cinâmico) e (E)-3-(4-hidroxifenil)-2-propanoico (ácido p-cumárico). Pretende-se, portanto, maximizar as atividades antioxidantes e antitumorais destes ligantes de origem natural, por meio da complexação em compostos de coordenação. Além disso, estudar as propriedades estruturais e ópticas dos complexos obtidos. O desenvolvimento dessa pesquisa permitiu encontrar uma relação entre a estrutura do ligante e suas propriedades ópticas quando excitados com radiação ultravioleta e raios X. Conseguiu-se também levantar algumas hipóteses sobre a potencialidade de utilização destes compostos de coordenação como filtros solares.
Some organic compounds of natural origin are of great interest for medical application due to their biological activities as antioxidant, antiviral, antimicrobial, antitumor, among others. Of these compounds, some are notable for their ability to act as a binder in coordination compounds. For the development of this research project, in particular, the binders were selected quercetin (2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one), Cinnamic acid (3-phenyl-2-propenoic acid) and p-coumaric acid ((E)-3-(4-hydroxyphenyl)-2-propenoic acid). It is therefore intended to maximize the antioxidant and antitumor activities of these naturally occurring binders by complexing into coordination compounds. In addition, to study the structural and optical properties of the complexes obtained. The development of this research allowed to find a relation between the structure of the binder and its optical properties when excited with ultraviolet radiation and X-rays. It was also possible to raise some hypotheses about the potential of using these coordination compounds as sunscreens.
Some organic compounds of natural origin are of great interest for medical application due to their biological activities as antioxidant, antiviral, antimicrobial, antitumor, among others. Of these compounds, some are notable for their ability to act as a binder in coordination compounds. For the development of this research project, in particular, the binders were selected quercetin (2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one), Cinnamic acid (3-phenyl-2-propenoic acid) and p-coumaric acid ((E)-3-(4-hydroxyphenyl)-2-propenoic acid). It is therefore intended to maximize the antioxidant and antitumor activities of these naturally occurring binders by complexing into coordination compounds. In addition, to study the structural and optical properties of the complexes obtained. The development of this research allowed to find a relation between the structure of the binder and its optical properties when excited with ultraviolet radiation and X-rays. It was also possible to raise some hypotheses about the potential of using these coordination compounds as sunscreens.
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Palavras-chave
Compostos de coordenação, Luminescência, Produtos naturais, Espectroscopia de raios X, Filtro solar, Coordination compounds, Luminescence, Natural products, X-ray spectroscopy, Sunscreen, Compuestos de coordinación, Luminiscencia, Productos naturales, Espectroscopia de rayos X, Protector solar