RSS 1.0Departamento de Fisiologia e Patologia
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Centrally acting adrenomedullin in the long-term potentiation of sympathetic vasoconstrictor activity induced by intermittent hypoxia in rats
Zoccal, Daniel B.
; Colombari, Debora S. A. ; Colombari, Eduardo ; Flor, Karine C. ; ; ; ; ; ; (Experimental Physiology, 2019) [Artigo]
New Findings: What is the central question of this study? Adrenomedullin in the rostral ventrolateral medulla (RVLM) increases sympathetic activity; given that adrenomedullin is released during hypoxia, what are the effects ... -
Cardiovascular and hidroelectrolytic changes in rats fed with high-fat diet
Sá, Jéssica Matheus; Barbosa, Rafaela Moreira ; Menani, José V. ; De Luca, Laurival Antônio ; Colombari, Eduardo ; Almeida Colombari, Débora Simões (Behavioural Brain Research, 2019) [Artigo]
Obesity activates the renin-angiotensin and sympathetic systems facilitating hypertension and changes in the hydroelectrolytic balance. In the present study, in rats fed with high-fat diet (HFD), we investigated daily water ... -
Interaction of central angiotensin II and aldosterone on sodium intake and blood pressure
Gasparini, S.; Melo, M. R. ; Nascimento, P. A. ; Andrade-Franzé, G. M.F. ; ; ; Menani, J. V. ; ; Colombari, E. (Brain Research, 2019) [Artigo]
Recent studies demonstrated an important natriorexigenic mechanism activated by aldosterone acting in the hindbrain. Studies have also shown that aldosterone effects are intensified by angiotensin II (ANG II) and vice-versa. ... -
Importance of AT1 and AT2 receptors in the nucleus of the solitary tract in cardiovascular responses induced by a high-fat diet
Speretta, Guilherme F.; Ruchaya, Prashant J. ; ; Melo, Mariana R. ; ; Menani, José V. ; ; Colombari, Eduardo ; Bassi, Mirian ; Colombari, Débora S. A. (Hypertension Research, 2019) [Artigo]
A high-fat diet (HFD) induces an increase in arterial pressure and a decrease in baroreflex function, which may be associated with increased expression of angiotensin type 1 receptor (AT1R) and pro-inflammatory cytokine ... -
Importance of the commissural nucleus of the solitary tract in renovascular hypertension
Melo, Mariana Rosso; Gasparini, Silvia ; Speretta, Guilherme F. ; ; ; Menani, Jose V. ; Zoccal, Daniel B. ; Colombari, Débora Simões Almeida ; Colombari, Eduardo (Hypertension Research, 2019) [Artigo]
The rodent renovascular hypertension model has been used to investigate the mechanisms promoting hypertension. The importance of the carotid body for renovascular hypertension has been demonstrated. As the commissural NTS ... -
Estradiol modulates the palatability of 0.3 M NaCl in female rats during sodium appetite
Pereira, E. D.; Dantas, R. M. ; Andrade-Franzé, G. M.F. ; De Luca, L. A. ; Menani, J. V. ; Andrade, C. A.F. (Appetite, 2019) [Artigo]
Excessive salt intake has been associated with the development or worsening of chronic diseases such as hypertension and spontaneously hypertensive rats (SHR) have a typical increased sodium preference. Estrogens reduce ... -
Interactions between terpinen-4-ol and nystatin on biofilm of Candida albicans and Candida tropicalis
Tonon, Caroline Coradi; Francisconi, Renata Serignoli ; Bordini, Ester Alves Ferreira ; Huacho, Patrícia Milagros Maquera ; ; Spolidorio, Denise Madalena Palomari (Brazilian Dental Journal, 2018) [Artigo]
The aim of this study was to evaluate the antifungal activity of Terpinen-4-ol associated with nystatin, on single and mixed species biofilms formed by Candida albicans and Candida tropicalis, as well as the effect of ... -
Endogenous hydrogen peroxide affects antidiuresis to cholinergic activation in the medial septal area
Sá, Jéssica Matheus; Barros, Milena Cassolatti ; Melo, Mariana Rosso ; Colombari, Eduardo ; Menani, José Vanderlei ; Colombari, Débora Simões Almeida (Neuroscience Letters, 2019) [Artigo]
Cholinergic activation of the medial septal area (MSA) with carbachol produces thirst, natriuresis and antidiuresis. Hydrogen peroxide (H 2 O 2 ) injected into the medial septal area (MSA) impairs behavioral and renal ... -
Central muscarinic and LPBN mechanisms on sodium intake
Anesio, Augusto; Barbosa, Silas Pereira ; De Luca, Laurival A. ; de Paula, Patrícia Maria ; Colombari, Débora S.A. ; Colombari, Eduardo ; Andrade, Carina A.F. ; Menani, José V. (Brain Research Bulletin, 2019) [Artigo]
Central cholinergic activation stimulates water intake, but also NaCl intake when the inhibitory mechanisms are blocked with injections of moxonidine (α2 adrenergic/imidazoline agonist) into the lateral parabrachial nucleus ... -
Carotid bodies contribute to sympathoexcitation induced by acute salt overload
da Silva, Elaine Fernanda; Bassi, Mirian ; Menani, José Vanderlei ; Colombari, Débora Simões Almeida ; Zoccal, Daniel Breseghello ; ; Colombari, Eduardo (Experimental Physiology, 2019) [Artigo]
New Findings: What is the central question of this study? Does carotid body input contribute to the hyperosmotic responses? What is the main finding and its importance? The response to NaCl overload is sympathorespiratory ... -
Antimicrobial effects of terpinen-4-ol against oral pathogens and its capacity for the modulation of gene expression
Bordini, Ester Alves Ferreira; Tonon, Caroline Coradi ; Francisconi, Renata Serignoli ; Magalhães, Fernando Augusto Cintra ; Huacho, Patrícia Milagros Maquera ; ; ; Spolidorio, Luis Carlos ; Spolidorio, Denise Palomari (Biofouling, 2018) [Artigo]
This study evaluated the antibacterial activity of terpinen-4-ol against Streptococcus mutans and Lactobacillus acidophilus and its influence on gbpA (S. mutans) and slpA (L. acidophilus) gene expression. As measured by ... -
Paracoccidioides brasiliensis 14-3-3 protein is important for virulence in a murine model
Marcos, Caroline Maria; de Oliveira, Haroldo Cesar ; Assato, Patricia Akemi ; de Andrade, Cleverton Roberto ; Fusco-Almeida, Ana Marisa ; Mendes-Giannini, Maria José Soares (Medical mycology, 2019) [Artigo]
The Paracoccidioides brasiliensis strain downregulated the expression of adhesin Pb14-3-3 (Pb14-3-3 aRNA) was evaluated in a murine model of paracoccidioidomycosis (PCM). Pb14-3-3 aRNA displays attenuated virulence and ... -
Increased whitening efficacy and reduced cytotoxicity are achieved by the chemical activation of a highly concentrated hydrogen peroxide bleaching gel
; Marcomini, Natália; Duque, Carla Caroline de Oliveira ; Bordini, Ester Alves Ferreira ; Zuta, Uxua Ortecho ; Basso, Fernanda Gonçalves ; Hebling, Josimeri ; Costa, Carlos Alberto de Souza (Journal of applied oral science : revista FOB, 2019) [Artigo]
OBJECTIVE: This study was designed for the chemical activation of a 35% hydrogen peroxide (H2O2) bleaching gel to increase its whitening effectiveness and reduce its toxicity. METHODOLOGY: First, the bleaching gel - ... -
Effects of an Er,Cr:YSGG Laser on Bone Regeneration in Critical-Sized Calvarial Defects of Rats Exposed to Inhalation of Cigarette Smoke
; Scardueli, Cássio Rocha; ; Cerri, Paulo Sérgio ; Marcantonio Junior, Elcio ; Marcantonio, Rosemary Adriana Chiérici (Photobiomodulation, Photomedicine, and Laser Surgery, 2019) [Artigo]
Objective: To evaluate the effect of the Er,Cr:YSGG laser on healing of critical-sized calvarial defects (CSDs) in rats submitted to inhalation of cigarette smoke. Background: Smoking has been implicated with the delay in ... -
Human pulp response to conventional and resin-modified glass ionomer cements applied in very deep cavities
; ; ; Bordini, Ester Alves Ferreira; de Souza Costa, Carlos Alberto ; Hebling, Josimeri (Clinical Oral Investigations, 2019) [Artigo]
Objectives: This study assessed the human pulp response after adhesive restoration of cavities by indirect pulp capping with a conventional or a resin-modified glass ionomer cement. Materials and methods: Deep cavities ... -
Influence of zirconia-coated bioactive glass on gingival fibroblast behavior
Barros, Suelen Aline de Lima; ; Leite, Maria Luísa ; Basso, Fernanda Gonçalves ; Costa, Carlos Alberto de Souza ; Adabo, Gelson Luís (Brazilian Dental Journal, 2019) [Artigo]
The objective of this study was the development of a bioactive glass coating on zirconia (Zr) to modulate the gingival fibroblast phenotype. For this purpose, Biosilicate® (BS) particles in a water/isopropyl alcohol (1:1) ... -
Antimicrobial photodynamic therapy reduces adhesion capacity and biofilm formation of Candida albicans from induced oral candidiasis in mice
Cabrini Carmello, Juliana; Alves, Fernanda ; Basso, Fernanda G. ; de Souza Costa, Carlos Alberto ; ; Lucas Primo, Fernando ; Mima, Ewerton Garcia de Oliveira ; Pavarina, Ana Cláudia (Photodiagnosis and Photodynamic Therapy, 2019) [Artigo]
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Effects of enzymatic activation of bleaching gels on hydrogen peroxide degradation rates, bleaching effectiveness, and cytotoxicity
Zuta, Uxua Ortecho; De Oliveira Duque, Carla Caroline ; De Alencar E Silva Leite, Maria Luísa ; Bordini, Ester Alves Ferreira ; Basso, Fernanda Gonçalves ; Hebling, Josimeri ; De Souza Costa, Carlos Alberto ; (Operative Dentistry, 2019) [Artigo]
Objectives: The aim of this study was to evaluate the effect of horseradish peroxidase (HRP) on the release of free radicals, bleaching effectiveness, and indirect cytotoxicity of a 35% hydrogen peroxide (HP) bleaching ... -
Cardiovascular outcomes related to social defeat stress: New insights from resilient and susceptible rats
Morais-Silva, Gessynger; Costa-Ferreira, Willian ; Gomes-de-Souza, Lucas ; Pavan, Jacqueline C. ; Crestani, Carlos C. ; Marin, Marcelo T. (Neurobiology of Stress, 2019) [Artigo]
Stress exposure is an important risk factor for psychiatric and cardiovascular disorders. Two phenotypes related to coping with stress can be observed in rodents that experience chronic social defeat stress (SDS): susceptible, ... -
Synergistic potential of 1α,25-dihydroxyvitamin D3 and calcium–aluminate–chitosan scaffolds with dental pulp cells
Bordini, Ester Alves Ferreira; Cassiano, Fernanda Balestrero ; ; Usberti, Felipe Rochelle ; Anovazzi, Giovana ; ; Pansani, Taísa Nogueira ; Leite, Maria Luísa ; Hebling, Josimeri ; de Souza Costa, Carlos Alberto et al. (Clinical Oral Investigations, 2019) [Artigo]
Objectives: This study aimed to develop a porous chitosan–calcium–aluminate scaffold (CH-AlCa) in combination with a bioactive dosage of 1α,25-dihydroxyvitamin D3 (1α,25VD), to be used as a bioactive substrate capable to ...