White adipose tissue IFN-γ expression and signalling along the progression of rodent cancer cachexia
Carregando...
Data
2017-01-01
Autores
Yamashita, Alex Shimura
das Neves, Rodrigo Xavier
Rosa-Neto, José Cesar
Lira, Fábio dos Santos [UNESP]
Batista, Miguel Luís
Alcantara, Paulo Sérgio
Otoch, José Pinhata
Seelaender, Marília
Título da Revista
ISSN da Revista
Título de Volume
Editor
Resumo
Cachexia is associated with increased morbidity and mortality in cancer. The White adipose tissue (WAT) synthesizes and releases several pro-inflammatory cytokines that play a role in cancer cachexia-related systemic inflammation. IFN-γ is a pleiotropic cytokine that regulates several immune and metabolic functions. To assess whether IFN-γ signalling in different WAT pads is modified along cancer-cachexia progression, we evaluated IFN-γ receptors expression (IFNGR1 and IFNGR2) and IFN-γ protein expression in a rodent model of cachexia (7, 10, and 14 days after tumour implantation). IFN-γ protein expression was heterogeneously modulated in WAT, with increases in the mesenteric pad and decreased levels in the retroperitoneal depot along cachexia progression. Ifngr1 was up-regulated 7 days after tumour cell injection in mesenteric and epididymal WAT, but the retroperitoneal depot showed reduced Ifngr1 gene expression. Ifngr2 gene expression was increased 7 and 14 days after tumour inoculation in mesenteric WAT. The results provide evidence that changes in IFN-γ expression and signalling may be perceived at stages preceding refractory cachexia, and therefore, might be employed as a means to assess the early stage of the syndrome.
Descrição
Palavras-chave
Cancer-cachexia, Interferon-γ signalling, White adipose tissue
Como citar
Cytokine, v. 89, p. 122-126.