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dc.contributor.authorGarcia, Leandro E. [UNESP]
dc.contributor.authorJunior, Erivelto C. A. [UNESP]
dc.contributor.authorBragato, Jaqueline P. [UNESP]
dc.contributor.authorMelo, Larissa M. [UNESP]
dc.contributor.authorLima, Valéria F. M. [UNESP]
dc.contributor.authorPeiró, Juliana R. [UNESP]
dc.contributor.authorArnold, Daniel R. [UNESP]
dc.contributor.authorMarinho, Márcia [UNESP]
dc.contributor.authorLopes, Flavia L. [UNESP]
dc.date.accessioned2018-12-11T17:38:16Z
dc.date.available2018-12-11T17:38:16Z
dc.date.issued2018-08-21
dc.identifierhttp://dx.doi.org/10.1038/sdata.2018.171
dc.identifier.citationScientific Data, v. 5.
dc.identifier.issn2052-4463
dc.identifier.urihttp://hdl.handle.net/11449/180128
dc.description.abstractMicroRNAs play an important role in the regulation of immune responses. The influence of epigenetic mechanisms, particularly RNA-mediated post-transcriptional regulation of host immune responses has been proven vital following infections by different pathogens, and bacteria can modulated host miRNAs. Global miRNA expression analysis from macrophages infected in vitro with different strains of Leptospira spp was performed using miRNA 4.1 microarray strips. Leptospirosis is a bacterial zoonosis of global importance, responsible for significant morbidity and mortality worldwide. Despite considerable advances, much is yet to be discovered about disease pathogenicity, particularly in regards to host-pathogen interactions. We present here a high-quality dataset examining the microtranscriptome of murine macrophages J774A.1 following 8h of infection with virulent, attenuated and saprophyte strains of Leptospira. Metadata files were submitted to the Gene Expression Omnibus (GEO) repository.en
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.language.isoeng
dc.relation.ispartofScientific Data
dc.sourceScopus
dc.titleData descriptor: MicroRNA profile datasets of murine macrophages infected with different strains of leptospira sppen
dc.typeArtigo
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.description.affiliationDepartment of Support Production and Animal Health São Paulo State University (Unesp) School of Veterinary Medicine
dc.description.affiliationDepartment of Clinics Surgery and Animal Reproduction São Paulo State University (Unesp) School of Veterinary Medicine
dc.description.affiliationUnespDepartment of Support Production and Animal Health São Paulo State University (Unesp) School of Veterinary Medicine
dc.description.affiliationUnespDepartment of Clinics Surgery and Animal Reproduction São Paulo State University (Unesp) School of Veterinary Medicine
dc.identifier.doi10.1038/sdata.2018.171
dc.rights.accessRightsAcesso aberto
dc.description.sponsorshipIdFAPESP: 2015/14229-5
dc.identifier.scopus2-s2.0-85052141821
dc.identifier.file2-s2.0-85052141821.pdf
dc.identifier.lattes5071093931017493
unesp.author.lattes5071093931017493
dc.relation.ispartofsjr3,026
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