RSS 1.0Departamento de Microbiologia e Imunologia
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Brazilian red propolis exerts a cytotoxic action against prostate cancer cells and upregulates human monocyte functions
Santiago, Karina Basso
; Rodrigues, João Carlos Zamae ; de Oliveira Cardoso, Eliza ; Conte, Fernanda Lopes ; Tasca, Karen Ingrid ; ; ; ; Sforcin, José Maurício (Phytotherapy Research, 2022) [Artigo]
Different propolis samples can be obtained in Brazil, such as green, brown and red. Studies related to Brazilian red propolis (BRP) have increased in the last few years, so the aim of this study was to investigate its ... -
New insights on Leptospira sp. infection in ewes maintained in field semiarid conditions
; ; ; Junior, Joao Pessoa Araujo; Malossi, Camila Dantas ; Ullmann, Leila Sabrina ; ; ; ; (Acta Tropica, 2022) [Artigo]
Leptospirosis is poorly studied in small ruminants raised in field semiarid conditions. In this study we compared serological, bacteriological and molecular diagnostic methods in ewes maintained in field Brazilian semiarid ... -
Clinical and Eco-Epidemiological Aspects of a Novel Hyperendemic Area of Paracoccidioidomycosis in the Tocantins-Araguaia Basin (Northern Brazil), Caused by Paracoccidioides sp.
; Yamauchi, Danielle H.; ; ; Garces, Hans G. ; ; ; ; Bagagli, Eduardo ; et al. (Journal of Fungi, 2022) [Artigo]
Paracoccidioidomycosis (PCM) is the most prevalent systemic mycosis in Brazil. The disease is caused by dimorphic fungi nested within the Paracoccidioides genus. We described 106 PCM cases (47.1 cases/year) at the Tropical ... -
Inflammasomes in placental explants of women with preeclampsia cultured with monosodium urate may be modulated by vitamin D
Nunes, Priscila Rezeck; Romao-Veiga, Mariana ; Ribeiro, Vanessa Rocha ; de Oliveira, Larissa Ragozo Cardoso ; de Carvalho Depra, Igor ; de Oliveira, Leandro Gustavo ; Peracoli, Jose Carlos ; Peracoli, Maria Terezinha Serrao (Hypertension in Pregnancy, 2022) [Artigo]
Objectives: Preeclampsia (PE) is an important syndrome of gestation characterized by placental and systemic inflammation. High plasma concentration of uric acid are frequently associated with inflammation and endothelial ... -
Modular Label-Free Electrochemical Biosensor Loading Nature-Inspired Peptide toward the Widespread Use of COVID-19 Antibody Tests
(ACS Nano, 2022) [Artigo]Limitations of the recognition elements in terms of synthesis, cost, availability, and stability have impaired the translation of biosensors into practical use. Inspired by nature to mimic the molecular recognition of the ... -
Detection of Listeria innocua in the dairy processing chain: resistance to antibiotics and essential oils
; ; ; ; ; Rall, Vera Lucia Mores; ; (Food Science and Technology (Brazil), 2022) [Artigo]
Listeria monocytogenes is a food pathogen responsible for many foodborne disease outbreaks. Listeria innocua is similar to L. monocytogenes, could be considered biologically similar to L. monocytogenes and could be used ... -
Cryptococcus neoformans Prp8 Intein: An In Vivo Target-Based Drug Screening System in Saccharomyces cerevisiae to Identify Protein Splicing Inhibitors and Explore Its Dynamics
; ; ; ; Santoni, Mariana Marchi; ; Zanelli, Cleslei Fernando ; ; Bagagli, Eduardo ; (Journal of Fungi, 2022) [Artigo]
Inteins are genetic mobile elements that are inserted within protein-coding genes, which are usually housekeeping genes. They are transcribed and translated along with the host gene, then catalyze their own splicing out ... -
Prevalence of bovine mastitis-related pathogens, identified by mass spectrometry in flies (Insecta, Diptera) captured in the milking environment
Bertolini, A. B.; ; ; de Souza Ribeiro Mioni, M. ; de Gouvea, F. L.R. ; ; Langoni, H. ; de Figueiredo Pantoja, J. C. ; Rall, V. M. ; Guimarães, F. F. et al. (Letters in Applied Microbiology, 2022) [Resenha]
Diptera (Insecta) are able to transmit approximately 200 pathogenic microorganisms to humans and animals, causing more than 65 diseases, including bovine mastitis, which constitutes a major cause of economic losses in the ... -
Presence of Staphylococcus aureus and staphylococcal enterotoxin A Production and Inactivation in Brazilian Cheese Bread
; ; Teixeira, Nathalia Bibiana; de Lourdes Ribeiro de Souza da Cunha, Maria ; (Brazilian Archives of Biology and Technology, 2022) [Artigo]
Ingesting food contaminated by pathogens and/or their toxins can cause foodborne illness. In this sense, this study investigated the occurrence of enterotoxigenic S. aureus in frozen cheese bread dough and assessed the ... -
Persistence of Staphylococcus spp. in milk from cows undergoing homeopathy to control subclinical mastitis
Ferreira, Elka Machado; Romero, Letícia Castilho ; Cunha, Maria de Lourdes Ribeiro de Souza da ; ; ; ; (BMC Veterinary Research, 2022) [Artigo]
Background: Mastitis is one of the major diseases in dairy cattle, as it causes great economic losses to producers due to the reduction of milk production and changes in the quality of the product. The disease is mainly ... -
Salmonella spp. in low water activity food: Occurrence, survival mechanisms, and thermoresistance
; Rall, Vera Lúcia Mores; Dantas, Stéfani Thais Alves ; ; (Journal of Food Science, 2022) [Artigo]
The occurrence of disease outbreaks involving low-water-activity (aw) foods has gained increased prominence due in part to the fact that reducing free water in these foods is normally a measure that controls the growth and ... -
An overview about apitherapy and its clinical applications
Weis, Wilson Antonio; Ripari, Nicolas ; Conte, Fernanda Lopes ; Honorio, Mariana da Silva ; Sartori, Arthur Alves ; Matucci, Ramon Hage ; Sforcin, José Maurício (Phytomedicine Plus, 2022) [Resenha]
Background: Humanity has benefited from bee products over the centuries for treating and preventing various illnesses, and apitherapy has been employed in several countries as a complementary medicine. This review aimed ... -
Exploring the antioxidant, anti-inflammatory and antiallergic potential of Brazilian propolis in monocytes
Conte, Fernanda Lopes; ; ; ; ; ; ; ; ; Sforcin, José Maurício et al. (Phytomedicine Plus, 2022) [Artigo]
Background: Propolis is a bee product used since ancient times due to its diverse biological applications. We aimed to investigate the antioxidant and anti-inflammatory action of Brazilian propolis in THP-1 cells stimulated ... -
Is there a window of opportunity for the therapeutic use of vitamin D in multiple sclerosis?
Zorzella-Pezavento, Sofia Fernanda Gonçalves; Mimura, Luiza Ayumi Nishiyama ; Denadai, Marina Bonifácio ; De Souza, William Danilo Fernandes ; Fraga-Silva, Thais Fernanda De Campos ; Sartori, Alexandrina (Neural Regeneration Research, 2022) [Resenha]
Multiple sclerosis is an autoimmune treatable but not curable disease. There are a multiplicity of medications for multiple sclerosis therapy, including a class entitled disease-modifying drugs that are mainly indicated ... -
Molecular detection of Leishmania infantum in donkeys and mules under semiarid conditions in Brazil
; ; Júnior, João Pessoa Araújo; Malossi, Camila Dantas ; Ullmann, Leila Sabrina ; ; ; (Revista Brasileira de Parasitologia Veterinaria, 2021) [Artigo]
Visceral leishmaniasis is a parasitic zoonosis that mainly affects poorest and most vulnerable populations, and domestic dogs are considered to be the main source of infection to the vector and therefore humans. However, ... -
Vitamin D decreases cell death and inflammation in human umbilical vein endothelial cells and placental explants from pregnant women with preeclampsia cultured with TNF-α
Nunes, Priscila Rezeck; Romao-Veiga, Mariana ; Ribeiro, Vanessa Rocha ; de Oliveira, Larissa Ragozo Cardoso ; Zupelli, Thiago Gameiro ; Abbade, Joelcio Francisco ; Peracoli, Jose Carlos ; Peracoli, Maria Terezinha Serrao (Immunological Investigations, 2021) [Artigo]
This study evaluated the impact of vitamin D on Human Umbilical Vein Endothelial Cells (HUVEC) and inflammation in placental explants from women with preeclampsia (PE). HUVEC and explants from 10 late-onset PE (LOPE), 10 ... -
Brazilian green propolis: A novel tool to improve the cytotoxic and immunomodulatory action of docetaxel on MCF-7 breast cancer cells and on women monocyte
de Oliveira Cardoso, Eliza; Santiago, Karina Basso ; Conti, Bruno José ; Conte, Fernanda Lopes ; Tasca, Karen Ingrid ; ; de Assis Golim, Marjorie ; Rainho, Cláudia Aparecida ; ; Sforcin, José Maurício (Phytotherapy Research, 2022) [Artigo]
Docetaxel (DTX) is used against breast cancer despite its side effects such as toxicity and immunosuppression. Here we investigated the cytotoxic and immunomodulatory effects of the ethanol solution extract of propolis ... -
Association between Adverse Maternal Clinical Outcomes and Imbalance of Cytokines and Angiogenic Factors in Preterm Preeclampsia
Nunes, Priscila Rezeck; Romao-Veiga, Mariana ; Borges, Vera Therezinha Medeiros ; Matias, Mariana Leticia ; Ribeiro, Vanessa Rocha ; Costa, Roberto Antonio Araujo ; Peracoli, Maria Terezinha Serrao ; Peracoli, Jose Carlos (Revista Brasileira de Ginecologia e Obstetricia, 2021) [Artigo]
Objective Preeclampsia (PE) is a pregnancy-specific syndrome characterized by abnormal levels of cytokines and angiogenic factors, playing a role in the disease development. The present study evaluated whether immunological ... -
Physical, functional and biochemical features of Nanoskin® bacterial cellulose scaffold as a potential carrier for cell transference
Viveiros, Magda Massae Hata; Rainho, Cláudia Aparecida ; Ramirez, Jofer Andree Zamame ; Kaneno, Ramon ; Silva, Márcia Guimarães ; Ximenes, Valdecir Farias ; ; ; ; Schellini, Silvana Artioli (Materials Letters, 2022) [Artigo]
We evaluated the feasibility of Nanoskin®, a bacterial cellulose (BC) nanofiber membrane, as a potential scaffold for cell transference therapy. Nanoskin® does not induce lymphocyte proliferation, but it does not kill ... -
Two Novel Mutations Associated with Polymyxin-B Resistance in a Pandemic Lineage of Uropathogenic Escherichia coli of the Sequence Type 69
; Hernandes, Rodrigo Tavanelli; ; ; ; ; ; (Chemotherapy, 2021) [Artigo]
Background: Uropathogenic Escherichia coli (UPEC) are frequent pathogens worldwide, impacting on the morbidity and economic costs associated with antimicrobial treatment. Objectives: We report two novel mutations associated ...