• Can the antral follicular count modulate the gene expression of bovine oviducts in Aberdeen angus and nelore heifers? 

  Fontes, Patricia Kubo ; Ereno, Ronaldo Luis ; Peixoto, André Rebello ; Carvalho, Robson Francisco ; Scarano, Wellerson Rodrigo ; Trinca, Luzia Aparecida ; Barros, Ciro Moraes ; de Souza Castilho, Anthony César (PLoS ONE, 2018) [Artigo]

  The number of visible ovarian antral follicles (antral follicle count—AFC) is repeatable in bovine individuals, but highly variable between animals, and with differences between Bos taurus and Bos indicus breeds. Several ...

• Developmental programming of the female neuroendocrine system by steroids 

  Abruzzese, Giselle Adriana; Crisosto, Nicolás; De Grava Kempinas, Wilma ; Sotomayor-Zárate, Ramón (Journal of Neuroendocrinology, 2018) [Artigo]

  Developmental programming refers to processes that occur during early life that may have long-term consequences, modulating adult health and disease. Complex diseases, such as diabetes, cancer and cardiovascular disease, ...

• Pharmacological characterization of cnidarian extracts from the Caribbean Sea: Evaluation of anti-snake venom and antitumor properties 

  Oliveira, Cláudia S.; Caldeira, Cleópatra A.S.; Diniz-Sousa, Rafaela; Romero, Dolores L.; Marcussi, Silvana; Moura, Laura A.; Fuly, André L.; de Carvalho, Cicília ; Cavalcante, Walter L.G. ; Gallacci, Márcia et al. (Journal of Venomous Animals and Toxins Including Tropical Diseases, 2018) [Artigo]

  Background: Cnidarians produce toxins, which are composed of different polypeptides that induce pharmacological effects of biotechnological interest, such as antitumor, antiophidic and anti-clotting activities. This study ...

• Structural basis of phospholipase A2-like myotoxin inhibition by chicoric acid, a novel potent inhibitor of ophidian toxins 

  Cardoso, Fábio F. ; Borges, Rafael J. ; Dreyer, Thiago R. ; Salvador, Guilherme H.M. ; Cavalcante, Walter L.G. ; Pai, Maeli Dal ; Gallacci, Márcia ; Fontes, Marcos R.M. (Biochimica et Biophysica Acta - General Subjects, 2018) [Artigo]

  Background: Specific compounds found in vegetal species have been demonstrated to be efficient inhibitors of snake toxins, such as phospholipase A2-like (PLA2-like) proteins. These particular proteins, present in several ...

• Reproductive outcomes in rat female offspring from male rats co-exposed to rosuvastatin and ascorbic acid during pre-puberty 

  Leite, Gabriel Adan Araujo ; Figueiredo, Thamiris Moreira ; Pacheco, Tainá Louise ; Guerra, Marina Trevizan ; Anselmo-Franci, Janete Aparecida; Kempinas, Wilma De Grava (Journal of Toxicology and Environmental Health - Part A: Current Issues, 2018) [Artigo]

  Dyslipidemias are occurring earlier in different countries due to the increase of obesity, bad eating habits, and sedentary lifestyle. Rosuvastatin reduces serum cholesterol; however, several studies associated statin ...

• Impact of intrauterine exposure to betamethasone on the testes and epididymides of prepubertal rats 

  de Barros, Jorge Willian Franco ; Borges, Cibele dos Santos ; Missassi, Gabriela ; Pacheco, Tainá Louise ; De Grava Kempinas, Wilma (Chemico-Biological Interactions, 2018) [Artigo]

  Therapy with betamethasone, a synthetic glucocorticoid, is used in cases of preterm birth risk, in order to promote fetal lung maturation, and decrease neonatal mortality and morbidity. However, late reproductive disorders ...

• Protective effect of resveratrol on urogenital sinus and prostate development in rats exposed in utero to TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) 

  Silveira, Lívia Teresa Ribeiro ; de Mello Santos, Talita; Camora, Lucas Fredini ; Pinho, Cristiane Figueiredo ; Anselmo-Franci, Janete A.; Domeniconi, Raquel Fantin; Justulin, Luis Antonio ; Barbisan, Luis Fernando ; Scarano, Wellerson Rodrigo (Reproductive Toxicology, 2018) [Artigo]

  This study evaluated the protective effects of resveratrol on the prostate development of rats exposed to TCDD. Pregnant rats received TCDD (1 μg/kg) at GD15 and/or RES (20 mg/kg/day) from GD10 to PND21. Newborn and adult ...

• Bisphenol a and mesenchymal stem cells: Recent insights 

  Nunes, Helga Caputo ; Scarano, Wellerson Rodrigo ; Deffune, Elenice ; Felisbino, Sérgio Luis ; Porreca, Immacolata; Delella, Flávia Karina (Life Sciences, 2018) [Resenha]

  Mesenchymal stem cells (MSCs) are found in all adult mesenchymal tissues. They play a role in the maintenance of tissue homeostasis and repair by allowing renewal of the cellular stock. MSCs can be isolated from both human ...

• Landscape of transposable elements focusing on the B chromosome of the cichlid fish astatotilapia latifasciata 

  Coan, Rafael L. B. ; Martins, Cesar (Genes, 2018) [Artigo]

  B chromosomes (Bs) are supernumerary elements found in many taxonomic groups. Most B chromosomes are rich in heterochromatin and composed of abundant repetitive sequences, especially transposable elements (TEs). B origin ...

• Fractal dimension analysis reveals skeletal muscle disorganization in mdx mice 

  Cury, Sarah Santiloni ; Freire, Paula Paccielli ; Martinucci, Bruno ; dos Santos, Veridiana Carvalho ; de Oliveira, Grasieli ; Ferretti, Renato ; Dal-Pai-Silva, Maeli ; Pacagnelli, Francis Lopes; Delella, Flávia Karina ; Carvalho, Robson Francisco (Biochemical and Biophysical Research Communications, 2018) [Artigo]

  Duchenne Muscular Dystrophy (DMD) is characterized by muscle extracellular matrix disorganization due to the increased collagen deposition leading to fibrosis that significantly exacerbates disease progression. Fractal ...

• Cytogenetics characterization of Crenuchus spilurus (Günther, 1863): a remarkable low diploid value within family Crenuchidae (Characiformes) 

  Pazian, Marlon F. ; Oliveira, Claudio ; Foresti, Fausto (Biologia (Poland), 2018) [Artigo]

  Conventional and molecular cytogenetic analyses were performed in specimens of the Neotropical Crenuchus spilurus freshwater fish species from a single location (Caeté River, Brazil). All specimens presented diploid values ...

• The Epididymis as a Target for Toxicants 

  De Grava Kempinas, W. ; Klinefelter, G. R. (Comprehensive Toxicology: Third Edition, 2017) [Capítulo de livro]

  The epididymis is the organ in which sperm mature by developing the capacity for progressive motion and fertilizing ability. There is evidence that sperm quality in humans and other animals has diminished, in parallel with ...

• Lower sperm quality and testicular and epididymal structural impairment in adult rats exposed to rosuvastatin during prepuberty 

  Leite, Gabriel Adan Araújo ; Sanabria, Marciana ; Cavariani, Marilia Martins ; Anselmo-Franci, Janete Aparecida; Pinheiro, Patrícia Fernanda Felipe ; Domeniconi, Raquel Fantin ; Kempinas, Wilma De Grava (Journal of Applied Toxicology, 2018) [Artigo]

  The increase of obesity, bad eating habits and the lack of physical exercises are highly related to dyslipidemias. Rosuvastatin is a lipid-lowering drug and has been indicated to prevent cardiovascular diseases and to treat ...

• DNA barcoding techniques used to identify the shared ichthyofauna between the Pantanal floodplain and Upper Parana River 

  da Costa-Silva, Guilherme J. ; Yuldi Ashikaga, Fernando ; Kioko Shimabukuro Dias, Cristiane ; Garcia Pereira, Luiz Henrique; Foresti, Fausto ; Oliveira, Claudio (Mitochondrial DNA Part A: DNA Mapping, Sequencing, and Analysis, 2018) [Artigo]

  The biological invasion process is widely debated topic, as the population depletion of some species and the extinction of others are related to this process. To accelerate the identification of species and to detect ...

• Combinatorial Effect of Abiraterone Acetate and NVP-BEZ235 on Prostate Tumor Progression in Rats 

  Gonçalves, Bianca Facchim ; de Campos, Silvana Gisele Pegorin ; Fávaro, Wagner José; Brandt, Joyce Zalotti ; Pinho, Cristiane Figueiredo ; Justulin, Luis Antônio ; Taboga, Sebastião Roberto ; Scarano, Wellerson Rodrigo (Hormones and Cancer, 2018) [Artigo]

  Use of drug combinations that target different pathways involved in the development and progression of prostate cancer (PCa) has emerged as an alternative to overcome the resistance caused by drug monotherapies. The ...

• Uncovering the evolutionary history of neo-XY sex chromosomes in the grasshopper Ronderosia bergii (Orthoptera, Melanoplinae) through satellite DNA analysis 

  Palacios-Gimenez, Octavio M. ; Milani, Diogo ; Lemos, Bernardo; Castillo, Elio R.; Martí, Dardo A.; Ramos, Erica ; Martins, Cesar ; Cabral-De-Mello, Diogo C. (BMC Evolutionary Biology, 2018) [Artigo]

  Background: Neo-sex chromosome systems arose independently multiple times in evolution, presenting the remarkable characteristic of repetitive DNAs accumulation. Among grasshoppers, occurrence of neo-XY was repeatedly ...

• Hyperglycemic condition during puberty increases collagen fibers deposition in the prostatic stroma and reduces MMP-2 activity 

  Santos, Sérgio Alexandre Alcantara dos ; Porto Amorim, Elaine Manoela; Ribeiro, Larissa Mayume ; Rinaldi, Jaqueline Carvalho; Delella, Flávia Karina; Justulin, Luis Antonio ; Felisbino, Sérgio Luis (Biochemical and Biophysical Research Communications, 2017) [Artigo]

  Puberty is an important period for the growth and maturation of the male reproductive system, and is also a critical window for endocrine or environmental interference. The physiological levels of circulating insulin and ...

• Wear monitoring of single-point dresser in dry dressing operation based on neural models 

  Junior, Pedro O. ; Souza, Rubens V. ; Ferreira, Fábio I. ; Martins, Cesar H. ; Aguiar, Paulo R. ; Bianchi, Eduardo C. (Proceedings of the IASTED International Conference on Modelling, Identification and Control, 2017) [Trabalho apresentado em evento]

  The monitoring of different machining processes has been studied for years, however many processes still do not have a final solution for their controls. The dressing, as it is of great importance in the finishing of ...

• Arsenic trioxide exposure impairs testicular morphology in adult male mice and consequent fetus viability 

  da Silva, Raquel Frenedoso; Borges, Cibele dos Santos ; Lamas, Celina de Almeida; Cagnon, Valéria Helena Alves; Kempinas, Wilma de Grava (Journal of Toxicology and Environmental Health - Part A: Current Issues, 2017) [Artigo]

  The acute promyelocytic leukemia (APL) is a rare disease, affecting 0.1/100,000 individuals globally. Despite significant advances in APL therapy, some patients still experience relapsed disease. Currently, arsenic trioxide ...

• Bisphenol A Exposure Impairs Epididymal Development during the Peripubertal Period of Rats: Inflammatory Profile and Tissue Changes 

  Ogo, Fernanda Mithie; de Lion Siervo, Glaucia Eloisa Munhoz; Staurengo-Ferrari, Larissa; de Oliveira Mendes, Leonardo ; Luchetta, Nicla Renata; Vieira, Henrique Rodrigues; Fattori, Victor; Verri, Waldiceu Aparecido; Scarano, Wellerson Rodrigo ; Fernandes, Glaura Scantamburlo Alves (Basic and Clinical Pharmacology and Toxicology, 2018) [Artigo]

  Bisphenol A (BPA) is a synthetic non-steroidal oestrogen used in the production of plastics. BPA can cause alterations in the endocrine system of human beings and animals at varied stages of development. During puberty, ...

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