RSS 1.0Departamento de Morfologia
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Cylindrospermopsin Disrupts Estrous Cycle and Increases Spermatogenesis in Mice
; ; ; Nóbrega, Rafael Henrique
; ; (Reproductive Sciences, 2022) [Artigo]
Cylindrospermopsin (CYN) is a water-soluble cyanotoxin that has been linked to several cases of poisoning in the world. In vitro studies have shown that CYN acts as an endocrine disruptor by inhibiting progesterone synthesis ... -
Toxicological analysis and efficacy of 2-phenylchromone on mycobacteria viability and inflammatory response induced by Mycobacterium bovis
; ; ; ; ; ; ; Arena, Arielle Cristina; ; et al. (Phytomedicine Plus, 2021) [Artigo]
Background: Studies have reported that compounds similar to flavone present antimicrobial and anti-inflammatory properties; however these effects are poorly described in the context of mycobacterium infection. Purpose: ... -
Beta-caryophyllene as an antioxidant, anti-inflammatory and re-epithelialization activities in a rat skin wound excision model
Gushiken, Lucas Fernando Sérgio; Beserra, Fernando Pereira ; Hussni, Maria Fernanda ; Gonzaga, Murilo Tireli ; ; ; ; ; Hussni, Carlos Alberto ; Takahira, Regina Kiomi et al. (Oxidative Medicine and Cellular Longevity, 2022) [Artigo]
The skin is a critical organ for the maintenance of the integrity and protection of the organism. When a wound occurs, a sequence of healing mechanisms is triggered to reconstruct the wounded area. β-caryophyllene is a ... -
Mucinous metaplasia in Pten conditional knockout mice and mucin family genes as prognostic markers for prostate cancer
Santos, Nilton J.; Ximenes, Pedro Pol ; Constantino, Flávia Bessi ; ; Felisbino, Sérgio Luis (Life Sciences, 2022) [Artigo]
Aims: This study evaluated the association of mucinous metaplasia (MM) with tumor cell proliferation, androgen receptor (AR) expression and invasiveness in Pten conditional knockout mice and the prognostic value of MM ... -
Natural Products as Sources of New Analgesic Drugs
Arena, Arielle Cristina; ; ; (Evidence-based Complementary and Alternative Medicine, 2022) [Editorial]
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Genetic markers indicate that hybrids of Pseudoplatystoma (Siluriformes, Pimelodidae) are reproducing in natural environments in southeastern Brazil
Freitas-Souza, Diogo; Nobile, André Batista ; do Prado, Fernanda Dotti ; Serrano, Érica Alves ; Lima, Felipe Pontieri ; Foresti, Fausto ; Porto-Foresti, Fábio ; Oliveira, Claudio (Biological Invasions, 2022) [Artigo]
Due to the constant propagule pressure of invasive species, aquaculture is considered to be one of the principal mechanisms for the introduction of non-native fish species into wild habitats in Brazil. The ongoing expansion ... -
Evaluation of the safety of ethanolic extract from Piper amalago L. (Piperaceae) leaves in vivo: Subacute toxicity and genotoxicity studies
Stein, Julia; Jorge, Bárbara Campos ; Casali Reis, Ana Carolina ; ; da Silva Moreira, Suyane ; ; ; ; ; Arena, Arielle Cristina (Regulatory Toxicology and Pharmacology, 2022) [Artigo]
Piper amalago L. (Piperaceae) is traditionally used due to its anti-inflammatory, analgesic, diuretic, and antiparasitic properties. However, few studies have focused on its adverse effects, compromising its safe use. This ... -
Shedding light on the impacts of gestational exposure to polystyrene nanoplastics on the reproductive performance of Poecilia reticulata female and on the biochemical response of embryos
Malafaia, Guilherme; Nóbrega, Rafael Henrique ; ; (Journal of Hazardous Materials, 2022) [Artigo]
Although the toxicity of nanoplastics (NPs) has already been reported in experimental aquatic models, their possible effects on the reproductive performance of viviparous freshwater fish and their consequences for embryos, ... -
What do environmental advertisers Say and how does the public understand them? Contributions to education for sustainability
; ; Doretto, Lucas Benites; Rosa, Ivana Felipe ; Nóbrega, Rafael Henrique ; (Case Studies in Chemical and Environmental Engineering, 2021) [Artigo]
Different strategies focused on mitigating, remedying, or preventing the intensification of environmental issues have been adopted by several institutions, organizations, governments, media, among others. One of these ... -
Prediction of Non-canonical Routes for SARS-CoV-2 Infection in Human Placenta Cells
Constantino, Flávia Bessi; Cury, Sarah Santiloni ; Nogueira, Celia Regina ; Carvalho, Robson Francisco ; Justulin, Luis Antonio (Frontiers in Molecular Biosciences, 2021) [Artigo]
The SARS-CoV-2 is the causative agent of the COVID-19 pandemic. The data available about COVID-19 during pregnancy have demonstrated placental infection; however, the mechanisms associated with intrauterine transmission ... -
Multidimensional single-nuclei rna-seq reconstruction of adipose tissue reveals adipocyte plasticity underlying thermogenic response
; Cury, Sarah Santiloni; ; ; ; ; Carvalho, Robson Francisco ; (Cells, 2021) [Artigo]
Adipose tissue has been classified based on its morphology and function as white, brown, or beige/brite. It plays an essential role as a regulator of systemic metabolism through paracrine and endocrine signals. Recently, ... -
Drug repositioning based on the reversal of gene expression signatures identifies top2a as a therapeutic target for rectal cancer
Carvalho, Robson Francisco; ; Cury, Sarah Santiloni ; ; ; (Cancers, 2021) [Artigo]
Rectal cancer is a common disease with high mortality rates and limited therapeutic options. Here we combined the gene expression signatures of rectal cancer patients with the reverse drug-induced gene-expression profiles ... -
Fish genomics and its impact on fundamental and applied research of vertebrate biology
Ahmad, Syed Farhan; Jehangir, Maryam ; ; Martins, Cesar (Reviews in Fish Biology and Fisheries, 2021) [Resenha]
The living fishes span a unique and interesting set of animals because of their vast diversity, morphology, ecology, genetics and genomics, and higher importance to biology, economy and culture. During the past decade, the ... -
Maternal protein restriction changes structural and metabolic gene expression in the skeletal muscle of aging offspring rats
Valente, Jéssica Silvino; Perez, Érika Stefani ; Zanella, Bruna Tereza Thomazini ; de Paula, Tassiana Gutierrez ; Dos Santos, Sérgio Alexandre Alcantara ; ; Carvalho, Robson Francisco ; Justulin, Luis Antonio ; Fantinatti, Bruno Evaristo de Almeida ; Dal-Pai-silva, Maeli (Histology and Histopathology, 2021) [Artigo]
Maternal protein restriction affects postnatal skeletal muscle physiology with impacts that last through senility. To investigate the morphological and molecular characteristics of skeletal muscle in aging rats subjected ... -
Accelerated Diversification Explains the Exceptional Species Richness of Tropical Characoid Fishes
Melo, Bruno F.; ; ; Roxo, Fabio F. ; ; Ochoa, Luz E. ; ; ; ; et al. (Systematic Biology, 2022) [Artigo]
The Neotropics harbor the most species-rich freshwater fish fauna on the planet, but the timing of that exceptional diversification remains unclear. Did the Neotropics accumulate species steadily throughout their long ... -
Toxicological evaluation of ethanolic extract of leaves from Doliocarpus dentatus in Swiss mice
; ; ; ; ; ; ; ; Arena, Arielle Cristina; et al. (Drug and Chemical Toxicology, 2021) [Artigo]
Doliocarpus dentatus (Dilleniaceae) has been used in folk medicine to treat inflammation and pain; however, studies evaluating its toxicity potential, as well as its effects on anxiety and depression, are scarce. This study ... -
Exposure to bacteriophages t4 and m13 increases integrin gene expression and impairs migration of human pc-3 prostate cancer cells
Sanmukh, Swapnil Ganesh; Santos, Nilton J. ; Barquilha, Caroline Nascimento ; Dos Santos, Sérgio Alexandre Alcantara ; ; Delella, Flávia Karina ; Moroz, Andrei ; Justulin, Luis Antonio ; ; Felisbino, Sérgio Luis (Antibiotics, 2021) [Artigo]
The interaction between bacteriophages and integrins has been reported in different cancer cell lines, and efforts have been undertaken to understand these interactions in tumor cells along with their possible role in gene ... -
Magnetic 3D cell culture: State of the art and current advances
Caleffi, Juliana Trindade; Aal, Mirian Carolini Esgoti ; Gallindo, Helena de Oliveira Manacorda ; Caxali, Gabriel Henrique ; ; Ribeiro, Amanda Oliveira ; ; Delella, Flávia Karina (Life Sciences, 2021) [Resenha]
Cell culture is an important tool for the understanding of cell biology and behavior. In vitro cultivation has been increasingly indispensable for biomedical, pharmaceutical, and biotechnology research. Nevertheless, with ... -
Exposure of pregnant rats to stress and/or sertraline: Side effects on maternal health and neurobehavioral development of male offspring
Lozano, Ana Flávia Quiarato; Moura, Mayara Silva ; Tavares, Bruna Marques ; Kempinas, Wilma De Grava (Life Sciences, 2021) [Artigo]
Aims: Sertraline (SE) is one of the most prescribed medications for treating gestational depression, anxiety and stress. However, little is known about its effects on nervous-system development in offspring. Therefore, ... -
MicroRNA roles in regeneration: Multiple lessons from zebrafish
Ribeiro, Amanda Oliveira; de Oliveira, Arthur Casulli ; Costa, Juliana Mara ; Nachtigall, Pedro Gabriel ; Herkenhoff, Marcos Edgar ; ; Delella, Flávia Karina ; Pinhal, Danillo (Developmental Dynamics, 2022) [Resenha]
MicroRNAs (miRNAs) are small noncoding RNAs with pivotal roles in the control of gene expression. By comparing the miRNA profiles of uninjured vs. regenerating tissues and structures, several studies have found that miRNAs ...