• A meta-analysis of microRNA networks regulated by melatonin in cancer: Portrait of potential candidates for breast cancer treatment 

  Chuffa, Luiz Gustavo de Almeida ; Carvalho, Robson Francisco ; Justulin, Luis Antônio ; Cury, Sarah Santiloni ; Seiva, Fábio Rodrigues Ferreira; Jardim-Perassi, Bruna Victorasso; Zuccari, Debora Aparecida Pires de Campos; Reiter, Russel J. (Journal of Pineal Research, 2020) [Resenha]

  Melatonin is a ubiquitous molecule with a broad spectrum of functions including widespread anti-cancer activities. Identifying how melatonin intervenes in complex molecular signaling at the gene level is essential to guide ...

• Artepillin C as an outstanding phenolic compound of Brazilian green propolis for disease treatment: A review on pharmacological aspects 

  Beserra, Fernando Pereira ; Gushiken, Lucas Fernando Sérgio ; Hussni, Maria Fernanda ; Ribeiro, Victor Pena; Bonamin, Flávia; Jackson, Christopher John; Pellizzon, Cláudia Helena ; Bastos, Jairo Kenupp (Phytotherapy Research, 2020) [Resenha]

  Propolis is a viscous resin consisting of plant material (shoots, flowers, and plant exudates), salivary secretions and waxes produced by Apis mellifera bees. Its popular use aroused the interests of scientific research, ...

• Blutaparon portulacoides ethanolic extract reduced IL-1β and inflammatory parameters induced by the Mycobacterium complex and carrageenan in mice 

  Kassuya, Roberto Mikio; Radai, Joyce Alencar Santos; Macorini, Luis Fernando Benitez; Nunes, Viktor Krejci; Salvador, Marcos José; Leite, Patricia Regina Terço; Oliveira, Rodrigo Juliano; Croda, Júlio; Arena, Arielle Cristina ; Kassuya, Cândida Aparecida Leite (Inflammopharmacology, 2020) [Artigo]

  Information on the health benefits of ethanolic extracts obtained from Blutaparon portulacoides stem (EEBP) hasn´t been consistently described in the literature until the present moment. This study investigated the ...

• Sorafenib reduces steatosis-induced fibrogenesis in a human 3D co-culture model of non-alcoholic fatty liver disease 

  Romualdo, Guilherme Ribeiro ; Da Silva, Tereza Cristina; de Albuquerque Landi, Marina Frota; Morais, Juliana Ávila; Barbisan, Luis Fernando ; Vinken, Mathieu; Oliveira, Cláudia Pinto; Cogliati, Bruno (Environmental Toxicology, 2020) [Artigo]

  Non-alcoholic fatty liver disease (NAFLD) affects around 25% of the worldwide population. Non-alcoholic steatohepatitis (NASH), the more progressive variant of NAFLD, is characterized by steatosis, cellular ballooning, ...

• New protocol for cell culture to obtain mitotic chromosomes in fishes 

  Paim, Fabilene G. ; Maia, Leandro ; Landim-Alvarenga, Fernanda da Cruz ; Foresti, Fausto ; Oliveira, Claudio (Methods and Protocols, 2018) [Artigo]

  Cell culture is an excellent alternative for the maintenance of cell lines and to obtain quality chromosome preparations of fishes. However, this methodology is still little employed, mainly because of the difficulty of ...

• Panax ginseng metabolite (GIM-1) modulates the effects of monobutyl phthalate (MBP) on the GPR30/GPER1 canonical pathway in human Sertoli cells 

  de Freitas, André Teves A.G. ; Pinho, Cristiane Figueiredo ; Aquino, Ariana Musa ; Domeniconi, Raquel Fantin ; Justulin, Luis Antonio ; Scarano, Wellerson Rodrigo (Reproductive Toxicology, 2020) [Artigo]

  This study was performed to evaluate the effect of monobutyl phthalate (MBP) on GPR30-activated pathways in Sertoli cells. Additionally, we tested if GIM-1 (Panax ginseng metabolite) modulates MBP action. Human Sertoli ...

• Impact of timing of the anorexigen sibutramine administration on reproductive end-points of male rats 

  Borges, Cibele S. ; Silva, Patrícia V. ; Lozano, Ana Flávia Q. ; Missassi, Gabriela ; Silva, Raquel F. ; Anselmo-Franci, Janete A.; Kempinas, Wilma G. (Basic and Clinical Pharmacology and Toxicology, 2020) [Artigo]

  Sibutramine is a non-selective serotonin-norepinephrine reuptake inhibitor orally administered for weight loss. In a previous study, we showed pharmacological mechanisms involved in the reduction of sperm quality and ...

• Pre-pubertal exposure to ibuprofen impairs sperm parameters in male adult rats and compromises the next generation 

  Barbosa, Mariana Gazoli ; Jorge, Bárbara Campos ; Stein, Julia ; Santos Ferreira, Dayana Agnes ; Barreto, Ana Carolina da Silva ; Reis, Ana Carolina Casali ; Moreira, Suyane Da Silva ; Inocencio, Leonardo Cesar De Lima ; Macorini, Luis Fernando Benitez; Arena, Arielle Cristina (Journal of Toxicology and Environmental Health - Part A: Current Issues, 2020) [Artigo]

  Ibuprofen is one of the most commonly prescribed anti-inflammatory drugs in pediatric practice. This drug inhibits the cyclooxygenase enzyme, reducing the production of prostaglandin, an important mediator on male reproductive ...

• Lorcaserin Administration has Pro-Ejaculatory Effects in Rats via 5-HT2C Receptors Activation: A Putative Pharmacologic Strategy to Delayed Ejaculation? 

  de Almeida Kiguti, Luiz Ricardo; Pacheco, Tainá Louise ; Antunes, Edson; Kempinas, Wilma de Grava (Journal of Sexual Medicine, 2020) [Artigo]

  Background: Lorcaserin is an anti-obesity drug whose weight loss effect results from 5-hydroxytryptamin (5-HT)2C receptors activation. The 5-HT2C receptor was shown to participate in the physiological control of ejaculation, ...

• Effects of isolated or combined exposure to sibutramine and rosuvastatin on reproductive parameters of adult male rats 

  e Silva, Patrícia Villela ; Borges, Cibele dos Santos ; Rosa, Josiane de Lima ; Pacheco, Tainá Louise ; Figueiredo, Thamiris Moreira ; Leite, Gabriel Adan Araújo; Guerra, Marina Trevizan ; Anselmo-Franci, Janete Aparecida; Klinefelter, Gary Robert; Kempinas, Wilma De Grava (Journal of Applied Toxicology, 2020) [Artigo]

  Many obese patients are exposed to hypolipidemic and serotonin-norepinephrine reuptake inhibitor (SNRI) drugs. Statins are one of the most marketed drugs in the world to treat dyslipidemia, while sibutramine, a SNRI drug, ...

• DNA barcode reveals the illegal trade of rays commercialized in fishmongers in Brazil 

  Camacho-Oliveira, Raul B. ; Daneluz, Cahique M. ; do Prado, Fernanda D. ; Utsunomia, Ricardo ; Rodrigues, Carlos E.; Foresti, Fausto ; Porto-Foresti, Fábio (Forensic Science International: Synergy, 2020) [Artigo]

  Sequences of the mitochondrial gene COI (DNA Barcode) were used to identify species of rays and skates commercialized in fishmongers in Brazil. The comparisons of the obtained sequences with previously published data ...

• Increased DSG2 plasmatic levels identified by transcriptomic-based secretome analysis is a potential prognostic biomarker in laryngeal carcinoma 

  Cury, Sarah Santiloni ; Lapa, Rainer Marco Lopez ; de Mello, Julia Bette Homem; Marchi, Fábio Albuquerque; Domingues, Maria Aparecida Custódio ; Pinto, Clóvis Antonio Lopes; Carvalho, Robson Francisco ; de Carvalho, Genival Barbosa; Kowalski, Luiz Paulo; Rogatto, Silvia Regina (Oral Oncology, 2020) [Artigo]

  Objectives: The tumor secretome deconvolution is a promising strategy to identify diagnostic and prognostic biomarkers. Here, transcriptomic-based secretome analysis was performed aiming to discover laryngeal squamous cell ...

• Fractal analysis and histomolecular phenotyping provides insights into extracellular matrix remodeling in the developing bovine fetal ovary 

  Franchi, Fernanda Fagali ; Hernandes, Mariana Pelicho; Coalho Ferreira, Amanda Leticia; Vieira de Lima, Victor Augusto; de Oliveira Mendes, Leonardo; Musa de Aquino, Ariana ; Scarano, Wellerson Rodrigo ; César de Souza Castilho, Anthony (Biochemical and Biophysical Research Communications, 2020) [Artigo]

  Although studies have focused on extracellular matrix (ECM) remodeling during the formation and functioning of adult ovaries, there is no comprehensive understanding of the mechanisms controlling preantral follicle development ...

• Status and recommendations for sustainable freshwater aquaculture in Brazil 

  Nobile, André B. ; Cunico, Almir M.; Vitule, Jean R. S.; Queiroz, Jamile; Vidotto-Magnoni, Ana P.; Garcia, Diego A. Z.; Orsi, Mário L.; Lima, Felipe P. ; Acosta, Aline A.; da Silva, Reinaldo J. et al. (Reviews in Aquaculture, 2020) [Resenha]

  Brazil is a megadiverse country and is participant of fundamental environmental agreements for biodiversity conservation. However, the internal politics and the cultures that affect negatively the ecological integrity in ...

• IGS sequences in Cestrum present AT- and GC-rich conserved domains, with strong regulatory potential for 5S rDNA 

  de Souza, Thaíssa Boldieri; Gaeta, Marcos Letaif; Martins, Cesar ; Vanzela, André Luís Laforga (Molecular Biology Reports, 2020) [Artigo]

  The 35S and 5S ribosomal DNA (rDNA) organized in thousands of copies in genomes, have been widely used in numerous comparative cytogenetic studies. Nevertheless, several questions related to the diversity and organization ...

• Reproductive cycle of the tetra Astyanax bimaculatus (Characiformes: Characidae) collected in Amazonian streams 

  Cordeiro, Jhennifer Gomes; Rodrigues, Jeane; Rodrigues, Maira Da Silva ; Bertolini, Rafaela Manchin; Nóbrega, Rafael Henrique ; Yasui, George Shigueki; Maximino, Caio; Siqueira-Silva, Diógenes Henrique De (Zygote, 2019) [Artigo]

  SummaryA histological characterization of gonadal development in the tetra Astyanax bimaculatus was performed, aimed at determining its reproductive cycle in streams localized inside the Amazonian forest. Collections were ...

• The influence of increased water temperature on the duration of spermatogenesis in a neotropical fish, Astyanax altiparanae (Characiformes, Characidae) 

  Postingel Quirino, Patricia ; da Silva Rodrigues, Maira ; da Silva Cabral, Elis Marina ; de Siqueira-Silva, Diógenes Henrique; Mori, Ricardo Hideo ; Butzge, Arno Juliano ; Nóbrega, Rafael Henrique ; Ninhaus-Silveira, Alexandre ; Veríssimo-Silveira, Rosicleire (Fish Physiology and Biochemistry, 2020) [Artigo]

  In view of the established climate change scenario and the consequent changes in global temperature, it is essential to study its effects on animal spermatogenesis. Therefore, the aim of this study was to verify the duration ...

• Myology of juvenile freshwater prawn Macrobrachium amazonicum (Decapoda, Caridea): Morphology and swimming implication 

  Ruiz, Thalles Fernando Rocha ; Gois, Gabriel Vieira Martins Rezende ; Rocha, João Candido Rodrigues ; Vidal, Mateus Rossetto ; Gardinal, Mario Vitor Buzete ; Vicentini, Carlos Alberto ; Franceschini Vicentini, Irene Bastos (Arthropod Structure and Development, 2020) [Artigo]

  Little is known about the functional morphology of locomotion in prawns, and even fewer studies have succeeded in relating a specific muscular group to the movement of the body. The present study aimed to describe the ...

• Zygoparity in characidae-the first case of internal fertilization in the teleost cohort otomorpha 

  Fukakusa, Clayton Kunio; Mazzoni, Talita Sarah ; Malabarba, Luiz Roberto (Neotropical Ichthyology, 2020) [Artigo]

  Most teleosts are externally fertilizing, with internal fertilization occurring as a relatively rare event. Until now, Euteleosteomorpha is the only teleost cohort known to undergo internal fertilization. In the teleost ...

• Increased angiotensin II from adipose tissue modulates myocardial collagen I and III in obese rats 

  da Silva-Bertani, Danielle Cristina Tomaz ; Vileigas, Danielle Fernandes ; Mota, Gustavo Augusto Ferreira ; de Souza, Sérgio Luiz Borges ; Sant'Ana, Paula Grippa ; Freire, Paula Paccielli ; de Tomasi, Loreta Casquel ; Corrêa, Camila Renata ; Padovani, Carlos Roberto ; Fernandes, Tiago et al. (Life Sciences, 2020) [Artigo]

  It has been described that the cardiac dysfunction in the obesity model is because of collagen imbalance and that angiotensin II (Ang II) contributes to myocardial fibrosis. However, it remains undefined if changes in ...

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