Mensuração da dimetilarginina simétrica em gatos assintomáticos e sintomáticos para doença renal crônica.
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Data
2019-07-30
Autores
Reis, Gisele Fabricia Martins dos
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Universidade Estadual Paulista (Unesp)
Resumo
O objetivo desta pesquisa foi avaliar o comportamento dos biomarcadores renais dimetilarginina simétrica (SDMA), creatinina sérica (CRs) e a relação proteína:creatinina urinária (UPC) em gatos aparentemente saudáveis (n: 20) e gatos portadores de doença renal crônica (n:10). No grupo de gatos com doença renal crônica (DRC) os valores médios de SDMA, CRs e UPC foram 20,4 ± 3,1 µg/dL, 2,4 ± 0,7 mg/dl e 0,6 ± 0,23, respectivamente. Para o grupo aparentemente saudável a SDMA, CRs e UPC obtidos foram 9,8 ± 1,8 µg/dL, 0,9 ± 0,4 mg/dl e 0,28 ± 0,08. Para o grupo positivo para DRC, o coeficiente de correlação entre a SDMA e CRs foi r = 0,52, indicando ser correlação moderada entre estes marcadores renais. Pelo exposto conclui-se que os gatos sintomáticos para DRC necessitam serem subestadiados pelos critérios da IRIS (2017) (UPC, CRs, PAS e SDMA) e execução de medidas de renoproteção como tentativa de controle da progressão da DRC presente. Para os gatos aparentemente saudáveis o comportamento da SDMA deu-se dentro da normalidade para a espécie, com um valor de UPC limítrofe, sugerindo monitoramento e acompanhamento trimestral ou semestral, conforme avaliação clínica.
The objective of this study was to evaluate the behavior of the renal biomarkers dimethylarginine symmetric (SDMA), serum creatinine (CRs) and protein: urinary creatinine ratio (UPC) in apparently healthy cats (n: 20) and cats with chronic kidney disease (10). In the group of cats with chronic kidney disease (CKD) the mean values of SDMA, CRs and UPC were 20,4 ± 3,1μg / dL, 2,4 ± 0,7 mg / dl and 0,6 ± 0,23, respectively. In the apparently healthy group the SDMA, CRs and UPC obtained were 9,8 ± 1,8 μg / dL, 0,9 ± 0,4 mg/dl and 0,28 ± 0,08. In the group of cats with chronic kidney disease the correlation of SDMA and CRs was r = 0.52, indicating a moderate correlation between these renal biomarkers. Based on those findings concluded that cats with CKD require a detailed diagnosis by IRIS (2017) (UPC, CRs, PAS and SDMA) to perform kidney protection and attempt to control the progression of CKD. For apparently healthy cats, the behavior of SDMA was the normal range for the species, with a borderline UPC value, suggesting monitoring and quarterly or semi-annual follow-up, according to clinical evaluation.
The objective of this study was to evaluate the behavior of the renal biomarkers dimethylarginine symmetric (SDMA), serum creatinine (CRs) and protein: urinary creatinine ratio (UPC) in apparently healthy cats (n: 20) and cats with chronic kidney disease (10). In the group of cats with chronic kidney disease (CKD) the mean values of SDMA, CRs and UPC were 20,4 ± 3,1μg / dL, 2,4 ± 0,7 mg / dl and 0,6 ± 0,23, respectively. In the apparently healthy group the SDMA, CRs and UPC obtained were 9,8 ± 1,8 μg / dL, 0,9 ± 0,4 mg/dl and 0,28 ± 0,08. In the group of cats with chronic kidney disease the correlation of SDMA and CRs was r = 0.52, indicating a moderate correlation between these renal biomarkers. Based on those findings concluded that cats with CKD require a detailed diagnosis by IRIS (2017) (UPC, CRs, PAS and SDMA) to perform kidney protection and attempt to control the progression of CKD. For apparently healthy cats, the behavior of SDMA was the normal range for the species, with a borderline UPC value, suggesting monitoring and quarterly or semi-annual follow-up, according to clinical evaluation.
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Palavras-chave
Gatos domésticos, Insuficiência renal crônica, Marcadores bioquímicos, Cat, Renal, Biomarkers