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dc.contributor.authorLima, N. M.
dc.contributor.authorFalcoski, T. O.R. [UNESP]
dc.contributor.authorSilveira, R. S.
dc.contributor.authorRamos, R. R.
dc.contributor.authorAndrade, T. J.A.S.A.
dc.contributor.authorCosta, P. I.
dc.contributor.authorLa Porta, F. A.
dc.contributor.authorAlmeida, M. V.A.
dc.date.accessioned2019-10-06T15:38:08Z
dc.date.available2019-10-06T15:38:08Z
dc.date.issued2019-01-01
dc.identifierhttp://dx.doi.org/10.1080/14786419.2019.1591395
dc.identifier.citationNatural Product Research.
dc.identifier.issn1478-6427
dc.identifier.issn1478-6419
dc.identifier.urihttp://hdl.handle.net/11449/187503
dc.description.abstractThe extraction conditions and chromatographic analysis from seeds of Inga edulis were optimized and provided one anthocyanin from aqueous fraction and a mixture of three anthocyanins from methanolic fraction. The pure anthocyanin obtained was subjected to structural modifications and the products obtained were subjected to chemical and pharmacological assays, as well as quantum chemical calculations based on DFT and TD-DFT methods. Hence, the anthocyanin fractions were evaluated for their chemical-pharmacological potential through chemical and biological assays: antioxidant activity by the DPPH, determination of the Solar Protection Factor (SPF) and cytotoxic activity (hepatocellular carcinoma infected with hepatitis C virus). The results indicated that even the anthocyanin and derivatized compounds having high antioxidant potential showed an SPF lower than six, which is lower than the minimum accepted by current Brazilian legislation. In addition, none of compounds presented significant cytotoxic activity against the tumour cell line studied.en
dc.language.isoeng
dc.relation.ispartofNatural Product Research
dc.sourceScopus
dc.subjectantioxidant
dc.subjectcytotoxicity
dc.subjectInga edulis
dc.subjectnatural products
dc.subjecttheoretical aspects
dc.titleInga edulis fruits: a new source of bioactive anthocyaninsen
dc.typeArtigo
dc.contributor.institutionUniversidade Federal de Viçosa (UFV)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionCiência e Tecnologia do Maranhão
dc.contributor.institutionUniversidade Tecnológica Federal do Paraná (UTFPR)
dc.contributor.institutionUniversidade Federal de Juiz de Fora
dc.description.affiliationInstituto de Ciência Engenharia e Tecnologia Laboratório de Bioquímica Universidade Federal dos Vales do Jequitinhonha e Mucuri (UFVJM)
dc.description.affiliationFaculdade de Farmácia Universidade Estadual Paulista “Júlio de Mesquita Filho” (UNESP)
dc.description.affiliationNIAC-Núcleo de Investigação Aplicado às Ciências-Instituto Federal de Educação Ciência e Tecnologia do Maranhão Campus Timon (IFMA)
dc.description.affiliationDepartamento de Química Universidade Tecnológica Federal do Paraná (UTFPR)
dc.description.affiliationDepartamento de Química Universidade Federal de Juiz de Fora
dc.description.affiliationUnespFaculdade de Farmácia Universidade Estadual Paulista “Júlio de Mesquita Filho” (UNESP)
dc.identifier.doi10.1080/14786419.2019.1591395
dc.rights.accessRightsAcesso aberto
dc.identifier.scopus2-s2.0-85063630767
dc.identifier.lattes6720223715917381
dc.identifier.orcid0000-0002-3350-8308
unesp.author.lattes6720223715917381[6]
unesp.author.orcid0000-0002-3350-8308[6]
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