Bisphenol-S promotes endocrine-disrupting effects similar to those promoted by bisphenol-A in the prostate of adult gerbils
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Data
2019-04-01
Autores
Silva, João Paulo Assis
Ramos, Jordana Gomes
Campos, Mônica Sousa
da Silva Lima, Danilo
de Azevedo Brito, Pedro Vale
Mendes, Elizabeth Pereira
Taboga, Sebastião Roberto [UNESP]
Biancardi, Manoel Francisco
Ghedini, Paulo César
Santos, Fernanda Cristina Alcantara
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Resumo
This study evaluated the effects of BPS (40 μg/kg/day, during 28 consecutive days) on the male ventral prostate and female prostate of adult gerbils. For comparative purposes, gerbils were also exposed to BPA under the same experimental conditions. The prostates were submitted to biometric, morphometric, histopathological, immunohistochemical and ultrastructural analyses. The results demonstrated that exposure to both types of bisphenol caused no changes in testosterone or estradiol serum levels. Morphologically, the effects of BPS and BPA on female prostates were similar and included changes in prostatic tissue compartments, glandular hyperplasia, AR and ERα up-regulation and increased cell proliferation. In males, BPS and BPA promoted differential effects, since the prostate presented morphological changes and proliferative disorders that were more pronounced in the BPS group. Therefore, this study demonstrates that BPS caused endocrine disruption in the prostate of male and female gerbils.
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Androgen receptor, Endocrine-disrupting chemicals, Estrogen receptor, Morphology, Reproduction
Como citar
Reproductive Toxicology, v. 85, p. 83-92.