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dc.contributor.authorFioretto, Jose Roberto [UNESP]
dc.contributor.authorPires, Rafaelle Batistella
dc.contributor.authorKlefens, Susiane Oliveira [UNESP]
dc.contributor.authorKurokawa, Cilmery Suemi [UNESP]
dc.contributor.authorCarpi, Mario Ferreira [UNESP]
dc.contributor.authorBonatto, Rossano César [UNESP]
dc.contributor.authorMoraes, Marcos Aurélio [UNESP]
dc.contributor.authorRonchi, Carlos Fernando [UNESP]
dc.date.accessioned2019-10-06T17:07:08Z
dc.date.available2019-10-06T17:07:08Z
dc.date.issued2019-01-01
dc.identifierhttp://dx.doi.org/10.1590/1806-3713/e20180067
dc.identifier.citationJornal Brasileiro de Pneumologia, v. 45, n. 5, 2019.
dc.identifier.issn1806-3756
dc.identifier.issn1806-3713
dc.identifier.urihttp://hdl.handle.net/11449/190250
dc.description.abstractObjective: To compare the effects that prone and supine positioning during high-frequency oscillatory ventilation (HFOV) have on oxygenation and lung inflammation, histological injury, and oxidative stress in a rabbit model of acute lung injury (ALI). Methods: Thirty male Norfolk white rabbits were induced to ALI by tracheal saline lavage (30 mL/kg, 38°C). The injury was induced during conventional mechanical ventilation, and ALI was considered confirmed when a PaO2 /FiO2 ratio < 100 mmHg was reached. Rabbits were randomly divided into two groups: HFOV in the supine position (SP group, n = 15); and HFOV with prone positioning (PP group, n = 15). For HFOV, the mean airway pressure was initially set at 16 cmH2 O. At 30, 60, and 90 min after the start of the HFOV protocol, the mean airway pressure was reduced to 14, 12, and 10 cmH2 O, respectively. At 120 min, the animals were returned to or remained in the supine position for an extra 30 min. We evaluated oxygenation indices and histological lung injury scores, as well as TNF-α levels in BAL fluid and lung tissue. Results: After ALI induction, all of the animals showed significant hypoxemia, decreased respiratory system compliance, decreased oxygenation, and increased mean airway pressure in comparison with the baseline values. There were no statistically significant differences between the two groups, at any of the time points evaluated, in terms of the PaO2 or oxygenation index. However, TNF-α levels in BAL fluid were significantly lower in the PP group than in the SP group, as were histological lung injury scores. Conclusions: Prone positioning appears to attenuate inflammatory and histological lung injury during HFOV in rabbits with ALI.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.language.isoeng
dc.relation.ispartofJornal Brasileiro de Pneumologia
dc.sourceScopus
dc.subjectAcute lung injury
dc.subjectAdult
dc.subjectAnimal
dc.subjectArtificial/adverse effects
dc.subjectDisease models
dc.subjectLung/physiopathology
dc.subjectPneumonia
dc.subjectProne position
dc.subjectRabbits
dc.subjectRespiration
dc.subjectRespiratory distress syndrome
dc.titleInflammatory lung injury in rabbits: Effects of high-frequency oscillatory ventilation in the prone positionen
dc.typeArtigo
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de Uberlândia (UFU)
dc.description.affiliationFaculdade de Medicina de Botucatu Universidade Estadual Paulista – UNESP
dc.description.affiliationHospital de Reabilitação de Anomalias Craniofaciais Universidade de São Paulo
dc.description.affiliationDepartamento de Fisioterapia Universidade Federal de Uberlândia
dc.description.affiliationUnespFaculdade de Medicina de Botucatu Universidade Estadual Paulista – UNESP
dc.identifier.doi10.1590/1806-3713/e20180067
dc.identifier.scieloS1806-37132019000500200
dc.rights.accessRightsAcesso aberto
dc.description.sponsorshipIdFAPESP: 2010/06242-8
dc.identifier.scopus2-s2.0-85063971843
dc.identifier.fileS1806-37132019000500200.pdf
dc.identifier.lattes3929692206834380
dc.identifier.lattes0246391303241376
dc.identifier.lattes8510423269540465
dc.identifier.orcid0000-0002-0648-876X
dc.identifier.orcid0000-0003-1380-7527
unesp.author.lattes3929692206834380
unesp.author.lattes0246391303241376[6]
unesp.author.lattes8510423269540465[4]
unesp.author.orcid0000-0003-4034-5962[1]
unesp.author.orcid0000-0002-3961-5534[2]
unesp.author.orcid0000-0002-4988-8317[3]
unesp.author.orcid0000-0003-1380-7527[4]
unesp.author.orcid0000-0002-1482-564X[5]
unesp.author.orcid0000-0002-0648-876X[6]
unesp.author.orcid0000-0003-0007-1506[7]
unesp.author.orcid0000-0002-5927-9320[8]
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