Novel polymeric dressing to the treatment of infected chronic wound
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Data
2019-06-18
Autores
Garms, Bruna Cambraia [UNESP]
Borges, Felipe Azevedo [UNESP]
de Barros, Natan Roberto [UNESP]
Marcelino, Mônica Yonashiro [UNESP]
Leite, Marcel Nani
Del Arco, Marina Constante
de Souza Salvador, Sérgio Luiz
Pegorin, Giovana Sant’Ana [UNESP]
Oliveira, Kassandra Sussi Mustafé [UNESP]
Frade, Marco Andrey Cipriani
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Resumo
Natural rubber latex (NRL) is a natural polymer which has arisen large interest in the biomedical field, mostly, due to its ability to facilitate angiogenesis and therefore, tissue repair. Moxifloxacin (MXF) is a broad-spectrum antibiotic orally administrated. Considering the biological properties of the NRL and its ability to deliver a wide range of compounds, the present study aimed to develop a novel device for infected chronic wound treatment. MXF-loaded NRL was obtained by a casting method. The results demonstrated that the incorporation of MXF in NRL did not promote any molecular interaction, preserving the integrity of the compounds. The mechanical properties of the biomaterial did not show any significant change, indicating enough elasticity for dermal application. The microbiological assays confirmed the ability of the polymer to deliver the drug without influencing its pharmacological properties. Moreover, it has expressed activity against major bacterial strains presented in wound infections. Finally, the biomaterial shown biocompatibility from the in vitro study. Thus, the present work has shown that MXF-loaded NRL membrane is a promising biomaterial to infected wound treatment.
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Palavras-chave
Antibiotic, Moxifloxacin, Natural rubber latex, Skin infection, Wound healing
Como citar
Applied Microbiology and Biotechnology, v. 103, n. 12, p. 4767-4778, 2019.