Cost-effectiveness of Prophylactic Zika Virus Vaccine in the Americas
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2019-12-01
Autores
Shoukat, Affan
Vilches, Thomas [UNESP]
Moghadas, Seyed M.
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Centers Disease Control & Prevention
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Zika virus remains a major public health concern because of its association with microcephaly and other neurologic disorders in newborns. A prophylactic vaccine has the potential to reduce disease incidence and eliminate birth defects resulting from prenatal Zika virus infection in future outbreaks. We evaluated the cost-effectiveness of a Zika vaccine candidate, assuming a protection efficacy of 60%-90%, for 18 countries in the Americas affected by the 2015-2017 Zika virus outbreaks. Encapsulating the demographics of these countries in an agent-based model, our results show that vaccinating women of reproductive age would be very cost-effective for sufficiently low (<$16) vaccination costs per recipient, depending on the country-specific Zika attack rate. In all countries studied, the median reduction of microcephaly was >75% with vaccination. These findings indicate that targeted vaccination of women of reproductive age is a noteworthy preventive measure for mitigating the effects of Zika virus infection in future outbreaks.
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Emerging Infectious Diseases. Atlanta: Centers Disease Control & Prevention, v. 25, n. 12, p. 2191-2196, 2019.