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dc.contributor.authorBiancardi, Manoel F.
dc.contributor.authorSantos, Fernanda C. A.
dc.contributor.authorMadi-Ravazzi, Liliam [UNESP]
dc.contributor.authorGoes, Rejane M. [UNESP]
dc.contributor.authorVilamaior, Patricia S. L.
dc.contributor.authorFelisbino, Sergio L. [UNESP]
dc.contributor.authorTaboga, Sebastiao R. [UNESP]
dc.identifier.citationAnatomical Record-advances In Integrative Anatomy and Evolutionary Biology. Malden: Wiley-blackwell, v. 293, n. 12, p. 2163-2175, 2010.
dc.description.abstractThe female prostate (Skene's paraurethral gland) in the rat is morphologically similar to the ventral lobe of male adults and has been described in other rodent species and humans. Previous studies on prostate morphogenesis suggest that female Wistar rats (Rattus norvegicus) do not develop this gland due to the absence of testosterone during the embryonic and neonatal periods. on the other hand, studies conducted in our laboratory have shown that some females of this species can present an undeveloped but functional prostate. Recent studies on this gland have caused scientific interest because, besides being active in the processes of synthesis and secretion of prostatic material, it is also targeted by both malignant and benign lesions, mainly during senescence. Thus, this work aims to evaluate the structure of female prostate of adult rats (Rattus norvegicus) under normal conditions and under the effect of testosterone treatment and carry out comparative studies on the ventral prostate of young and adult male rats. Morphological and morphometric stereological analyses and immunocytochemical and ultrastructural studies were conducted. The results have shown that the prostate gland of rats exposed to androgen therapy have experienced intense growth, becoming more active in relation to synthesis and secretion. It may be concluded that the prostate in control adult female rats is morphologically very similar to the prostatic ventral lobe of young male rats. Besides, under androgenic action, the female prostate grows considerably and becomes similar to the prostatic ventral lobe in male adults. Anat Rec, 293:2163-2175, 2010. (C) 2010 Wiley-Liss, Inc.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.relation.ispartofAnatomical Record-advances In Integrative Anatomy and Evolutionary Biology
dc.sourceWeb of Science
dc.subjectfemale prostateen
dc.subjectventral male prostateen
dc.titleTestosterone Promotes an Anabolic Increase in the Rat Female Prostate (Skene's Paraurethral Gland) Which Acquires a Male Ventral Prostate Phenotypeen
dc.contributor.institutionInst Biol
dc.contributor.institutionUniversidade Federal de Goiás (UFG)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.description.affiliationInst Biol, Dept Cell Biol, Campinas, SP, Brazil
dc.description.affiliationUniversidade Federal de Goiás (UFG), Dept Morphol, Goiania, Go, Brazil
dc.description.affiliationSão Paulo State Univ, UNESP IBILCE, Dept Biol, Lab Microscopy & Microanal, São Paulo, Brazil
dc.description.affiliationUNIRP, Rio Preto Universitary Ctr, Biol Sci & Vet Med Sch, São Paulo, Brazil
dc.description.affiliationSão Paulo State Univ, UNESP IB, Inst Biol, São Paulo, Brazil
dc.description.affiliationUnespSão Paulo State Univ, UNESP IBILCE, Dept Biol, Lab Microscopy & Microanal, São Paulo, Brazil
dc.description.affiliationUnespSão Paulo State Univ, UNESP IB, Inst Biol, São Paulo, Brazil
dc.rights.accessRightsAcesso aberto
dc.description.sponsorshipIdFAPESP: 05/04647-2
dc.description.sponsorshipIdFAPESP: 06/06876-1
dc.description.sponsorshipIdFAPESP: 07/06862-3
dc.description.sponsorshipIdCNPq: 301111/05-7
dc.description.sponsorshipIdCNPq: 300163/2008-8
dc.description.sponsorshipIdCNPq: 302693/2008-4
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