In vitro antifungal susceptibility of Candida spp. oral isolates from HIV-positive patients and control individuals
Carregando...
Data
2011-01-01
Autores
Back Brito, Graziella Nuernberg [UNESP]
Inocencio, Aline Cassia [UNESP]
Rodrigues Querido, Silvia Maria [UNESP]
Cardoso Jorge, Antonio Olavo [UNESP]
Koga-Ito, Cristiane Yumi [UNESP]
Título da Revista
ISSN da Revista
Título de Volume
Editor
Sociedade Brasileira de Pesquisa Odontológica (SBPqO)
Resumo
Oropharyngeal candidiasis is the most common fungal infection among HIV-positive patients. This condition can be treated with either systemic or topical antifungal agents; treatments are usually indicated empirically on the basis of clinical data. The knowledge of in vitro antifungal susceptibility is important to determine correct therapeutic guides for the treatment of fungal infections. Therefore, the objective of this study was to determine the antifungal susceptibility profile of oral Candida isolates from HIV-positive patients and control individuals. Amphotericin B, fluconazole, flucytosine, nystatin and ketoconazole were tested according to the methodology of microdilution proposed by the Clinical and Laboratory Standards Institute (CLSI); results were recorded in values of minimal inhibitory concentration (MIC). A total of 71 Candida isolates from HIV-positive patients were examined with the following species represented: C. albicans (59), C. tropicalis (9), C. glabrata (1), C. guilliermondii (1) and C. krusei (1). A total of 15 Candida isolates were evaluated from control individuals comprised of 11 C. albicans and 4 C. tropicalis samples. Our results demonstrated that the tested antifungal agents showed good activity for most isolates from both groups; however, variability in MIC values among isolates was observed.
Descrição
Palavras-chave
HIV, Antifungal Agents, Candida
Como citar
Brazilian Oral Research. São Paulo: Sociedade Brasileira de Pesquisa Odontologica, v. 25, n. 1, p. 28-33, 2011.