Subacute exposure to aluminum chloride causes prolonged morphological insults in the ventral male prostate and in the female prostate of adult gerbils
Nenhuma Miniatura disponível
Data
2022-02-01
Autores
da Silva Lima, Danilo
da Silva Gomes, Liana
de Sousa Figueredo, Esther
e Silva, Yasmin Inocêncio Fernandes
Silva, Edvaldo Mendes
de Souza Bovi, Thais
Taboga, Sebastião Roberto [UNESP]
Marques, Mara Rúbia
Biancardi, Manoel Francisco
dos Santos, Fernanda Cristina Alcantara
Título da Revista
ISSN da Revista
Título de Volume
Editor
Resumo
Aluminum (Al) is a widespread metal in the environment, and is found in fresh or processed foods, household utensils, packaging, and medicines. In addition to its high toxicity, Al can also have estrogenic agonistic effects on target organs. Considering that the Al effects on the prostate are little known, the aim of this study was to evaluate the impact of aluminum chloride (AlCl3) subacute exposure on the morphophysiology of the male ventral prostate and the female prostate of adult gerbils. Furthermore, the glandular restoration capacity in face of the Al insults was evaluated in gerbils that were submitted to 30 days of recovery. Male and female gerbils were orally exposed to AlCl3 (10 mg/kg) for 30 consecutive days. The animals were euthanized 1 day (Al1D) or 30 days (Al30D) after the end of treatment. Prostates were dissected out and processed for structural, ultrastructural and immunohistochemical analyses. Male ventral prostates and female prostates of the Al1D group showed increased cell proliferation, glandular hyperplasia, increased secretory activity and greater androgen receptor immunoreactivity. In males, Al withdrawal (Al30D) allowed a partial recovery of the prostate, as the glandular secretory activity, and frequency of androgen receptor positive cells were similar to the control group. In females, the recuperation interval (Al30D) was not enough to restore the prostatic morphology, since the gland remained hyperplastic, proliferative, and with greater androgen and estrogen receptor immunoreactivity. These data alert to the importance of avoiding Al exposure, since this metal can have a harmful and prolonged action on the prostate.
Descrição
Palavras-chave
Como citar
Environmental Toxicology, v. 37, n. 2, p. 299-309, 2022.