The role of qualea multiflora on mammary tumour cells and immune system
Nenhuma Miniatura disponível
Data
2013-09-01
Autores
Carli, Camila B. de A. [UNESP]
Quilles, Marcela Bassi [UNESP]
Vilegas, Wagner [UNESP]
Carlos, Iracilda Z. [UNESP]
Título da Revista
ISSN da Revista
Título de Volume
Editor
Resumo
Species of the genus Qualea are used by the Brazilian public as a natural anti-inflammatory. Based on this evidence, we evaluated the effects of terpene fractions (βF and TF) obtained from Qualea multiflora on nitric oxide production (Griess assay), cytokines (IL-1, IL-10, IL-12, and TNF-α) and the transcription factor NF-KB by peritoneal macrophages. Since there is a relationship between inflammation and cancer, the cytotoxicity of βF and TF against mammary tumoural cell lineage, and macrophages was evaluated. Inhibition levels close to 90% of the production of NO, IL-1, IL-12 and TNF-α; about 32% of NF-KB; and a large stimulation of IL-10 production (close to the positive control) by peritoneal macrophages were observed in response to βF and TF which are correlated with anti-inflammatory activity. Additionally, the samples showed exceptional cytotoxic activity against tumoural cells but not against macrophages. Since anti-inflammatory activity is important in tumour inhibition, further examination of potential anti-cancerous activity of Qualea multiflora is warranted. © 2013 Camila B. de A. Carli et al.
Descrição
Palavras-chave
Cancer, Macrophages, Q. multiflora
Como citar
Journal of Applied Pharmaceutical Science, v. 3, n. 9, p. 8-13, 2013.