Esteroide e triterpenos de espécies de qualea-bioatividade sobre mycobacterium tuberculosis
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Data
2013-01-01
Autores
Nasser, Ana Lucia Martiniano [UNESP]
Pavan, Fernando Rogério [UNESP]
Boralle, Nivaldo [UNESP]
Zocolo, Guilherme Julião [UNESP]
Dos Santos, Lourdes Campaner [UNESP]
de Marchi, Mary Rosa Rodrigues [UNESP]
Leite, Clarice Queico Fujimura [UNESP]
Vilegas, Wagner [UNESP]
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Resumo
The chloroform extract of bark of the tropical tree Qualea parviflora (Vochysiaceae) was fractionated by column chromatography on silica gel, yielding triterpenes (lupeol, lupenone, betulin, epi-betulinic acid and friedelin) and a steroid (β-sitosterol). β-sitosterol, lupenone and lupeol were also identified in Q. grandiflora and Q. multiflora, while friedelin was detected only in Q. Multiflora, by means of gas chromatography-mass spectrometry. The anti-Mycobacterium tuberculosis activity of the chloroform extract and isolated compounds was assayed by MABA and MIC values ranged from 250.0 to 31.2 μg/mL. This study is the first to investigate the chemistry and antitubercular activity of apolar compounds from Qualea species.
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Anti-mycobacterium tuberculosis activity, Qualea species, Triterpenes
Como citar
Revista de Ciencias Farmaceuticas Basica e Aplicada, v. 34, n. 4, p. 513-517, 2013.