A frequência de pré-hipertensão e estresse oxidativo aumentam em gatos obesos
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Data
2022-08-19
Autores
Valadares, Taiana Carvalho
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Editor
Universidade Estadual Paulista (Unesp)
Resumo
A causa fundamental da obesidade é a ingestão de alimentos com alta densidade energética e a inatividade que levam ao desbalanço entre consumo e gasto calórico. A hipertensão relacionada a obesidade é uma das mais sérias consequências da síndrome metabólica humana. Mesmo sendo considerado modelo para a obesidade humana, em gatos essa alteração ainda é controversa. Além disso o estresse oxidativo já foi associado há várias doenças desses animais domésticos e parece ter um importante papel no desenvolvimento das alterações sistêmicas da obesidade. Após revisão sistemática de literatura foi investigada a hipótese de que a hipertensão em gatos naturalmente obesos esteja associada ao estresse oxidativo sistêmico. Em 25 gatos adultos agrupados de acordo com o escore de condição corporal (ECC), controle (ECC 5) e obeso (ECC 7, 8 ou 9) foram comparados e associados parâmetros bioquímicos, hematológicos, antropométricos, a pressão arterial sistólica e marcadores sistêmicos de estresse oxidativo. Embora não tenha ocorrido associação do estresse oxidativo sistêmico e hipertensão arterial, houve uma maior frequência de pré-hipertensão (38%) em gatos obesos e correlação do índice de estresse oxidativo com a circunferência abdominal (r=0,518 P=0,0113). Esses resultados reforçam a necessidade de monitoramento clínico, controle da pressão arterial e estresse oxidativo de gatos obesos para que não ocorram complicações relacionadas a essas alterações.
The fundamental cause of obesity is an energy imbalance between calories consumed and calories expended due the intake of energy-dense foods and physical inactivity. Obesity-related hypertension is one of the most serious consequences of the human metabolic syndrome, this change is still controversial despite cats being considered a model for human obesity. In addition, oxidative stress has already been associated with several diseases of these domestic animals and seems to have an important role in the development of systemic obesity changes. After a systematic review, we investigated the hypothesis that obesity-related hypertension occurs in naturally obese cats and is associated with systemic oxidative stress. In 25 adult cats grouped according to body condition score (BCS), control (BCS 5) and obese (BCS 7, 8 or 9) were evaluated biochemical, hematological, anthropometric, systolic blood pressure and oxidative stress markers. Although there was no association between oxidative stress and hypertension, there was a higher frequency of prehypertension (38%) in obese cats and a correlation between oxidative stress index and waist circumference (r=0.518 P=0.0113). These results reinforce the need for clinical monitoring and control of blood pressure and oxidative stress in obese cats so that complications related to these changes do not occur.
The fundamental cause of obesity is an energy imbalance between calories consumed and calories expended due the intake of energy-dense foods and physical inactivity. Obesity-related hypertension is one of the most serious consequences of the human metabolic syndrome, this change is still controversial despite cats being considered a model for human obesity. In addition, oxidative stress has already been associated with several diseases of these domestic animals and seems to have an important role in the development of systemic obesity changes. After a systematic review, we investigated the hypothesis that obesity-related hypertension occurs in naturally obese cats and is associated with systemic oxidative stress. In 25 adult cats grouped according to body condition score (BCS), control (BCS 5) and obese (BCS 7, 8 or 9) were evaluated biochemical, hematological, anthropometric, systolic blood pressure and oxidative stress markers. Although there was no association between oxidative stress and hypertension, there was a higher frequency of prehypertension (38%) in obese cats and a correlation between oxidative stress index and waist circumference (r=0.518 P=0.0113). These results reinforce the need for clinical monitoring and control of blood pressure and oxidative stress in obese cats so that complications related to these changes do not occur.
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Palavras-chave
Obesidade, Pressão arterial, Antioxidantes, Peroxidação de lipídeos, Obesity, Blood pressure, Antioxidants, Lipid peroxidation