Immunophenotypical and pathological changes in dogs experimentally infected with Ehrlichia canis
Nenhuma Miniatura disponível
Data
2022-01-01
Autores
Castro, Márcio Botelho de
Szabó, Matias Pablo Juan
Aquino, Lucia Padilha Cury Thomaz de
Dagnoni, Ana Silvia
Alessi, Antonio Carlos [UNESP]
Costa, Mirela Tinucci [UNESP]
Nakaghi, Andréa Cristina Higa
Santi, Mariele De [UNESP]
Calchi, Ana Claúdia [UNESP]
André, Marcos Rogério [UNESP]
Título da Revista
ISSN da Revista
Título de Volume
Editor
Resumo
Canine monocytic ehrlichiosis (CME) is one of the most important tick-borne diseases worldwide, with multisystemic presentations. Immune dysregulation has been proposed as the primary mechanism involved in its pathogenesis and in tissue injury in dogs with CME. Experimental infection of German Shepherd dogs in the present study demonstrated that CME caused marked pathological changes in their lymph nodes and spleen, and also gave rise to mononuclear infiltration in organs and tissues. Immunophenotyping of cells in lymph nodes, spleen and injured tissues highlighted differences in lymphocyte subsets, local expression of immunoglobulin subclasses and MHCII molecules between infected and control dogs. These findings suggest that the immunophenotypic and immunopathological changes in dogs with acute experimental CME are related to Th1 bias and compartmentalized immune response.
Descrição
Palavras-chave
canine, immunity, infection, Monocytic ehrlichiosis, tick-borne disease
Como citar
Revista Brasileira de Parasitologia Veterinaria, v. 31, n. 2, 2022.