In vivo antifungal activity and biocompatibility of Cryptocarya moschata
Nenhuma Miniatura disponível
Data
2022-09-01
Autores
de Oliveira Zoccolotti, Jacqueline [UNESP]
Cavalheiro, Alberto José [UNESP]
Tasso, Camilla Olga [UNESP]
de Oliveira, Caroline Correa [UNESP]
Ribas, Beatriz Ribeiro [UNESP]
Ferrisse, Túlio Morandin [UNESP]
de Souza Costa, Carlos Alberto [UNESP]
Jorge, Janaina Habib [UNESP]
Título da Revista
ISSN da Revista
Título de Volume
Editor
Resumo
The objective of this study was evaluate, in vivo model, the antifungal activity of Cryptocarya moschata extract against Candida albicans and its biocompatibility. The animals (N = 50) were divided into groups (n = 5): CI/CG: candidiasis was induced and treated with C. moschata extract (0.045 g/mL); CI/NG: candidiasis was induced and treated with nystatin; CI/NT: candidiasis was induced and no treated; CI/CG-2: candidiasis was induced and treated with C. moschata extract (0.045 g/mL), reapplied after 24 h; CI/NG-2: candidiasis was induced and treated with nystatin, reapplied after 24 h; NCI/NT: candidiasis was not induced and no treated; NCI/CG: candidiasis was not induced and treated with C. moschata extract (0.045 g/mL); NCI/NG: candidiasis was not induced treated with nystatin; NCI/CG-2: candidiasis was not induced and treated with C. moschata extract (0.045 g/mL), reapplied after 24 h; NCI/NG-2: candidiasis was not induced and treated with nystatin, reapplied after 24 h. The fungi present in the lingual dorsum of mice were collected and analyzed by the count of colony-forming units. In addition, histological analysis was performed. Histologically, there was no cell damage in the mice's tongue, and there was a decrease in Candida biofilm, similar to the use of nystatin. It was concluded that the C. moschata extract was effective against C. albicans and was biocompatible.
Descrição
Palavras-chave
Antifungal, Biocompatibility, Candidiasis, Medicinal plant
Como citar
Archives of Microbiology, v. 204, n. 9, 2022.