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dc.contributor.authorTeixeira, MFS
dc.contributor.authorBergamini, M. E.
dc.contributor.authorMarques, CMP
dc.contributor.authorBocchi, N.
dc.identifier.citationTalanta. Amsterdam: Elsevier B.V., v. 63, n. 4, p. 1083-1088, 2004.
dc.description.abstractThe L-dopa is the immediate precursor of the neurotransmitter dopamine. Unlike dopamine, L-dopa easily enters the central nervous system and is used in the treatment of Parkinson's disease. A sensitive and selective method is presented for the voltammetric determination of L-dopa in pharmaceutical formulations using a carbon paste electrode modified with trinuclear ruthenium ammine complex [(NH3)(5)Ru-III-O-Ru-IV(NH3)(4)-O-Ru-III(NH3)(5)](6+) (Ru-red) incorporated in NaY zeolite. The parameters which influence on the electrode response (paste composition, potential scan rate, pH and interference) were also investigated. The optimum conditions were found to an electrode composition (m/m) of 25% zeolite containing 6.7% Ru, 50% graphite and 25% mineral oil in acetate buffer at pH 4.8. Voltammetric peak currents showed a linear response for L-dopa concentration in the range between 1.2 x 10(-4) and 1.0 x 10(-2) Mol l(-1) (r = 0.9988) with a detection limit of 8.5 x 10(-5) mol l(-1). The variation coefficient for a 1.0 x 10(-3) mol l(-1) L-dopa (n = 10) was 5.5%. The results obtained for L-dopa in pharmaceutical formulations (tablet) was in agreement with compared official method. In conclusion, this study has illustrated that the proposed electrode modified with Ru-red incorporated zeolite is suitable valuable for selective measurements of L-dopa. (C) 2004 Elsevier B.V. All rights reserved.en
dc.publisherElsevier B.V.
dc.sourceWeb of Science
dc.subjectmodified carbon pastept
dc.subjectRu-red/zeolite Ypt
dc.subjectvoltammetric determinationpt
dc.subjectpharmaceutical formulationspt
dc.titleVoltammetric determination of L-dopa using an electrode modified with trinuclear ruthenium ammine complex (Ru-red) supported on Y-type zeoliteen
dcterms.rightsHolderElsevier B.V.
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade Federal de São Carlos (UFSCar)
dc.description.affiliationUNESP, Unidade Sao Vicente, BR-11330900 Sao Vicente, SP, Brazil
dc.description.affiliationUniv Fed Sao Carlos, Dept Quim, Sao Carlos, SP, Brazil
dc.description.affiliationUnespUNESP, Unidade Sao Vicente, BR-11330900 Sao Vicente, SP, Brazil
dc.rights.accessRightsAcesso restrito
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, São Vicentept[4][1]
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