Sequential injection analysis system with spectrophotometric detection for determination of norfloxacin and ciprofloxacin in pharmaceutical formulations
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Data
2011-01-01
Autores
Rufino, José Luiz [UNESP]
Pezza, Helena Redigolo [UNESP]
Pezza, Leonardo [UNESP]
Pinto, Paula C. A. G.
Saraiva, M. Lúcia M. F. S.
Lima, José L. F. C.
Título da Revista
ISSN da Revista
Título de Volume
Editor
Sociedade Brasileira de Química
Resumo
This work proposes a sequential injection analysis (SIA) system for the spectrophotometric determination of norfloxacin (NOR) and ciprofloxacin (CIP) in pharmaceutical formulations. The methodology was based on the reaction of these drugs with p-(dimethylamino)cinnamaldehyde in micellar medium, producing orange colored products (λmax = 495 nm). Beer´s law was obeyed in the concentration range from 2.75x10-5 to 3.44x10-4 mol L-1 and 3.26x10-5 to 3.54x10-4 mol L-1 for NOR and CIP, respectively and sampling rate was 25 h-1. Commercial samples were analyzed and results obtained through the proposed method were in good agreement with those obtained using the reference procedure for a 95% confidence level.
Descrição
Palavras-chave
sequential injection analysis, spectrophotometry, pharmaceutical formulations
Como citar
Química Nova. Sociedade Brasileira de Química, v. 34, n. 2, p. 256-261, 2011.