Caracterização do complexo de inclusão ropivacaína: β-ciclodextrina
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Characterization of the inclusion complex ropivacaine: β-cyclodextrinAuthor
Date
2007-10-01Type
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Characteriza of the inclusion complex ropivacaine: β-cyclodextrin. Ropivacaine (RVC) is a widely used local anesthetic. The complexation of RVC with β-cyclodextrin (β-CD) is of great interest for the development of more efficient local anesthetic formulations. The present work focuses on the characterization of the RVC:β-CD complex by nuclear magnetic resonance (NMR). The stoichiometry of the complex is 1:2 RVC:β-CD. DOSY-NMR shows that the association constant is 55.5 M-1. Longitudinal relaxation time results show that RVC changes its mobility in the presence of β-CD. This study is focused on the physicochemical characterization of inclusion complexes that are potentials options for pain treatment.
How to cite this document
Fraceto, Leonardo Fernandes et al. Caracterização do complexo de inclusão ropivacaína: β-ciclodextrina. Química Nova. Sociedade Brasileira de Química, v. 30, n. 5, p. 1203-1207, 2007. Available at: <http://hdl.handle.net/11449/27605>.
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