Antiophidic Solanidane Steroidal Alkaloids from Solanum campaniforme
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2011-10-01
Autores
Torres, Maria Conceicao M.
Pinto, Francisco das Chagas L.
Braz-Filho, Raimundo
Silveira, Edilberto R.
Pessoa, Otilia Deusdenia L.
Jorge, Roberta Jeane Bezerra
Ximenes, Rafael Matos
Azul Monteiro, Helena Serra
Azul Monteiro Evangelista, Janaina Serra
Diz-Filho, Eduardo B. S.
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Amer Chemical Soc
Resumo
Three new solanidane alkaloids bearing a 22,23-epoxy ring (1-3) and four known compounds were isolated from leaves of Solanum campaniforme. The structures were determined using spectroscopic techniques, including ID and 2D NMR, and HRESIMS experiments. The antiophidic activity of the alkaloids was tested against Bothrops pauloensis venom. Compounds 1-3 completely inhibited myotoxicity without inhibiting phospholipase A(2) activity of the venom, while hemorrhage and skin necrosis were significantly reduced in the presence of alkaloids 1 and 2.
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Journal of Natural Products. Washington: Amer Chemical Soc, v. 74, n. 10, p. 2168-2173, 2011.