Differential pulse polarographic determination of ceftazidime in urine samples with and without prior extraction
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Data
1997-09-30
Autores
Ferreira, V. S.
Zanoni, Maria Valnice Boldrin [UNESP]
Furlan, Maysa [UNESP]
Fogg, A. G.
Título da Revista
ISSN da Revista
Título de Volume
Editor
Elsevier B.V.
Resumo
Ceftazidime shows two main polarographic reduction peaks at pH 4.0, that at -0.45 V owing to reduction of the C=N bond in the methylethoxyimino group and that at -1.00 V owing to the reductive elimination of pyridine: the first peak is particularly suitable for the determination of ceftazidime. Ceftazidime can also be determined indirectly using the tensammetric peak at -0.60 V (in Britton-Robinson buffer pH 9.5) of pyridine liberated on hydrolysis. Ceftazidime can be determined in urine using the direct method only after Cls solid phase extraction, but it can be determined directly in the urine by hydrolysing it and using the pyridine peak. (C) 1997 Elsevier B.V. B.V.
Descrição
Palavras-chave
polarography, ceftazidime, solid-phase extraction, urine analysis, bidimensional NMR
Como citar
Analytica Chimica Acta. Amsterdam: Elsevier B.V., v. 351, n. 1-3, p. 105-114, 1997.