Aromatic compounds produced by Periconia atropurpurea, an endophytic fungus associated with Xylopia aromatica
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Data
2006-12-01
Autores
Teles, Helder Lopes
Sordi, Renata
Silva, Geraldo Humberto
Castro-Gamboa, Ian
Bolzani, Vanderlan da Silva [UNESP]
Pfenning, Ludwig Heinrich
de Abreu, Lucas Magalhaes
Costa-Neto, Claudio Miguel
Marx Young, Maria Claudia
Araújo, Angela Regina [UNESP]
Título da Revista
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Título de Volume
Editor
Elsevier B.V.
Resumo
6,8-Dimethoxy-3-(2'-oxo-propyl)-coumarin (1) and 2,4-dihydroxy-6-[(1'E,3'E)-penta-1', 3'-dienyl]-benzaldehyde (2), in addition to the known compound periconicin B (3), were isolated from the ethyl acetate extract of Periconia atropurpurea, an endophytic fungus obtained from the leaves of Xylopia aromatica, a native plant of the Brazilian Cerrado. Their chemical structures were assigned based on analyses of MS, 1D and 2D-NMR spectroscopic experiments. Biological analyses were performed using two mammalian cell lines, human cervix carcinoma (HeLa) and Chinese hamster ovary (CHO). The results showed that compound I had no effect when compared to the control group, which was treated with the vehicle (DMSO). Compound 2 was able to induce a slight increase in cell proliferation of HeLa (37% of increase) and CHO (38% of increase) cell lines. Analysis of compound 3 showed that it has potent cytotoxic activity against both cell lines, with an IC50 of 8.0 mu M. Biological analyses using the phytopathogenic fungi Cladosporium sphaerospermum and C. cladosporioides revealed that also 2 showed potent antifungal activity compared to nystatin. (c) 2006 Elsevier Ltd. All rights reserved.
Descrição
Palavras-chave
Periconia atropurpurea, endophytic fungi, coumarin, benzaldehyde, antifungal, cell proliferation
Como citar
Phytochemistry. Oxford: Pergamon-Elsevier B.V., v. 67, n. 24, p. 2686-2690, 2006.