Clinical outcome in chronic myeloid leukemia after allogeneic hematopoietic stem cell transplantation: The experience of the Bone Marrow Transplantation Unit of FUNFARME/BRAZIL using FISH
Data de publicação2008-07-30
Direito de acesso
MetadadosExibir registro completo
Investigation of the efficacy of allogeneic hematopoietic stem cell transplantation (allo-HSCT) in chronic myeloid leukemia patients is essential to predict prognosis and survival. In 20 patients treated at the Bone Marrow Transplantation Unit of São José do Rio Preto (São Paulo, Brazil), we used fluorescence in situ hybridization (FISH) to investigate the frequency of cells with BCR/ABL rearrangement at diagnosis and at distinct intervals after allo-HSCT until complete cytogenetic remission (CCR). We investigated the disease-free survival, overall survival in 3 years and transplant-related mortality rates, too. Bone marrow samples were collected at 1, 2, 3, 4, 6, 12, and 24 months after transplantation and additional intervals as necessary. Success rate of the FISH analyses was 100%. CCR was achieved in 75% of the patients, within on average of 3.9 months; 45% patients showed CCR within 60 days after HSCT. After 3 years of the allo-HSCT, overall survival rate was 60%, disease-free survival was 50% and the transplant-related mortality rate was 40%. The study demonstrated that the BCR-ABL FISH assay is useful for follow-up of chronic myeloid leukemia patients after HSCT and that the clinical outcome parameters in our patient cohort were similar to those described for other bone marrow transplantation units. ©FUNPEC-RP.
Como citar este documento
Este item aparece nas seguintes coleções
Exibindo os itens relacionados pelo título, autor e palavra-chave.
Andrade, Luís Gustavo Modelli de ; Abrão, Juliana Maria Gera ; Carvalho, Maria Fernanda Cordeiro (International Urology and Nephrology, 2012) [Artigo]Background Post-transplant anemia is multifactorial and highly prevalent. Some studies have associated anemia with mortality and graft failure. The purpose of this study was to assess whether the presence of anemia at 1 ...
Shibli, Jamil Awad; Marcantonio, Elcio ; Spolidório, Luis Carlos ; Marcantonio Júnior, Elcio (Implant Dentistry, 2005) [Artigo]This patient report presents an unusual onlay bone graft failure following local cocaine application. Three months after the bone grafting procedure performed in the anterior maxilla for bone volume augmentation, the bone ...
Estudo da viabilidade celular comparando os meios de conservação para enxerto ósseo de calota craniana: análise microscópica e imunoistoquímica em ratos Tanaka, Fábio Yoshio (Universidade Estadual Paulista (UNESP), 2005) [Tese de doutorado]O objetivo deste trabalho foi analisar a viabilidade celular comparando os meios de conservação para enxerto ósseo. A preservação de células viáveis em procedimentos de enxerto ósseo é de fundamental importância para que ...