Efeito da lavagem peritoneal com bupivacaína na sobrevida de ratos com peritonite fecal
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2008-09-01
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BACKGROUND AND OBJECTIVES: Based on the knowledge of the anti-inflammatory and anti-bacterial actions of local anesthetics (LA), the objective of this study was to determine the effects of peritoneal lavage with bupivacaine on survival of mice with fecal peritonitis. METHODS: Forty-eight Wistar mice, weighing between 300 and 330 g (311.45 ± 9.67 g), undergoing laparotomy 6 hours after induction of peritonitis were randomly divided in 4 groups: 1 - Control, without treatment (n = 12); 2 - Drying of the abdominal cavity (n = 12); 3 - Lavage with 3 mL NS and posterior drying of the abdominal cavity (n = 12); and 4 - Lavage with 8 mg.kg -1 (± 0.5 mL) of 0.5% bupivacaine added to 2.5 mL of NS followed by drying out of the abdominal cavity (n = 12). Animals that died underwent necropsy and the time of death was recorded. Surviving animals were killed on the 11 th postoperative day and underwent necropsy. RESULTS: Group 1 presented a 100% mortality rate in 52 hours, 100% mortality rate in Group 2 in 126 hours, and Group 3 presented a 50% mortality rate in 50 hours. Animals in Group 4 survived. Survival on the 11 th day was greater in groups 3 and 4 than in Groups 1 and 2 (p < 0.001) and greater in Group 4 than in Group 3 (p < 0.01). CONCLUSIONS: Peritoneal lavage with a solution of bupivacaine diluted in NS was effective in preventing death for 11 days in 100% of animals with fecal peritonitis. © Sociedade Brasileira de Anestesiologia, 2008.
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Anesthetic, local: Bupivacaine, Animals: Mice, Complications, infection: Peritonitis, amikacin, aminoglycoside antibiotic agent, amoxicillin plus clavulanic acid, ampicillin, antibiotic agent, bupivacaine, cefazolin, ceftriaxone, cephalosporin derivative, ciprofloxacin, clindamycin, cotrimoxazole, erythromycin, gatifloxacin, gentamicin, ketamine, levofloxacin, lidocaine, linezolid, local anesthetic agent, nitrofurantoin, norfloxacin, oxacillin, penicillin derivative, quinoline derived antiinfective agent, rifampicin, ropivacaine, sultamicillin, unindexed drug, vancomycin, animal experiment, animal model, antibacterial activity, antibiotic sensitivity, antiinflammatory activity, controlled study, drug effect, feces, Gram negative bacterium, Gram positive bacterium, immune response, laparotomy, mortality, mouse, nonhuman, peritoneal cavity, peritoneum lavage, peritonitis, sepsis, survival rate
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Revista Brasileira de Anestesiologia, v. 58, n. 5, p. 470-479, 2008.