Efeitos da ciclosporina a sobre a função renal de cães da raça Golden Retriever normais ou afetados pela distrofia muscular
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Data
2008-12-01
Autores
Morini, Adriana Caroprezo
Miglino, Maria Angélica
Carvalho, Marileda Bonafim [UNESP]
Martins, Daniele dos Santos
Ambrósio, Carlos Eduardo
Casagrande, Carla Fabiana
Catelli, Alida Abatemarco
Souza, Ana Paula [UNESP]
Luppi, Martha Maria Circhia Pinto
Gaiad, Thaís Peixoto
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Resumo
The muscular dystrophy of Golden Retriever is a degenerative miopaty caused by the absence of dystrophy and it is genetically homologue of the Duchenne muscular dystrophy in humans, so, these dogs are considerably experimental models for studies on cellular therapy. Their successful depends of the adequate immunosuppression. Cyclosporin A is indicated for that and the monitoring of blood concentration and adverse effects are essential to viabilise the therapy. It was studied GRMD dogs, and normal dogs from the same breed, submitted for therapy with CsA, associated, on GRMD, of cell transplantation. It was evaluated the possible effects of the drug on renal functions. It has been considerate the clinic manifestations, urinalisis, testis of glomerular function and blood concentrations of urea, cretinine, sodium and potassium. In our results we found a discrete increase of blood urea on booth groups; increased levels of urine's cylinders and protein and also increase of urinary density on GRMD group. CsA therapy could make acute lesions on renal tubules, especially on GRMD. These dogs also have different reactions than normal dogs on relation of ions homeostasis and renal function. However, earlier diagnosis and adequate treatment could prevent the development of renal diseases.
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Palavras-chave
Immunosuppression, Nefrototoxicity, Canis familiaris
Como citar
Brazilian Journal of Veterinary Research and Animal Science, v. 45, n. 5, p. 371-378, 2008.