Modulation of insulin secretion by physical training during recovery from protein malnutrition in rats
MetadataShow full item record
Objective: The purpose of the present study was to examine insulin secretion in rats submitted to protein restriction and nutritional recovery associated or not to physical training. Methods: The experiment was designed in two sets of five weeks each. In the first set the rats were fed a nonnal-protein diet(17%-control group) or a low-protein diet (6%-malnourished group) for five weeks. After this, all animals were fed the 17% protein diet and separated into four groups: sedentary control(SC); trained eontrol(TC); sedentary recovered(SR) and trained recovered(TR). TC and TR rats performed swimming exercise. Results: The results indicated efficiency of the 6% protein diet in producing signs of malnutrition, as reduction in body weight gain and serum albumin levels, as well as liver fat. Serum insulin in the fed state and insulin secretion by isolated pancreatic islets in response to glucose were Keduced,but peripheral sensitivity to insulin was increased and glucose tolerance was not changed in the protein deficient rats, indicating adaptation to malnutrition. Diet protocol for nutritional recovery was efficient in repairing body weight gain, serum albumin and liver fat levels of the previously malnourished rats. Glucose induced insulin release by pancreatic islets remained low after nutritional recovery. Insulin secretion by the islets isolated from rats submitted to exercise training during nutritional recovery was improved when compared with the sedentary animals. Conclusion: This indicates that exercise training may be useful in the treatment of protein calorie malnutrition, concerning to glucose induced insulip secretion.
How to cite this document
Showing items related by title, author, creator and subject.
Low ethanol consumption induces enhancement of insulin sensitivity in liver of normal rats Furuya, Daniela Tomie; Binsack, Ralf; Onishi, Mary Emy; Seraphim, Patricia Monteiro; Machado, Ubiratan Fabres (Life Sciences, 2005) [Artigo]Moderate amounts of alcohol intake have been reported to have a protective effect on the cardiovascular system and this may involve enhanced insulin sensitivity. We established an animal model of increased insulin sensitivity ...
Protein deficiency and nutritional recovery modulate insulin secretion and the early steps of insulin action in rats Latorraca, Márcia Q.; Reis, Marise A. B.; Carneiro, Everardo M. ; Mello, Maria A. R. ; Velloso, Licio A.; Saad, Mario J. A.; Boschero, A. Carlos (Journal of Nutrition, 1998) [Artigo]Maternal malnutrition was shown to affect early growth and leads to permanent alterations in insulin secretion and sensitivity of offspring. In addition, epidemiological studies showed an association between low birth ...
Pancreatic β-cell defects in women at risk of type 2 diabetes Pimenta, W. P. ; Rudge, Marilza Vieira Cunha ; Aragon, F. F. ; Padovani, Carlos Roberto (Diabetes Research and Clinical Practice, 2004) [Artigo]We evaluated insulin release and insulin sensitivity in women with basal and/or postprandial hyperglycemia but normal oral glucose tolerance test (OGTT) in previous pregnancy (GHG). These women were individually matched ...