RSS 1.0Artigos - Análises Clínicas - FCFAR
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Serodiagnosis
Mendes-Giannini, Maria José S.
; ; (Paracoccidioidomycosis, 2018) [Capítulo de livro]
Serological methods are of considerable value in paracoccidioidomycosis. Counter-immunoelectrophoresis, otherwise known as electrosyneresis or immunoelectroosmophoresis, has been frequently applied for the immunodiagnosis ... -
Recent advances in the discovery of small molecules targeting glioblastoma
Fernandes, Guilherme Felipe dos Santos; Fernandes, Barbara Colatto ; Valente, Valeria ; dos Santos, Jean Leandro (European Journal of Medicinal Chemistry, 2019) [Resenha]
Glioblastoma (GBM) is one of the most common central nervous system cancers. It is characterized as a fast-growing tumor that arises from multiple cell types with neural stem-cell-like properties. Additionally, GBM tumors ... -
The lncRNA RMEL3 protects immortalized cells from serum withdrawal-induced growth arrest and promotes melanoma cell proliferation and tumor growth
; ; ; ; ; Valente, Valeria; ; ; (Pigment Cell and Melanoma Research, 2018) [Artigo]
RMEL3 is a recently identified lncRNA associated with BRAFV600E mutation and melanoma cell survival. Here, we demonstrate strong and moderate RMEL3 upregulation in BRAF and NRAS mutant melanoma cells, respectively, compared ... -
Applications of invertebrate animal models to dimorphic fungal infections
Singulani, Junya L.; Scorzoni, Liliana ; de Oliveira, Haroldo C. ; Marcos, Caroline M. ; Assato, Patricia A. ; Fusco-Almeida, Ana Marisa ; Mendes-Giannini, Maria José S. (Journal of Fungi, 2018) [Resenha]
Dimorphic fungi can be found in the yeast form during infection and as hyphae in the environment and are responsible for a large number of infections worldwide. Invertebrate animals have been shown to be convenient models ... -
Transcriptional profile of a bioethanol production contaminant Candida tropicalis
Lourencetti, Natália Manuela Strohmayer; Wolf, Ivan Rodrigo ; Lacerda, Maria Priscila Franco ; Valente, Guilherme Targino ; Zanelli, Cleslei Fernando ; Santoni, Mariana Marchi ; Mendes-Giannini, Maria José Soares ; ; Fusco-Almeida, Ana Marisa (AMB Express, 2018) [Artigo]
The fermentation process is widely used in the industry for bioethanol production. Even though it is widely used, microbial contamination is unpredictable and difficult to control. The problem of reduced productivity is ... -
Influence of eugenia uniflora extract on adhesion to human buccal epithelial cells, biofilm formation, and cell surface hydrophobicity of candida spp. from the oral cavity of kidney transplant recipients
; ; ; ; ; ; Pires, Regina H.; Almeida, Ana Marisa Fusco ; Mendes-Giannini, Maria Jos S. ; (Molecules, 2018) [Artigo]
This study evaluated the influence of the extract of Eugenia uniflora in adhesion to human buccal epithelial cells (HBEC) biofilm formation and cell surface hydrophobicity (CSH) of Candida spp. isolated from the oral cavity ... -
Fungal biofilms: Formation, resistance and pathogenicity
De Cássia Orlandi Sardi, Janaina; De Souza Pitangui, Nayla ; Gullo, Fernanda Patrícia ; Fusco-Almeida, Ana Marisa ; Mendes-Giannini, Maria Jose Soares (Medical Mycology: Current Trends and Future Prospects, 2015) [Capítulo de livro]
Biofilm formation has been detected quite early in the fossil record (~3.25 billion years ago) and is common throughout a diverse range of organisms in both the Archaea and bacteria lineages, including the ‘living fossils’ ... -
Transcriptomic crosstalk between fungal invasive pathogens and their host cells: Opportunities and challenges for next-generation sequencing methods
; ; Fusco-Almeida, Ana Marisa; Mendes-Giannini, Maria José ; (Journal of Fungi, 2016) [Resenha]
Fungal invasive infections are an increasing health problem. The intrinsic complexity of pathogenic fungi and the unmet clinical need for new and more effective treatments requires a detailed knowledge of the infection ... -
Paracoccidioides brasiliensis 14-3-3 protein is important for virulence in a murine model
Marcos, Caroline Maria; de Oliveira, Haroldo Cesar ; Assato, Patricia Akemi ; de Andrade, Cleverton Roberto ; Fusco-Almeida, Ana Marisa ; Mendes-Giannini, Maria José Soares (Medical mycology, 2019) [Artigo]
The Paracoccidioides brasiliensis strain downregulated the expression of adhesin Pb14-3-3 (Pb14-3-3 aRNA) was evaluated in a murine model of paracoccidioidomycosis (PCM). Pb14-3-3 aRNA displays attenuated virulence and ... -
Study of mastoparan analog peptides against Candida albicans and safety in zebrafish embryos (Danio rerio)
Galeane, Mariana C.; Gomes, Paulo C. ; L Singulani, Junya de ; de Souza, Bibiana M. ; Palma, Mario S. ; Mendes-Giannini, Maria Js ; Almeida, Ana Mf (Future microbiology, 2019) [Artigo]
Aim: In this work, mastoparan analog peptides from wasp venom were tested against Candida albicans and safety assays were performed using cell culture and model zebrafish. Materials & methods: Minimal inhibitory concentration ... -
Fast removal of Candida parapsilosis from hemodialysis dialysate using ultraviolet or visible light at nanoporous W/WO3 electrodes
Souza, Barbara A.; Perini, Joao A. ; Giannini, Maria José S.M. ; Zanoni, Maria Valnice Boldrin (Journal of Environmental Chemical Engineering, 2019) [Artigo]
The quality of the water used in a hemodialysis process is critical, and several cases of contamination by C. parapsilosis have been reported in the literature. In addition, it is causing many deaths. The present work ... -
Prophylactic and therapeutic vaccines against sporotrichosis. Feasibility and prospects
Téllez-Martínez, Damiana; Batista-Duharte, Alexander ; Portuondo, Deivys Leandro ; Carlos, Iracilda Zeppone (Microbes and Infection, 2019) [Artigo]
Sporotrichosis is an emergent subcutaneous mycosis of humans and some animals caused by dimorphic fungi of the genus Sporothrix. The disease occurs worldwide but is endemic or hyperendemic in tropical and subtropical areas. ... -
Cryptococcal titan cells: When yeast cells are all grown up
; de Oliveira, Hc; ; (Current Topics in Microbiology and Immunology, 2019) [Capítulo de livro]
Cryptococcus neoformans is a human pathogenic yeast that causes hundreds of thousands of deaths worldwide among susceptible individuals, in particular, HIV+ patients. This yeast has developed several adaptation mechanisms ... -
Curcumin combined with metformin decreases glycemia and dyslipidemia, and increases paraoxonase activity in diabetic rats
Roxo, Daniela Fernandes; Arcaro, Carlos Alberto ; Gutierres, Vania Ortega ; Costa, Mariana Campos ; Oliveira, Juliana Oriel ; Lima, Tayra Ferreira Oliveira ; Assis, Renata Pires ; Brunetti, Iguatemy Lourenço ; Baviera, Amanda Martins (Diabetology and Metabolic Syndrome, 2019) [Artigo]
Background: Combination of current antidiabetic agents with natural antioxidants to manage diabetes mellitus and its complications has appeared as an emerging trend. Curcumin, a yellow pigment isolated from Curcuma longa ... -
Identification of Off-Patent Compounds That Present Antifungal Activity against the Emerging Fungal Pathogen Candida auris
De Oliveira, Haroldo Cesar; ; ; ; ; Mendes-Giannini, Maria José Soares ; ; (Frontiers in Cellular and Infection Microbiology, 2019) [Artigo]
Candida auris is an emerging fungal pathogen of great concern among the scientific community because it is causing an increasing number of hospital outbreaks of difficult management worldwide. In addition, isolates from ... -
In vitro methods to determine the antioxidant activity of caffeic acid
Spagnol, Caroline Magnani; Assis, Renata Pires ; Brunetti, Iguatemy Lourenço ; Isaac, Vera Lucia Borges ; Salgado, Hérida Regina Nunes ; Corrêa, Marcos Antonio (Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2019) [Artigo]
Caffeic acid (CA) is a plant metabolite acting as a carcinogenic inhibitor, and exhibits a high antioxidant effect and some antimicrobial activity. Besides, this compound can be useful in the prevention of heart diseases ... -
A recombinant enolase-montanide™ petgel a vaccine promotes a protective th1 immune response against a highly virulent sporothrix schenckii by toluene exposure
Téllez-Martínez, Damiana; Portuondo, Deivys Leandro ; Loesch, Maria Luiza ; Batista-Duharte, Alexander ; Carlos, Iracilda Zeppone (Pharmaceutics, 2019) [Artigo]
The effect of vaccination in fungal strains that suffered changes in their virulence by exposure to environmental contaminants is largely known. Growing reports of resistance to antifungal drugs and the emergence of new ... -
Genotoxicity, cytotoxicity and chemical profile from Inga laurina (Fabaceae)
Falcoski, T. O.R.; Lima, N. M. ; Navegante, G. ; Serafim, R. B. ; Sorbo, J. M. ; Valente, V. ; ; ; Silva, D. H.S. ; Soares, C. P. (Natural Product Research, 2019) [Artigo]
This study aimed to evaluate the cytotoxicity and genotoxicity from Inga laurina leaves extracts and fractions and obtain their chemical profile. The chemical profile of the crude extract from I. laurina leaves and its ... -
N, N′ N″-trisubstituted guanidines: Synthesis, characterization and evaluation of their leishmanicidal activity
do Espírito Santo, Rafael Dias; Velásquez, Ángela María Arenas ; Passianoto, Luana Vitorino Gushiken ; Sepulveda, Alex Arbey Lopera ; da Costa Clementino, Leandro ; Assis, Renata Pires ; Baviera, Amanda Martins ; ; ; et al. (European Journal of Medicinal Chemistry, 2019) [Artigo]
Leishmaniasis is a group of diseases caused by protozoan parasites from the genus Leishmania. There are estimated 1.3 million new cases annually with a mortality of 20,000–30,000 per year, when patients are left untreated. ... -
Curcumin improves the effect of a reduced insulin dose on glycemic control and oxidative stress in streptozotocin-diabetic rats
Gutierres, Vânia Ortega; Assis, Renata Pires ; Arcaro, Carlos Alberto ; Oliveira, Juliana Oriel ; Lima, Tayra Ferreira Oliveira ; ; Costa, Paulo Inácio ; Baviera, Amanda Martins ; Brunetti, Iguatemy Lourenço (Phytotherapy Research, 2019) [Artigo]
Insulin with natural antioxidants is emerging as a combination treatment for diabetes mellitus that attempts to exert effective glycemic control without adverse effects. The present study aimed to investigate the additive ...