RSS 1.0Artigos - Análises Clínicas - FCFAR
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Discovery of phenylsulfonylfuroxan derivatives as gamma globin inducers by histone acetylation
Melo, Thais Regina Ferreira de
; ; Fernandes, Guilherme Felipe Dos Santos ; ; Chelucci, Rafael Consolin ; Barbieri, Karina Pereira ; Coelho, Fernanda ; Capote, Ticiana Sidorenko de Oliveira ; ; Carlos, Iracilda Zeppone et al. (European journal of medicinal chemistry, 2018) [Artigo]
N-oxide derivatives 5(a-b), 8(a-b), and 11(a-c) were designed, synthesized and evaluated in vitro and in vivo as potential drugs that are able to ameliorate sickle cell disease (SCD) symptoms. All of the compounds demonstrated ... -
Potential of the association of dodecyl gallate with nanostructured lipid system as a treatment for paracoccidioidomycosis: In vitro and in vivo efficacy and toxicity
Singulani, Junya de Lacorte; Scorzoni, Liliana ; Lourencetti, Natália Manuela Strohmayer ; Oliveira, Luana Rossi ; Conçolaro, Rosana Silva ; da Silva, Patricia Bento ; Nazaré, Ana Carolina ; Polaquini, Carlos Roberto ; Victorelli, Francesca Damiani ; Chorilli, Marlus et al. (International Journal of Pharmaceutics, 2018) [Artigo]
Paracoccidioidomycosis (PCM) is a systemic mycosis endemic in Latin America, caused by Paracoccidioides spp. A limited number of antifungal agents are available and the search for new compounds has increased. Additionally, ... -
Evaluation of antimicrobial, cytotoxic and chemopreventive activities of carvone and its derivatives
Moro, Isabela Jacob; Gondo, Gabrielle Demmany Gualberto Alexandre ; Pierri, Elaíse Gonçalves ; Pietro, Rosemeire Cristina Linharis Rodrigues ; Soares, Christiane Pienna ; ; dos Santos, André Gonzaga (Brazilian Journal of Pharmaceutical Sciences, 2017) [Artigo]
Considering the reported activity of carvone in the literature, this study aimed to evaluate the antimicrobial, cytotoxic and chemopreventive activities of (+)- and (-)-carvone, (+)- and (-)- hydroxydihydrocarvone and ... -
Activity of 3′-hydroxychalcone against Cryptococcus gattii and toxicity, and efficacy in alternative animal models
Palanco, Ana Cerrejón; Lacorte Singulani, Junya De ; Costa-Orlandi, Caroline Barcelos ; Gullo, Fernanda Patrícia ; Strohmayer Lourencetti, Natália Manuela ; Gomes, Paulo César ; Ayusso, Gabriela Miranda ; Dutra, Luiz Antônio ; Silva Bolzani, Vanderlan Da ; Regasini, Luis Octávio et al. (Future Microbiology, 2017) [Artigo]
Aim: This work aimed to evaluate the activity of 3′-hydroxychalcone against Cryptococcus gattii in planktonic and biofilm forms and their toxicity using alternative animal models. Materials & methods: Minimum inhibitory ... -
Análise do conhecimento sobre as complicações crônicas do diabetes mellitus não tratado pela população frequentadora da 19ª safe na cidade de araraquara, sp
Suto, Marina Midori; Rodrigues, Caroline Delgado ; Da Fonseca, Jéssica Naiara Varonez ; Dourado, Kethelem Naiara Dos Santos ; Pratis, Tainá Silva ; Furlan, Letícia Cristina ; Assad, Matheus Marques Sanchez ; Marin, Marcelo Tadeu ; Baviera, Amanda Martins (Revista de Ciencias Farmaceuticas Basica e Aplicada, 2017) [Artigo]
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Avaliação da pentoxifilina, inibidor não-seletivo de fosfodiesterases, sobre biomarcadores do estresse oxidativo e glicativo em camundongos submetidos à modelo de obesidade e intolerância à glicose
Inácio, Maiara Destro; Da Costa, Mariana De Campos ; De Lima, Tayra Ferreira Oliveira ; Arcaro, Carlos Alberto ; De Paula, Monalisa Freitas ; De Assis, Renata Pires ; Brunetti, Iguatemy Lourenço ; Baviera, Amanda Martins (Revista de Ciencias Farmaceuticas Basica e Aplicada, 2017) [Artigo]
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Endothelial Cell Culture Under Perfusion On A Polyester-Toner Microfluidic Device
; ; ; ; ; ; Carlos, Iracilda Zeppone; (Scientific Reports, 2017) [Artigo]
This study presents an inexpensive and easy way to produce a microfluidic device that mimics a blood vessel, serving as a start point for cell culture under perfusion, cardiovascular research, and toxicological studies. ... -
Efficacy of a binuclear cyclopalladated compound therapy for cutaneous leishmaniasis in the murine model of infection with Leishmania amazonensis and its inhibitory effect on topoisomerase 1B
Velásquez, Angela Maria Arenas; Ribeiro, Willian Campos ; ; ; ; De Assis, Renata Pires ; De Souza, Rodrigo Alves ; ; Passalacqua, Thaís Gaban ; Da Rosa, João Aristeu et al. (Antimicrobial Agents and Chemotherapy, 2017) [Artigo]
Leishmaniasis is a disease found throughout the (sub)tropical parts of the world caused by protozoan parasites of the Leishmania genus. Despite the numerous problems associated with existing treatments, pharmaceutical ... -
Epigenetic therapy with inhibitors of histone methylation suppresses DNA damage signaling and increases glioma cell radiosensitivity
; ; ; ; Valente, Valeria; (Oncotarget, 2017) [Artigo]
Radiation therapy is widely used to treat human malignancies, but many tumor types, including gliomas, exhibit significant radioresistance. Radiation therapy creates DNA double-strand breaks (DSBs), and DSB repair is linked ... -
Photodynamic therapy combined to cisplatin potentiates cell death responses of cervical cancer cells
de Freitas, Laura Marise; ; ; Moreira, Thaís Fernanda ; dos Santos, Cláudia Tavares ; Baviera, Amanda Martins ; Valente, Valeria ; Soares, Christiane Pienna ; Fontana, Carla Raquel (BMC Cancer, 2017) [Artigo]
Background: Photodynamic therapy (PDT) has proven to be a promising alternative to current cancer treatments, especially if combined with conventional approaches. The technique is based on the administration of a non-toxic ... -
Antifungal therapy: New advances in the understanding and treatment of mycosis
Scorzoni, Liliana; de Paula e Silva, Ana C.A. ; Marcos, Caroline M. ; Assato, Patr�cia A. ; de Melo, Wanessa C.M.A. ; de Oliveira, Haroldo C. ; Costa-Orlandi, Caroline B. ; Mendes-Giannini, Maria J.S. ; Fusco-Almeida, Ana M. (Frontiers in Microbiology, 2017) [Resenha]
The high rates of morbidity and mortality caused by fungal infections are associated with the current limited antifungal arsenal and the high toxicity of the compounds. Additionally, identifying novel drug targets is ... -
Peptides derived from a phage display library inhibit adhesion and protect the host against infection by Paracoccidioides brasiliensis and Paracoccidioides lutzii
de Oliveira, Haroldo C.; ; da Silva, Julhiany F. ; Scorzoni, Liliana ; de Paula e Silva, Ana C.A. ; Marcos, Caroline M. ; Assato, Patr�cia A. ; Yamazaki, Daniella S. ; Fusco-Almeida, Ana M. ; et al. (Frontiers in Pharmacology, 2016) [Artigo]
Paracoccidioides brasiliensis and Paracoccidioides lutzii are dimorphic fungi and are the etiological agents of paracoccidioidomycosis (PCM). Adhesion is one of the most important steps in infections with Paracoccidioides ... -
Evaluation of the efficacy of antifungal drugs against Paracoccidioides brasiliensis and Paracoccidioides lutzii in a Galleria mellonella model
de Lacorte Singulani, Junya; Scorzoni, Liliana ; de Paula e Silva, Ana Carolina Alves ; Fusco-Almeida, Ana Marisa ; Mendes-Giannini, Maria José Soares (International Journal of Antimicrobial Agents, 2016) [Artigo]
Paracoccidioides brasiliensis and P. lutzii belong to a group of thermodimorphic fungi and cause paracoccidioidomycosis (PCM), which is a human systemic mycosis endemic in South and Central America. Patients with this ... -
Decreased expression of 14-3-3 in Paracoccidioides brasiliensis confirms its involvement in fungal pathogenesis
Marcos, Caroline Maria; da Silva, Julhiany de Fátima ; de Oliveira, Haroldo Cesar ; Assato, Patrícia Akemi ; Singulani, Junya de Lacorte ; ; ; ; ; Mendes-Giannini, Maria José Soares et al. (Virulence, 2016) [Artigo]
The interaction between the fungal pathogen Paracoccidioides brasiliensis and host cells is usually mediated by specific binding events between adhesins on the fungal surface and receptors on the host extracellular matrix ... -
Candida/Candida biofilms. First description of dual-species Candida albicans/C. rugosa biofilm
; Pires, Regina Helena; ; ; Singulani, Junya de Lacorte ; ; ; Mendes-Giannini, Maria José Soares (Fungal Biology, 2016) [Artigo]
Denture liners have physical properties that favour plaque accumulation and colonization by Candida species, irritating oral tissues and causing denture stomatitis. To isolate and determine the incidence of oral Candida ... -
Therapeutic and prophylactic tools for sporotrichosis: Current strategies and future tendencies
Batista-Duharte, Alexander; ; ; ; Fuentes, Deivys Portuondo ; Carlos, Iracilda Zeppone (Sporotrichosis: New Developments and Future Prospects, 2015) [Capítulo de livro]
Over the past 3 decades, important progress in the therapy of fungal infections has been made. Although several chemotherapeutic agents are relatively effective against the different species of the Sporothrix schenckii ... -
Models of Experimental Sporotrichosis and Immune Response Against Sporothrix schenckii
Carlos, Iracilda Zeppone; Ferreira, Lucas Souza ; Gonçalves, Amanda Costa (Sporotrichosis: New Developments and Future Prospects, 2015) [Capítulo de livro]
Antifungal host responses can vary depending on the site of infection, fungal pathogen, fungal morphotype (yeast versus hyphae), and immune status of the host. Variation in the virulence of individual Sporothrix schenckii ... -
Sporotrichosis: New developments and future prospects
Carlos, Iracilda Zeppone (Sporotrichosis: New Developments and Future Prospects, 2015) [Livro]
The book presents current affairs of Sporotrichosis as emergent disease with emphasis on the potential factors associated with genetic polymorphisms in Sporothrix complex. Constitutive and inducible factors play an essential ... -
Preface
Carlos, Iracilda Zeppone (Sporotrichosis: New Developments and Future Prospects, 2015) [Editorial]
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Functional analysis of Paracoccidioides brasiliensis 14-3-3 adhesin expressed in Saccharomyces cerevisiae Microbe-host interactions and microbial pathogenicity
Assato, Patricia Akemi; Da Silva, Julhiany De Fátima ; De Oliveira, Haroldo Cesar ; Marcos, Caroline Maria ; Rossi, Danuza ; Valentini, Sandro Roberto ; Mendes-Giannini, Maria José Soares ; Zanelli, Cleslei Fernando ; Fusco-Almeida, Ana Marisa (BMC Microbiology, 2015) [Artigo]
Background: 14-3-3 proteins comprise a family of eukaryotic multifunctional proteins involved in several cellular processes. The Pb14-3-3 of Paracoccidioides brasiliensis seems to play an important role in the Paracoccid ...