RSS 1.0Artigos - Análises Clínicas - FCFAR
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Evaluation of the Anti-Histoplasma capsulatum Activity of Indole and Nitrofuran Derivatives and Their Pharmacological Safety in Three-Dimensional Cell Cultures
Vaso, Carolina Orlando
; Bila, Níura Madalena ; ; ; ; Bonatti, Jean Lucas Carvalho ; de Moraes Silva, Rosângela Aparecida ; Gonçalves, Larissa Naiara Carvalho ; ; et al. (Pharmaceutics, 2022) [Artigo]
Histoplasma capsulatum is a fungus that causes histoplasmosis. The increased evolution of microbial resistance and the adverse effects of current antifungals help new drugs to emerge. In this work, fifty-four nitrofurans ... -
Negative terpinen-4-ol modulate potentially malignant and malignant lingual lesions induced by 4-nitroquinoline-1-oxide in rat model
; Sorbo, Juliana Maria; Filho, Carlos Alberto Arcaro ; Sabino, Thaís Fernanda Moreira ; ; Brunetti, Iguatemy Lourenço ; de Andrade, Cleverton Roberto (Naunyn-Schmiedeberg's Archives of Pharmacology, 2022) [Artigo]
Our aim was to verify the modulative TP-4-ol capacity in 4-nitroquinoline-1-oxide induced oral rat cancer. The stereoisomers of TP-4-ol were used against the human tongue squamous cell line and the negative stereoisomer ... -
Metabolic Profiling of Inga Species with Antitumor Activity
Lima, Nerilson M.; ; Marqui, Sara R. ; Falcoski, Thaís de O. R. S. ; Navegante, Geovana ; Soares, Christiane P. ; ; ; ; et al. (Molecules, 2022) [Artigo]
This work evaluated the metabolic profiling of Inga species with antitumor potential. In addition, we described the antigenotoxicity of polyphenols isolated from I. laurina and a proteomic approach using HepG2 cells after ... -
Advanced methylene blue — nanoemulsions for in vitro photodynamic therapy on oral and cervical human carcinoma
do Amaral, Stéphanie R.; Amantino, Camila F. ; De Annunzio, Sarah R. ; de Paula, Ariela V. ; Fontana, Carla R. ; Primo, Fernando L. (Lasers in Medical Science, 2022) [Artigo]
Photodynamic therapy (PDT) is a therapeutic modality with high contributions in the treatment of cancer. This approach is based on photophysical principles, which presents as a less invasive strategy than conventional ... -
Taxifolin and Lucidin as Potential E6 Protein Inhibitors: p53 Function Re-Establishment and Apoptosis Induction in Cervical Cancer Cells
; ; ; ; ; Soares, Christiane P.; ; ; (Cancers, 2022) [Artigo]
Cervical cancer is the fourth leading cause of death in women worldwide, with 99% of cases associated with a human papillomavirus (HPV) infection. Given that HPV prophylactic vaccines do not exert a therapeutic effect in ... -
Solid Dispersions Incorporated into PVP Films for the Controlled Release of Trans-Resveratrol: Development, Physicochemical and In Vitro Characterizations and In Vivo Cutaneous Anti-Inflammatory Evaluation
Riccio, Bruno Vincenzo Fiod; Do Nascimento, André Luiz Carneiro Soares ; Meneguin, Andréia Bagliotti ; Rodero, Camila Fernanda ; Santos, Kaio Pini ; Sábio, Rafael Miguel ; de Annunzio, Sarah Raquel ; Fontana, Carla Raquel ; ; et al. (Pharmaceutics, 2022) [Artigo]
Trans-resveratrol can promote various dermatological effects. However, its high crystallinity decreases its solubility and bioavailability. Therefore, solid dispersions have been developed to promote its amorphization; ... -
Study of Oligonucleotides Access and Distribution in Human Peripheral Blood Mononuclear Cells
; ; ; ; Duharte, Alexander Batista; (International Journal of Molecular Sciences, 2022) [Artigo]
Therapeutic oligonucleotides have achieved great clinical interest since their approval as drug agents by regulatory agencies but their access and distribution in blood cells are not completely known. We evaluated by flow ... -
COVID-19: The question of genetic diversity and therapeutic intervention approaches
(Genetics and Molecular Biology, 2021) [Resenha]Coronavirus disease 2019 (COVID-19), caused by the Severe Acute Respiratory Syndrome Coronavirus type 2 (SARS-CoV-2), is the largest pandemic in modern history with very high infection rates and considerable mortality. The ... -
Vaccines against Infectious Diseases and Cancer
; Soares, Christiane P.; (Vaccines, 2022) [Editorial]
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A Sporothrix spp. enolase derived multi-epitope vaccine confers protective response in BALB/c mice challenged with Sporothrix brasiliensis
Portuondo, Deivys Leandro; Batista-Duharte, Alexander ; ; ; ; Téllez-Martínez, Damiana ; ; ; ; Castilho, Bruna Mateus de et al. (Microbial Pathogenesis, 2022) [Artigo]
Sporotrichosis is a cosmopolitan mycosis caused by pathogenic species of Sporothrix genus, that in Brazil is often acquired by zoonotic transmission involved infected cats with S. brasiliensis. Previous studies showed that ... -
New Insights into the Mechanism of Action of the Cyclopalladated Complex (CP2) in Leishmania: Calcium Dysregulation, Mitochondrial Dysfunction, and Cell Death
(Antimicrobial Agents and Chemotherapy, 2022) [Artigo]The current treatment of leishmaniasis is based on a few drugs that present several drawbacks, such as high toxicity, difficult administration route, and low efficacy. These disadvantages raise the necessity to develop ... -
PIMREG expression level predicts glioblastoma patient survival and affects temozolomide resistance and DNA damage response
; ; ; Valente, Valeria; (Biochimica et Biophysica Acta - Molecular Basis of Disease, 2022) [Artigo]
PIMREG expression strongly correlates with cellular proliferation in both malignant and normal cells. Throughout embryo development, PIMREG expression is prominent in the central nervous system. Recent studies have described ... -
Synthesis and Evaluation of the Antifungal and Toxicological Activity of Nitrofuran Derivatives
Vaso, Carolina Orlando; ; Bila, Níura Madalena ; ; ; Mendes-Giannini, Maria José Soares ; ; ; Costa-Orlandi, Caroline Barcelos ; Fusco-Almeida, Ana Marisa et al. (Pharmaceutics, 2022) [Artigo]
Fungal diseases affect more than 1 billion people worldwide. The constant global changes, the advent of new pandemics, and chronic diseases favor the diffusion of fungal pathogens such as Candida, Cryptococcus, Aspergillus, ... -
Antifungal activity and toxicity of an octyl gallate-loaded nanostructured lipid system on cells and nonmammalian animals
Singulani, Junya L; Scorzoni, Liliana ; Da Silva, Patricia B ; Nazaré, Ana C ; Polaquini, Carlos R ; Baveloni, Franciele G ; Chorilli, Marlus ; Regasini, Luis O ; Fusco-Almeida, Ana M ; Mendes-Giannini, Maria J.S. (Future Microbiology, 2022) [Artigo]
Aim: Octyl gallate (OG) loaded into a nanostructured lipid system (NLS) was tested for antifungal activity and in vitro and in vivo toxicity. Methods & Results: The features of NLS-OG were analyzed by dynamic light scattering ... -
Editorial: Pathogenesis of Fungal Biofilms in Different Environmental Conditions and Clinical Outcomes
; ; Mendes-Giannini, Maria José Soares; (Frontiers in Cellular and Infection Microbiology, 2021) [Editorial]
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Design, synthesis and biological evaluation of N-oxide derivatives with potent in vivo antileishmanial activity
da Costa Clementino, Leandro; Fernandes, Guilherme Felipe Santos ; Prokopczyk, Igor Muccilo ; Laurindo, Wilquer Castro ; ; Motta, Bruno Pereira ; Baviera, Amanda Martins ; ; dos Santos, Jean Leandro ; Graminha, Marcia A.S. (PLoS ONE, 2021) [Artigo]
Leishmaniasis is a neglected disease that affects 12 million people living mainly in developing countries. Herein, 24 new N-oxide-containing compounds were synthesized followed by in vitro and in vivo evaluation of their ... -
Drk1, a dimorphism histidine kinase, contributes to morphology, virulence, and stress adaptation in paracoccidioides brasiliensis
Marcos, Caroline Maria; de Oliveira, Haroldo Cesar ; Assato, Patrícia Akemi ; ; Fusco-Almeida, Ana Marisa ; Mendes-Giannini, Maria José Soares (Journal of Fungi, 2021) [Artigo]
P. brasiliensis is a thermally dimorphic fungus belonging to Paracoccidioides complex, causative of a systemic, endemic mycosis limited to Latin American countries. Signal transduc-tion pathways related to important aspects ... -
Natural Products with Activity against Multidrug-Resistant Tumor Cells
Bernardes de Andrade Carli, Camila; Quilles, Marcela Bassi ; Carlos, Iracilda Zeppone (Fighting Multidrug Resistance with Herbal Extracts, Essential Oils and their Components, 2013) [Capítulo de livro]
Multidrug resistance is the main mechanism by which cancers develop resistance to chemotherapeutic drugs. Consequently, it is also an important factor in the failure of many forms of chemotherapy. This review describes the ... -
Expression signatures of DNA repair genes correlate with survival prognosis of astrocytoma patients
(Tumor Biology, 2017) [Artigo]Astrocytomas are the most common primary brain tumors. They are very resistant to therapies and usually progress rapidly to high-grade lesions. Here, we investigated the potential role of DNA repair genes in astrocytoma ... -
Immunohistochemical expression of p16INK4a and bcl-2 according to HPV type and to the progression of cervical squamous intraepithelial lesions
(Journal of Histochemistry and Cytochemistry, 2005) [Artigo]Inactivation of the cell cycle inhibitor gene p16MTS1 seems to be involved in human papillomavirus (HPV)-related carcinogenesis because E6 and E7 oncoproteins may impair p16INK4a and, indirectly, bcl-2 functions. In this ...