RSS 1.0Artigos - Análises Clínicas - FCFAR
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HJURP knockdown disrupts clonogenic capacity and increases radiation-induced cell death of glioblastoma cells
; ; ; Pienna Soares, Christiane
; ; ; ; ; Valente, Valeria (Cancer Gene Therapy, 2020) [Artigo]
The Holliday Junction-Recognition Protein (HJURP) was reported as overexpressed in several cancers and also strongly correlated with poor prognosis of patients, especially in glioblastoma (GBM), the most common and deadly ... -
Efficacy of photodynamic therapy using TiO2 nanoparticles doped with Zn and hypericin in the treatment of cutaneous Leishmaniasis caused by Leishmania amazonensis
; Arenas Velásquez, Angela Maria; ; de Almeida, Leticia ; Fontana, Carla Raquel ; ; Graminha, Marcia Aparecida Silva (Photodiagnosis and Photodynamic Therapy, 2020) [Artigo]
Since Leishmania parasites exhibit resistance outbreaks to drugs conventionally used in medical treatments, research of new antileishmanial compounds or alternative treatment therapies are essential. A focus of interest ... -
Lycopene improves the metformin effects on glycemic control and decreases biomarkers of glycoxidative stress in diabetic rats
Figueiredo, Ingrid Delbone; Lima, Tayra Ferreira Oliveira ; Inácio, Maiara Destro ; Costa, Mariana Campos ; Assis, Renata Pires ; Brunetti, Iguatemy Lourenço ; Baviera, Amanda Martins (Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, 2020) [Artigo]
Introduction: Oxidative stress and exacerbated generation of advanced glycation end products (AGEs) participate in the onset of diabetic complications. Lycopene is a potent antioxidant; evidence accounts for its ability ... -
Gentamicin encapsulated within a biopolymer for the treatment of Staphylococcus aureus and Escherichia coli infected skin ulcers
Gemeinder, José Lúcio Pádua; Barros, Natan Roberto de ; Pegorin, Giovana Sant’Ana ; Singulani, Junya de Lacorte ; Borges, Felipe Azevedo ; ; Giannini, Maria José Soares Mendes ; Almeida, Ana Marisa Fusco ; ; Herculano, Rondinelli Donizetti (Journal of Biomaterials Science, Polymer Edition, 2020) [Artigo]
Skin wound infection requires carefully long-term treatment with an immense financial burden to healthcare systems worldwide. Various strategies such as drug delivery systems using polymer matrix from natural source have ... -
Transient Foxp3(+) regulatory T-cell depletion enhances protective Th1/Th17 immune response in murine sporotrichosis caused by Sporothrix schenckii
Batista-Duharte, Alexander; Téllez-Martínez, Damiana ; de Andrade, Cleverton Roberto ; Polesi, Marisa Campos ; Portuondo, Deivys Leandro ; Carlos, Iracilda Zeppone (Immunobiology, 2020) [Artigo]
The role of regulatory T cells (Tregs) on protective immunity in fungal infections, is controversial. Sporotrichosis is an emerging and worldwide-distributed subcutaneous mycosis caused by various related thermodimorphic ... -
Pentoxifylline mitigates renal glycoxidative stress in obese mice by inhibiting AGE/RAGE signaling and increasing glyoxalase levels
Inacio, Maiara Destro; Costa, Mariana Campos ; Lima, Tayra Ferreira Oliveira ; Figueiredo, Ingrid Delbone ; Motta, Bruno Pereira ; Spolidorio, Luís Carlos ; Assis, Renata Pires ; Brunetti, Iguatemy Lourenço ; Baviera, Amanda Martins (Life Sciences, 2020) [Artigo]
Aim: The pharmacological properties of pentoxifylline have been re-evaluated, particularly in chronic kidney disease in diabetes, favored by its anti-inflammatory action. Definitive evidences of renal outcomes are lacking, ... -
Biofilm Formation by Histoplasma capsulatum in Different Culture Media and Oxygen Atmospheres
Gonçalves, Larissa Naiara Carvalho; Costa-Orlandi, Caroline Barcelos ; Bila, Níura Madalena ; Vaso, Carolina Orlando ; Da Silva, Rosângela Aparecida Moraes ; Mendes-Giannini, Maria José Soares ; ; Fusco-Almeida, Ana Marisa (Frontiers in Microbiology, 2020) [Artigo]
Histoplasma capsulatum is a dimorphic fungus that causes an important systemic mycosis called histoplasmosis. It is an infectious disease with high prevalence and morbidity that affects the general population. Recently, ... -
Effect of fermented sausages with probiotic Enterococcus faecium CRL 183 on gut microbiota using dynamic colonic model
Roselino, Mariana Nougalli; ; ; Márcia Canaan, Josiane Maria ; ; Rossi, Elizeu Antonio ; ; Umbelino Cavallini, Daniela Cardoso (LWT, 2020) [Artigo]
Considering the importance of nutrition in maintaining health conditions, this study is aimed at evaluating the effect of the consumption of a potentially probiotic sausage, with reduction of curing salts and fat, fermented ... -
Chick embryo chorioallantoic membrane as a suitable in vivo model to evaluate drug delivery systems for cancer treatment: A review
Victorelli, Francesca Damiani; Cardoso, Valéria Maria de Oliveira ; Ferreira, Natália Noronha ; Calixto, Giovana Maria Fioramonti ; Fontana, Carla Raquel ; ; Gremião, Maria Palmira Daflon ; Chorilli, Marlus (European Journal of Pharmaceutics and Biopharmaceutics, 2020) [Artigo]
Cancer represents a significant public health problem. More than 18.1 million people are annually diagnosed with cancer and 9.6 million die mainly due to metastatic disease. Chemotherapy has been one of the main cancer ... -
Incorporation of Nonyl 3,4-Dihydroxybenzoate Into Nanostructured Lipid Systems: Effective Alternative for Maintaining Anti-Dermatophytic and Antibiofilm Activities and Reducing Toxicity at High Concentrations
Costa-Orlandi, Caroline Barcelos; Serafim-Pinto, Aline ; da Silva, Patrícia Bento ; Bila, Níura Madalena ; Bonatti, Jean Lucas de Carvalho ; Scorzoni, Liliana ; Singulani, Junya de Lacorte ; Santos, Claudia Tavares dos ; Nazaré, Ana Carolina ; Chorilli, Marlus et al. (Frontiers in Microbiology, 2020) [Artigo]
Dermatophytosis is the most common mycosis worldwide, affecting approximately 20 to 25% of the population, regardless of gender, race, color, and age. Most antifungal agents used for the treatment of dermatophytosis belong ... -
Curcumin, Alone or in Combination with Aminoguanidine, Increases Antioxidant Defenses and Glycation Product Detoxification in Streptozotocin-Diabetic Rats: A Therapeutic Strategy to Mitigate Glycoxidative Stress
Lima, Tayra Ferreira Oliveira; Costa, Mariana Campos ; Figueiredo, Ingrid Delbone ; Inácio, Maiara Destro ; ; Assis, Renata Pires ; Baviera, Amanda Martins ; Brunetti, Iguatemy Lourenço (Oxidative Medicine and Cellular Longevity, 2020) [Artigo]
Both oxidative stress and the exacerbated generation of advanced glycation end products (AGEs) have crucial roles in the onset and progression of diabetic complications. Curcumin has antioxidant and antidiabetic properties; ... -
Mesenchymal stem cell (MSc) secretome: A possible therapeutic strategy for intensive-care COVID-19 patients
Deffune, Elenice; Prudenciatti, Aruã ; Moroz, Andrei (Medical Hypotheses, 2020) [Carta]
As an emerging global health challenge, COVID-19 requires international knowledge to reach novel possible therapeutic strategies, especially for intensive-care patients. During the early stages of infection, pneumocytes ... -
Antimicrobial activity of RP-1 peptide conjugate with ferrocene group
Costa, Natalia C.S.; Piccoli, Julia P. ; Santos-Filho, Norival A. ; Clementino, Leandro C. ; Fusco-Almeida, Ana M. ; De Annunzio, Sarah R. ; Fontana, Carla R. ; Verga, Juliane B.M. ; Eto, Silas F. ; Pizauro-Junior, João M. et al. (PLoS ONE, 2020) [Artigo]
Parasitic diseases are a neglected and serious problem, especially in underdeveloped countries. Among the major parasitic diseases, Leishmaniasis figures as an urgent challenge due to its high incidence and severity. At ... -
Identification of off-patent drugs that show synergism with amphotericin B or that present antifungal action against Cryptococcus neoformans and Candida spp.
; De Oliveira, Haroldo Cesar; ; ; Soares Mendes-Giannini, Maria José ; ; (Antimicrobial Agents and Chemotherapy, 2020) [Artigo]
Amphotericin B (AmB) is the antifungal with the strongest fungicidal activity, but its use has several limitations, mainly associated with its toxicity. Although some lipidic and liposomal formulations that present reduced ... -
Antifungal activity of 2′-hydroxychalcone loaded in nanoemulsion against Paracoccidioides spp
Medina-Alarcón, Kaila P; Singulani, Junya De L. ; ; Pitangui, Nayla De S. ; ; Dos Santos, Mariana B. ; Ayusso, Gabriela M. ; Regasini, Luis O. ; Soares, Christiane P. ; Chorilli, Marlus et al. (Future Microbiology, 2020) [Artigo]
Aim: This study aimed to evaluate the activity of 2′-hydroxychalcone-loaded in nanoemulsion (NLS + 2′chalc), the cytotoxic effect and toxicity against Paracoccidioides brasiliensis and Paracoccidioides lutzii using a ... -
Progress in the use of antisense oligonucleotides for vaccine improvement
Batista-Duharte, Alexander; ; ; Téllez-Martínez, Damiana ; Carlos, Iracilda Zeppone ; (Biomolecules, 2020) [Resenha]
Antisense oligonucleotides (ASOs) are synthetically prepared short single-stranded deoxynucleotide sequences that have been validated as therapeutic agents and as a valuable tool in molecular driving biology. ASOs can block ... -
DNA repair genes in astrocytoma tumorigenesis, progression and therapy resistance
; ; ; Fontana, Carla Raquel; Valente, Valeria (Genetics and Molecular Biology, 2020) [Resenha]
Glioblastoma (GBM) is the most common and malignant type of primary brain tumor, showing rapid development and resistance to therapies. On average, patients survive 14.6 months after diagnosis and less than 5% survive five ... -
Antifungal Activity, Toxicity, and Membranolytic Action of a Mastoparan Analog Peptide
Singulani, Junya de Lacorte; Galeane, Mariana Cristina ; Ramos, Marina Dorisse ; Gomes, Paulo César ; dos Santos, Claudia Tavares ; de Souza, Bibiana Monson ; Palma, Mario Sergio ; Fusco Almeida, Ana Marisa ; Mendes Giannini, Maria José Soares (Frontiers in Cellular and Infection Microbiology, 2019) [Artigo]
Invasive fungal infections, such as cryptococcosis and paracoccidioidomycosis are associated with significant rates of morbidity and mortality. Cryptococcosis, caused by Cryptococcus neoformans, is distributed worldwide ... -
Trigonelline and curcumin alone, but not in combination, counteract oxidative stress and inflammation and increase glycation product detoxification in the liver and kidney of mice with high-fat diet-induced obesity
Costa, Mariana Campos; Lima, Tayra Ferreira Oliveira ; Arcaro, Carlos Alberto ; Inacio, Maiara Destro ; Batista-Duharte, Alexander ; Carlos, Iracilda Zeppone ; Spolidorio, Luís Carlos ; Assis, Renata Pires ; Brunetti, Iguatemy Lourenço ; Baviera, Amanda Martins (Journal of Nutritional Biochemistry, 2020) [Artigo]
The development of obesity-associated complications is related to various pathogenic events including chronic inflammation, oxidative stress and generation of advanced glycation end products (AGEs). Due to their antioxidant, ... -
Phthalocyanine-loaded nanostructured lipid carriers functionalized with folic acid for photodynamic therapy
; Sato, Mariana Rillo; Boni, Fernanda Isadora ; ; ; de Freitas, Laura Marise ; Fontana, Carla Raquel ; ; ; et al. (Materials Science and Engineering C, 2020) [Artigo]
Breast cancer is a serious public health problem that causes thousands of deaths annually. Chemotherapy continues to play a central role in the management of breast cancer but is associated with extreme off-target toxicity. ...