• New Insights into the Mechanism of Action of the Cyclopalladated Complex (CP2) in Leishmania: Calcium Dysregulation, Mitochondrial Dysfunction, and Cell Death 

  Velásquez, Angela Maria Arenas; Bartlett, Paula; Linares, Irwin Alexander Patino; Passalacqua, Thais G.; Teodoro, Daphne D. L.; Imamura, Kely B.; Virgilio, Stela; Tosi, Luiz R. O.; Leite, Aline de Lima; Buzalaf, Marilia A. R. et al. (Antimicrobial Agents and Chemotherapy, 2022) [Artigo]

  The current treatment of leishmaniasis is based on a few drugs that present several drawbacks, such as high toxicity, difficult administration route, and low efficacy. These disadvantages raise the necessity to develop ...

• PIMREG expression level predicts glioblastoma patient survival and affects temozolomide resistance and DNA damage response 

  Serafim, Rodolfo Bortolozo; Cardoso, Cibele; Arfelli, Vanessa Cristina; Valente, Valeria ; Archangelo, Leticia Fröhlich (Biochimica et Biophysica Acta - Molecular Basis of Disease, 2022) [Artigo]

  PIMREG expression strongly correlates with cellular proliferation in both malignant and normal cells. Throughout embryo development, PIMREG expression is prominent in the central nervous system. Recent studies have described ...

• Synthesis and Evaluation of the Antifungal and Toxicological Activity of Nitrofuran Derivatives 

  Vaso, Carolina Orlando ; Pandolfi, Fabiana; Bila, Níura Madalena ; De Vita, Daniela; Bortolami, Martina; Mendes-Giannini, Maria José Soares ; Tudino, Valeria; Costi, Roberta; Costa-Orlandi, Caroline Barcelos ; Fusco-Almeida, Ana Marisa et al. (Pharmaceutics, 2022) [Artigo]

  Fungal diseases affect more than 1 billion people worldwide. The constant global changes, the advent of new pandemics, and chronic diseases favor the diffusion of fungal pathogens such as Candida, Cryptococcus, Aspergillus, ...

• Antifungal activity and toxicity of an octyl gallate-loaded nanostructured lipid system on cells and nonmammalian animals 

  Singulani, Junya L ; Scorzoni, Liliana ; Da Silva, Patricia B ; Nazaré, Ana C ; Polaquini, Carlos R ; Baveloni, Franciele G ; Chorilli, Marlus ; Regasini, Luis O ; Fusco-Almeida, Ana M ; Mendes-Giannini, Maria J.S. (Future Microbiology, 2022) [Artigo]

  Aim: Octyl gallate (OG) loaded into a nanostructured lipid system (NLS) was tested for antifungal activity and in vitro and in vivo toxicity. Methods & Results: The features of NLS-OG were analyzed by dynamic light scattering ...

• Editorial: Pathogenesis of Fungal Biofilms in Different Environmental Conditions and Clinical Outcomes 

  Pires, Regina Helena; Martinez, Luis R.; Mendes-Giannini, Maria José Soares ; Stoianoff, Maria Aparecida Resende (Frontiers in Cellular and Infection Microbiology, 2021) [Editorial]

• Design, synthesis and biological evaluation of N-oxide derivatives with potent in vivo antileishmanial activity 

  da Costa Clementino, Leandro ; Fernandes, Guilherme Felipe Santos ; Prokopczyk, Igor Muccilo ; Laurindo, Wilquer Castro ; Toyama, Danyelle; Motta, Bruno Pereira ; Baviera, Amanda Martins ; Henrique-Silva, Flávio; dos Santos, Jean Leandro ; Graminha, Marcia A.S. (PLoS ONE, 2021) [Artigo]

  Leishmaniasis is a neglected disease that affects 12 million people living mainly in developing countries. Herein, 24 new N-oxide-containing compounds were synthesized followed by in vitro and in vivo evaluation of their ...

• Drk1, a dimorphism histidine kinase, contributes to morphology, virulence, and stress adaptation in paracoccidioides brasiliensis 

  Marcos, Caroline Maria ; de Oliveira, Haroldo Cesar ; Assato, Patrícia Akemi ; Castelli, Rafael Fernando; Fusco-Almeida, Ana Marisa ; Mendes-Giannini, Maria José Soares (Journal of Fungi, 2021) [Artigo]

  P. brasiliensis is a thermally dimorphic fungus belonging to Paracoccidioides complex, causative of a systemic, endemic mycosis limited to Latin American countries. Signal transduc-tion pathways related to important aspects ...

• Natural Products with Activity against Multidrug-Resistant Tumor Cells 

  Bernardes de Andrade Carli, Camila ; Quilles, Marcela Bassi ; Carlos, Iracilda Zeppone (Fighting Multidrug Resistance with Herbal Extracts, Essential Oils and their Components, 2013) [Capítulo de livro]

  Multidrug resistance is the main mechanism by which cancers develop resistance to chemotherapeutic drugs. Consequently, it is also an important factor in the failure of many forms of chemotherapy. This review describes the ...

• Expression signatures of DNA repair genes correlate with survival prognosis of astrocytoma patients 

  de Sousa, Juliana Ferreira; Torrieri, Raul; Serafim, Rodolfo Bortolozo; Di Cristofaro, Luis Fernando Macedo; Escanfella, Fábio Dalbon; Ribeiro, Rodrigo; Zanette, Dalila Lucíola; Paçó-Larson, Maria Luisa; da Silva, Wilson Araujo; Tirapelli, Daniela Pretti da Cunha et al. (Tumor Biology, 2017) [Artigo]

  Astrocytomas are the most common primary brain tumors. They are very resistant to therapies and usually progress rapidly to high-grade lesions. Here, we investigated the potential role of DNA repair genes in astrocytoma ...

• Immunohistochemical expression of p16INK4a and bcl-2 according to HPV type and to the progression of cervical squamous intraepithelial lesions 

  Guimarães, Márcia C.M.; Gonçalves, Maria Alice G.; Soares, Christiane P.; Bettini, Jussara S.R.; Duarte, Roberta A.; Soares, Edson G. (Journal of Histochemistry and Cytochemistry, 2005) [Artigo]

  Inactivation of the cell cycle inhibitor gene p16MTS1 seems to be involved in human papillomavirus (HPV)-related carcinogenesis because E6 and E7 oncoproteins may impair p16INK4a and, indirectly, bcl-2 functions. In this ...

• Performance of selective and differential media in the primary isolation of yeasts from different biological samples 

  Silva, Jaqueline Otero; Franceschini, Silvio Antônio; Lavrador, Marco Aurélio Sicchiroli; Candido, Regina Célia (Mycopathologia, 2004) [Artigo]

  In view of the increase in yeast infections, especially polymicrobial ones, differential culture media have acquired increasing importance. The present study evaluated the Sabouraud chloramphenicol, Biggy agar, Pagano Levin ...

• Assessment of monocytic component in acute myelomonocytic and monocytic/monoblastic leukemias by a chemiluminescent assay 

  da Fonseca, Luiz M.; Brunetti, Iguatemy L.; Campa, Ana; Catalani, Luiz H.; Calado, Rodrigo T.; Falcão, Roberto Passetto (Hematology Journal, 2003) [Artigo]

  Introduction: Classically, the monocytic component of acute myelomonocytic (FAB-M4) and acute monocytic/monoblastic (FAB-M5) leukemias is demonstrated by nonspecific esterase positivity in cytochemical stainings. We have ...

• Evaluation of argyrophilic nucleolar organizer regions in oral tumor progression 

  Spolidorio, L. C.; Neves, K. A.; Soares, C. P.; Spolidorio, D. M.P.; Basso, M. F.M.; Malavazzi, I.; Almeida, O. P. (Micron, 2002) [Artigo]

  The aim of this study was to compare the presence of nucleolar organizer regions (NORs) in normal oral mucosa, dysplasia and microinvasive carcinoma. All histological specimens were reviewed according to the modified ...

• In vitro and alternative animal models to evaluate the biocompatibility of natural latex-calcium phosphate-based polymer 

  Miranda, Matheus Carlos Romeiro ; Borges, Felipe Azevedo ; Barros, Natan Roberto ; Marques, Marina Paganine ; Galeane, Mariana Cristina ; de Lacorte Singulani, Junya ; Guerra, Nayrim Brizuela; Brasil, Giovana Sant’Ana Pegorin ; Mussagy, Cassamo Ussemane ; Almeida, Ana Marisa Fusco et al. (Journal of Polymers and the Environment, 2022) [Artigo]

  The number of mammalian animals killed for research purposes has increased significantly in recent years. For this reason, several alternative animal models have been widely used. In this study, two phases of calcium ...

• Recovery of β-carotene and astaxanthin from Phaffia rhodozyma biomass using aqueous solutions of cholinium-based ionic liquids 

  Mussagy, Cassamo U.; Farias, Fabiane O.; Bila, Niura M. ; Giannini, Maria J.S.M. ; Pereira, Jorge F.B.; Santos-Ebinuma, Valeria C. ; Pessoa Jr, Adalberto (Separation and Purification Technology, 2022) [Artigo]

  The red yeast Phaffia rhodozyma is a natural source of high-added value carotenoids such as β-carotene and astaxanthin, widely used in the cosmeceutical, chemical, feed/food and pharmaceutical industries. This yeast is ...

• Effect of the technique of photodynamic therapy against the main microorganisms responsible for periodontitis: A systematic review of in-vitro studies 

  Sales, Luciana Solera ; Miranda, Marina Lins ; de Oliveira, Analú Barros ; Ferrisse, Túlio Morandin ; Fontana, Carla Raquel ; Milward, Michael; Brighenti, Fernanda Lourenção (Archives of Oral Biology, 2022) [Resenha]

  Objective: The present study aimed to conduct a systematic review of the literature, to evaluate, in vitro, the effectiveness of the technique of photodynamic therapy against microorganisms associated with periodontal ...

• Stability of Acid Black 210 dye in Tannery Industry Effluent in Aqueous Solution Is Limited and Generates Harmful Subproducts 

  Christovam, Elisa Maria ; Franco, Jefferson Honorio; Zocolo, Guilherme Julião; Fusco Almeida, Ana Marisa ; Marcelino, Monica Yonashiro ; de Oliveira, Danielle Palma; Boldrin Zanoni, Maria Valnice (Frontiers in Environmental Science, 2022) [Artigo]

  The present work investigates the occurrence of the Acid Black 210 (AB210) dye and its subproducts in the tannery industry by analytical techniques. The AB210 is an important dye characterized by three azo groups as a ...

• Antifungal Activity and Biocompatibility of α-AgVO3, α-Ag2WO4, and β-Ag2MoO4 Using a Three-Dimensional Coculture Model of the Oral Mucosa 

  Pimentel, Bruna Natália Alves da Silva ; Marin-Dett, Freddy Humberto ; Assis, Marcelo; Barbugli, Paula Aboud ; Longo, Elson; Vergani, Carlos Eduardo (Frontiers in Bioengineering and Biotechnology, 2022) [Artigo]

  Fungal infections have become a major concern in the medical community, especially those caused by Candida spp. Within this species, Candida albicans stands out for being an opportunistic commensal fungus that can cause ...

• Encapsulating Anti-Parasite Benzimidazole Drugs into Lipid-Coated Calcium Phosphate Nanoparticles to Efficiently Induce Skin Cancer Cell Apoptosis 

  Movahedi, Fatemeh; Gu, Wenyi; Soares, Christiane Pienna ; Xu, Zhi Ping (Frontiers in Nanotechnology, 2021) [Artigo]

  Benzimidazole (BMZ) family of anti-worm drugs has been now repurposed as anti-cancer drugs. However, offering a general reformulation method for these drugs is essential due to their hydrophobicity and low aqueous solubility. ...

• Editorial: Nanotechnology for Precision Cancer Therapy: Advances in Gene Therapy, Immunotherapy, and 3D Bioprinting 

  Sousa, Ângela; Barud, Hernane Da Silva; Xu, Zhi Ping; Soares, Christiane P. (Frontiers in Nanotechnology, 2021) [Editorial]

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