Photodynamic therapy for the treatment of induced mammary tumor in rats
MetadataShow full item record
The objective of this work was to evaluate photodynamic therapy (PDT) by using a hematoporphyrin derivative as a photosensitizer and light-emitting diodes (LEDs) as light source in induced mammary tumors of Sprague-Dawley (SD) rats. Twenty SD rats with mammary tumors induced by DMBA were used. Animals were divided into four groups: control (G1), PDT only (G2), surgical removal of tumor (G3), and submitted to PDT immediately after surgical removal of tumor (G4). Tumors were measured over 6 weeks. Lesions and surgical were LEDs lighted up (200 J/cm2 dose). The light distribution in vivo study used two additional animals without mammary tumors. In the control group, the average growth of tumor diameter was approximately 0.40 cm/week. While for PDT group, a growth of less than 0.15 cm/week was observed, suggesting significant delay in tumor growth. Therefore, only partial irradiation of the tumors occurred with a reduction in development, but without elimination. Animals in G4 had no tumor recurrence during the 12 weeks, after chemical induction, when compared with G3 animals that showed 60 % recurrence rate after 12 weeks of chemical induction. PDT used in the experimental model of mammary tumor as a single therapy was effective in reducing tumor development, so the surgery associated with PDT is a safe and efficient destruction of residual tumor, preventing recurrence of the tumor. © 2012 Springer-Verlag London Ltd.
How to cite this document
Showing items related by title, author, creator and subject.
Zuccari, Debora A. P. C. ; Santana, Aureo E. ; Cury, Patrícia M.; Cordeiro, José Antônio (Veterinary Clinical Pathology, 2004) [Artigo]Background: Canine mammary tumors are challenging for clinicians and pathologists because of complex histologic classification, low specificity of cytologic diagnosis, and unpredictable biological behavior. In histologic ...
Corpa, Marcus V.N.; Serafini, Eduardo P.; Bacchi, Carlos E. (Annals of Diagnostic Pathology, 2004) [Artigo]Endometrial stromal sarcoma is a rare neoplasm of the uterus. Extrauterine locations of this neoplasm, excluding metastases or local extension, are even more unusual and are usually associated with the presence of ...
Desmoplastic small round cell tumor of the kidney mimicking wilms tumor: A case report and review of the literature Da Silva, Rogério Cardoso; Filho, Plínio Medeiros; Chioato, Lucimara; Silva, Tácio R.B.; Ribeiro, Sérgio M. ; Bacchi, Carlos E. (Applied Immunohistochemistry and Molecular Morphology, 2009) [Artigo]Desmoplastic small round cell tumor (DSRCT) is a rare, aggressive, malignant neoplasm usually present with the widespread abdominal serosal involvement and affects mainly adolescents and young adults. When presenting within ...