Organotins: A review of their reproductive toxicity, biochemistry, and environmental fate
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Data
2013-04-01
Autores
Graceli, Jones Bernardes
Sena, Gabriela Cavati
Lopes, Pedro Francisco Iguatemy
Zamprogno, Gabriela Carvalho
da Costa, Mércia Barcellos
Godoi, Ana Flavia Locateli
dos Santos, Dayana Moscardi
Marchi, Mary Rosa Rodrigues de [UNESP]
dos Santos Fernandez, Marcos Antonio
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Resumo
The review purposes are to (1) evaluate the experimental evidence for adverse effects on reproduction and metabolism and (2) identify the current knowledge of analytical procedures, biochemistry and environmental aspects relating to organotins. Organotins are pollutants that are used as biocides in antifouling paints. They produce endocrine-disrupting effects in mollusks, such as imposex. In rodents, organotin exposure induces developmental and reproductive toxicity as well as alteration of metabolic homeostasis through its action as an obesogen. The adverse effects that appear in rodents have raised concerns about organotins' potential health risk to humans in relation to organotin exposure. At present, triorganotin, such as tributyltin, have been demonstrated to produce imposex, and mammalian reproductive and metabolic toxicity. For most mammals, triorganotin exposure predominantly occurs through the ingestion, and this compound can cross the placenta. With these risks in mind, it is important to improve our knowledge of organotins' effects on environmental health. © 2012 Elsevier Inc.
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Biochemistry, Environmental fate, Obesogens, Organotins, Reproductive toxicity, organotin compound, tributyltin, triorganotin derivative, triphenyltin, unclassified drug, analytic method, bioaccumulation, biochemistry, chemical analysis, chemical composition, chemical modification, developmental toxicity, endocrine disease, environmental aspects and related phenomena, female genital system, gonad, health hazard, human, immunotoxicity, impotence, male genital system, metabolic disorder, nonhuman, obesity, reproductive toxicity, Animals, Disinfectants, Endocrine Disruptors, Endocrine System, Energy Metabolism, Environmental Exposure, Female, Humans, Immunotoxins, Infertility, Female, Infertility, Male, Male, Obesity, Organotin Compounds, Trialkyltin Compounds, Mammalia, Mollusca, Rodentia
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Reproductive Toxicology, v. 36, p. 40-52.