RSS 1.0Departamento de Fármacos e Medicamentos
Browse by
Recent Submissions
-
Rethinking Breast Cancer Chemoprevention: Technological Advantages and Enhanced Performance of a Nanoethosomal-Based Hydrogel for Topical Administration of Fenretinide
; ; ; Chorilli, Marlus
; (AAPS PharmSciTech, 2022) [Artigo]
Herein, we developed an ethosomal hydrogel based on three types of ethosomes: simple, mixed (surfactant-based micelles and lipid vesicles) or binary (comprising two type of alcohols). Ethanol injection was employed for ... -
Folic acid-modified curcumin-loaded liposomes for breast cancer therapy
; Dutra, Jessyca Aparecida Paes; Ribeiro, Taís de Cássia ; Carvalho, Gabriela Corrêa ; Sábio, Rafael Miguel ; ; Chorilli, Marlus (Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2022) [Artigo]
Breast cancer is the commonest cancer among women, with more than 2 million cases per year and a lethality rate of 17.7%. The treatment of breast cancer still being a challenge due to the high heterogeneity of tumor cells. ... -
Glioblastoma multiforme targeted delivery of docetaxel using bevacizumab-modified nanostructured lipid carriers impair in vitro cell growth and in vivo tumor progression
Di Filippo, Leonardo Delello; Lobato Duarte, Jonatas ; ; ; ; Hugo Sousa Araújo, Victor ; Delbone Figueiredo, Ingrid ; Barretto-de-Souza, Lucas ; Miguel Sábio, Rafael ; Sasso-Cerri, Estela et al. (International Journal of Pharmaceutics, 2022) [Artigo]
Glioblastoma multiforme (GBM) is the most common malignant brain cancer, characterized by high invasiveness and poor prognosis. Docetaxel (DTX) is a chemotherapeutic drug with promising anti-tumor properties. However, ... -
HPMCAS-Coated Alginate Microparticles Loaded with Ctx(Ile21)-Ha as a Promising Antimicrobial Agent against Salmonella Enteritidis in a Chicken Infection Model
Roque-Borda, Cesar Augusto; Souza Saraiva, Mauro de Mesquita ; Monte, Daniel F. M. ; Rodrigues Alves, Lucas Bocchini ; de Almeida, Adriana Maria ; Ferreira, Taísa Santiago ; de Lima, Túlio Spina ; Benevides, Valdinete Pereira ; Cabrera, Julia Memrava ; et al. (ACS Infectious Diseases, 2022) [Artigo]
Salmonella enterica subsp. enterica serovar Enteritidis (S. Enteritidis) in poultry is most often transmitted by the fecal-oral route, which can be attributed to high population density. Upon encountering the innate immune ... -
Antifungal activity and toxicity of an octyl gallate-loaded nanostructured lipid system on cells and nonmammalian animals
Singulani, Junya L; Scorzoni, Liliana ; Da Silva, Patricia B ; Nazaré, Ana C ; Polaquini, Carlos R ; Baveloni, Franciele G ; Chorilli, Marlus ; Regasini, Luis O ; Fusco-Almeida, Ana M ; Mendes-Giannini, Maria J.S. (Future Microbiology, 2022) [Artigo]
Aim: Octyl gallate (OG) loaded into a nanostructured lipid system (NLS) was tested for antifungal activity and in vitro and in vivo toxicity. Methods & Results: The features of NLS-OG were analyzed by dynamic light scattering ... -
Solid lipid nanoparticles loaded with curcumin: Development and in vitro toxicity against CT26 cells
; ; ; ; ; ; ; ; ; Fernandes, Richard Perosa et al. (Nanomedicine, 2022) [Artigo]
Aim: To develop a new curcumin carrier consisting of murumuru butter nanoparticles (SLN-Cs). Methods: A phase-inversion temperature method was used to produce SLN-Cs. The interaction of SLN-Cs with murine colon adenocarcinoma ... -
Understanding the role of electrostatic interactions on the association of 5-fluorouracil to chitosan-TPP nanoparticles
dos Santos, Aline Martins; Carvalho, Suzana Gonçalves ; Ferreira, Leonardo Miziara Barboza ; Chorilli, Marlus ; Gremião, Maria Palmira Daflon (Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2022) [Artigo]
Judicious design strategies should be considered powerful tools to better control the properties of chitosan (CS) and tripolyphosphate (TPP) particles. This study focused on understanding the role of the charge properties ... -
An overview of the use of central venous catheters impregnated with drugs or with inorganic nanoparticles as a strategy in preventing infections
Corrêa Carvalho, Gabriela; Miguel Sábio, Rafael ; Spósito, Larissa ; ; Chorilli, Marlus (International Journal of Pharmaceutics, 2022) [Resenha]
Central venous catheter (CVC) is a medical device widely used in therapeutics to avoid repetitive venipuncture. Although its use is advantageous, it is possible to highlight limitations, such as the risk of catheter-related ... -
Lipid Nanomaterials for Targeted Delivery of Dermocosmetic Ingredients: Advances in Photoprotection and Skin Anti-Aging
; ; ; ; ; ; ; Chorilli, Marlus; ; et al. (Nanomaterials, 2022) [Resenha]
Despite the health benefits of the sun, overexposure to solar radiation without proper precautions can cause irreversible damage to exposed skin. In the search for balance between the risks and benefits of exposure to solar ... -
Gene Therapy Based on Lipid Nanoparticles as Non-viral Vectors for Glioma Treatment
; ; Araújo, Victor Hugo Sousa; Filippo, Leonardo Delello Di ; Duarte, Jonatas Lobato ; ; Chorilli, Marlus (Current Gene Therapy, 2021) [Resenha]
Gliomas are primary brain tumors originating from glial cells, representing 30% of all Central Nervous System (CNS) neoplasia. Among them, the astrocytoma grade IV (glioblastoma multiforme) is the most common, presenting ... -
Doxorubicin nanoformulations on therapy against cancer: An overview from the last 10 years
; ; ; Kurnik, Isabelle S.; ; Araujo, Victor H.S. ; ; ; ; et al. (Materials Science and Engineering C, 2022) [Resenha]
Doxorubicin (DOX) is a natural antibiotic with antineoplastic activity. It has been used for over 40 years and remains one of the most used drugs in chemotherapy for a variety of cancers. However, cardiotoxicity limits its ... -
Design and synthesis of hybrid compounds as epigenetic modifiers
Lopes, Juliana Romano; Prokopczyk, Igor Muccilo ; Gerlack, Max ; Chin, Chung Man ; Dos Santos, Jean Leandro (Pharmaceuticals, 2021) [Artigo]
Epigenetic modifiers acting through polypharmacology mechanisms are promising compounds with which to treat several infectious diseases. Histone deacetylase (HDAC) enzymes, mainly class I, and extra-terminal bromodomains ... -
Deficiency of vitamins C and E in women of childbearing age in Brazil: A systematic review and meta-analysis
Lucchetta, Rosa Camila; Cavicchioli, Sophia de Andrade ; Gini, Ana Luísa Rodriguez ; Forgerini, Marcela ; Varallo, Fabiana Rossi ; de Nadai, Mariane Nunes ; Fernandez-Llimos, Fernando ; Mastroianni, Patricia de Carvalho (Sao Paulo Medical Journal, 2021) [Artigo]
BACKGROUND: Despite the several options available for supplements containing vitamins C and E, evidence regarding the prevalence of deficiency or insufficiency of these vitamins is weak. OBJECTIVES: To estimate the prevalence ... -
Epirubicin: Biological Properties, Analytical Methods, and Drug Delivery Nanosystems
; Dutra, Jessyca Aparecida Paes; Di Filippo, Leonardo Delello ; Junior, Alberto Gomes Tavares ; ; ; Chorilli, Marlus (Critical Reviews in Analytical Chemistry, 2021) [Resenha]
Epirubicin (EPI) is a chemotherapeutic agent belonging to the anthracycline drug class indicated for treating several tumors. It acts by suppressing the DNA and RNA synthesis by intercalating between their base pair. ... -
Lipid nanocarriers for hyperproliferative skin diseases
; de Souza, Ana L. R.; Dos Santos, Fernanda K. ; ; ; ; ; ; Gremião, Maria P. D. ; Chorilli, Marlus (Cancers, 2021) [Resenha]
Hyperproliferative skin diseases (HSD) are a group of diseases that include cancers, pre-cancerous lesions and diseases of unknown etiology that present different skin manifestations in terms of the degree and distribution ... -
Lycopene: From tomato to its nutraceutical use and its association with nanotechnology
Carvalho, Gabriela Corrêa; de Camargo, Bruna Almeida Furquim ; de Araújo, Jennifer Thayanne Cavalcante ; Chorilli, Marlus (Trends in Food Science and Technology, 2021) [Resenha]
Background: Lycopene, a red-colored carotenoid, has several biological properties, such as antioxidant, cardioprotective, antihypercholesterolemic, antidiabetic, antimicrobial, photoprotector and anticancer, making desirable ... -
Overview of chitosan-based nanosystems for prostate cancer therapy
de Araújo, Jennifer Thayanne Cavalcante; Tavares Junior, Alberto Gomes ; Di Filippo, Leonardo Delello ; Duarte, Jonatas Lobato ; Ribeiro, Tais de Cássia ; Chorilli, Marlus (European Polymer Journal, 2021) [Resenha]
Prostate cancer is considered a non-cutaneous cancer and has high prevalence and mortality rates worldwide. Chemotherapeutic agents have several side effects due to non-specific systemic biodistribution. Alternatively, ... -
Piperine for treating breast cancer: A review of molecular mechanisms, combination with anticancer drugs, and nanosystems
Quijia, Christian Rafael; Chorilli, Marlus (Phytotherapy Research, 2022) [Resenha]
Piperine (PIP) is an alkaloid found primarily in Piper longum, and this natural compound has been shown to exert effects on proliferation and survival against various types of cancer. In particular, PIP has potent inhibitory ... -
Reversed-phase high-performance liquid chromatography: A fast and efficient analytical method to quantify docetaxel-loaded pegylated liposomes in release study
Aires-Fernandes, Mariza; ; Damiani Victorelli, Francesca ; Scanavez Ferreira, Paula ; Pironi, Andressa Maria ; Chorilli, Marlus (Journal of Separation Science, 2021) [Artigo]
Docetaxel is an anticancer that belongs to the family of taxanes and acts in the inhibition of cell proliferation through the polymerization of microtubules. The aim of this study was the development and validation of a ... -
The emerging landscapes to drug delivery systems for the treatment of pancreatic cancer
Magri, Agnes; Baveloni, Franciele Garcia ; de Camargo, Bruna Almeida Furquim ; Chorilli, Marlus (Current Medicinal Chemistry, 2021) [Resenha]
Pancreatic Ductal Adenocarcinoma (PDA) is a highly metastatic tumor, and the liver is its first target, which restricts the use of medications. PDA is considered one of the most aggressive types of cancer in the world, ...