RSS 1.0Departamento de Fármacos e Medicamentos
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Association between Development of Dementia and Use of Benzodiazepines: A Systematic Review and Meta-Analysis
; da Mata, Barbara Paes Miglioli
; Mastroianni, Patricia de Carvalho (Pharmacotherapy, 2018) [Artigo]
Study Objective: The use of benzodiazepines and the development of dementia is controversial, with studies indicating that benzodiazepines could be either a protective factor or a risk factor for dementia, or no association ... -
Antimicrobial photodynamic therapy mediated by curcumin-loaded polymeric nanoparticles in a murine model of oral candidiasis
Sakima, Vinicius Tatsuyuji; Barbugli, Paula Aboud ; Cerri, Paulo Sérgio ; Chorilli, Marlus ; Carmello, Juliana Cabrini ; Pavarina, Ana Cláudia ; De Oliveira Mima, Ewerton Garcia (Molecules, 2018) [Artigo]
Antimicrobial photodynamic therapy (aPDT) has been proposed as an alternative method for oral candidiasis (OC), while nanocarriers have been used to improve the water solubility of curcumin (CUR). The aim of this study is ... -
Evolution of green chemistry and its multidimensional impacts: A review
de Marco, Bianca Aparecida; Rechelo, Bárbara Saú ; Tótoli, Eliane Gandolpho ; Kogawa, Ana Carolina ; Salgado, Hérida Regina Nunes (Saudi Pharmaceutical Journal, 2018) [Artigo]
The growing process of industrialization was a milestone for world economic evolution. Since the 1940s, social movements have revolutionized green chemistry and provided shifts in industrial positions and sustainable ... -
Potential of the association of dodecyl gallate with nanostructured lipid system as a treatment for paracoccidioidomycosis: In vitro and in vivo efficacy and toxicity
Singulani, Junya de Lacorte; Scorzoni, Liliana ; Lourencetti, Natália Manuela Strohmayer ; Oliveira, Luana Rossi ; Conçolaro, Rosana Silva ; da Silva, Patricia Bento ; Nazaré, Ana Carolina ; Polaquini, Carlos Roberto ; Victorelli, Francesca Damiani ; Chorilli, Marlus et al. (International Journal of Pharmaceutics, 2018) [Artigo]
Paracoccidioidomycosis (PCM) is a systemic mycosis endemic in Latin America, caused by Paracoccidioides spp. A limited number of antifungal agents are available and the search for new compounds has increased. Additionally, ... -
Study of triamcinolone release and mucoadhesive properties of macroporous hybrid films for oral disease treatment
Oshiro, Joaõ Augusto; Nasser, Neima Jamil ; Chiari-Andreó, Bruna Galdorfini ; ; Chiavacci, Leila Aparecida (Biomedical Physics and Engineering Express, 2018) [Artigo]
The aim of this study was to develop macroporous mucoadhesive films from ureasil-polyether materials for future application in oral disease treatment. The films were prepared via the sol-gel route by using polyethylene ... -
Potential Adverse Drug Events and Nephrotoxicity Related to Prophylaxis With Omeprazole for Digestive Disorders: A Prospective Cohort Study
Varallo, Fabiana Rossi; ; de Oliveira, Alice Rosa Alves ; Mastroianni, Patricia de Carvalho (Clinical Therapeutics, 2018) [Artigo]
Purpose: The purpose of this study was to assess whether prophylaxis for digestive disorders with omeprazole is a risk factor for adverse drug events (ADEs) and kidney impairment. Methods: This was a 9-month, prospective, ... -
Development of differentiated pharmaceutical packaging for greater autonomy and quality of life for physically and visually impaired patients
Cernic, Beatriz Gamberini; Kogawa, Ana Carolina ; Salgado, Hérida Regina Nunes (Saudi Pharmaceutical Journal, 2018) [Artigo]
20–45% of the world population present special needs, permanent or provisional. This index is higher than that presented by the WHO, which determines that 10% of a country's population has some kind of disabled, in times ... -
A Critical Review of Properties and Analytical Methods for the Determination of Docetaxel in Biological and Pharmaceutical Matrices
da Silva, Gilmar Hanck; Fernandes, Mariza Aires ; Trevizan, Lucas Noboru Fatori ; de Lima, Felipe Tita ; Eloy, Josimar O. ; Chorilli, Marlus (Critical Reviews in Analytical Chemistry, 2018) [Resenha]
Docetaxel (DTX) is an antineoplastic agent of the second generation of the taxoid family. It is a semi-synthetic drug prepared from a precursor extracted of the plant Taxus baccata. The commercial formulation of DTX, ... -
Status of Rifaximin: A Review of Characteristics, Uses and Analytical Methods
Kogawa, Ana Carolina; Salgado, Hérida Regina Nunes (Critical Reviews in Analytical Chemistry, 2018) [Resenha]
Rifaximin, an oral antimicrobial, has many advantages because it is selective intestine, has minimal adverse effects and is used for the treatment of some diseases such as hepatic encephalopathy, irritable bowel syndrome, ... -
Analytical Methods for the Determination of Rosuvastatin in Pharmaceutical Formulations and Biological Fluids: A Critical Review
; ; ; ; Salgado, Hérida Regina Nunes; (Critical Reviews in Analytical Chemistry, 2018) [Resenha]
Rosuvastatin calcium (ROS), (Figure 1) belongs to the “statins” group, which is the 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor. This drug is indicated for dyslipidemias treatment and can help to ... -
Spectrophotometry in infrared region: A new, low cost and green way to analyze tablets of rifaximin
Kogawa, Ana Carolina; Salgado, Hérida Regina Nunes (Current Pharmaceutical Analysis, 2018) [Artigo]
Background: Rifaximin is an oral antimicrobial, which, until now, does not have standardized analytical methods in most official compendia. The literature shows few methods for the detection of drug, but has no analytical ... -
Metronidazole-loaded polyethyleneimine and chitosan-based liquid crystalline system for treatment of staphylococcal skin infections
Victorelli, Francesca Damiani; Calixto, Giovana Maria Fioramonti ; Dos Santos Ramos, Matheus Aparecido ; Bauab, Taís Maria ; Chorilli, Marlus (Journal of Biomedical Nanotechnology, 2018) [Artigo]
Staphylococcus aureus is a common gram-positive bacterium of the human skin microbiota. It is also a dangerous pathogen that can cause serious and even lethal skin infections. The topical administration of metronidazole ... -
An inhalable powder formulation based on micro-and nanoparticles containing 5-fluorouracil for the treatment of metastatic melanoma
; ; ; ; ; Gremião, Maria Palmira Daflon; ; (Nanomaterials, 2018) [Artigo]
Melanoma is the most aggressive and lethal type of skin cancer, with a poor prognosis because of the potential for metastatic spread. The aim was to develop innovative powder formulations for the treatment of metastatic ... -
Characteristics, Properties and Analytical Methods of Paclitaxel: A Review
Alves, Renata Carolina; Fernandes, Richard Perosa ; Eloy, Josimar O. ; Salgado, Hérida Regina Nunes ; Chorilli, Marlus (Critical Reviews in Analytical Chemistry, 2018) [Resenha]
Paclitaxel is a diterpenoid pseudoalkaloid, isolated from Taxus brevifolia, and is largely used as an antitumoral drug. The formulation of paclitaxel known as Taxol® employs a mixture of Cremophor EL and dehydrated ethanol, ... -
Besifloxacin: A Critical Review of Its Characteristics, Properties, and Analytical Methods
Tótoli, Eliane Gandolpho; Salgado, Hérida Regina Nunes (Critical Reviews in Analytical Chemistry, 2018) [Resenha]
Bacterial conjunctivitis has high impact on the health of the population, since it represents more than a third of ocular pathologies reported by health services worldwide. There is a high incidence of bacterial resistance ... -
Gellan gum/pectin beads are safe and efficient for the targeted colonic delivery of resveratrol
Prezotti, Fabíola Garavello; Boni, Fernanda Isadora ; Ferreira, Natália Noronha ; ; ; ; ; Gremião, Maria Palmira Daflon ; Cury, Beatriz Stringhetti Ferreira ; (Polymers, 2018) [Artigo]
This work addresses the establishment and characterization of gellan gum:pectin (GG:P) biodegradable mucoadhesive beads intended for the colon-targeted delivery of resveratrol (RES). The impact of the polymer carrier system ... -
An overview of polymeric dosage forms in buccal drug delivery: State of art, design of formulations and their in vivo performance evaluation
Fonseca-Santos, Bruno; Chorilli, Marlus (Materials Science and Engineering C, 2018) [Resenha]
Owing to the ease of the administration, the oral cavity is an attractive site for the delivery of drugs. The main difficulty for administration via the buccal route is an effective physiological removal mechanism of the ... -
Development and characterization of p1025-loaded bioadhesive liquid-crystalline system for the prevention of Streptococcus mutans biofilms
Calixto, Giovana Maria Fioramonti; Duque, Cristiane ; Aida, Kelly Limi ; dos Santos, Vanessa Rodrigues ; Massunari, Loiane ; Chorilli, Marlus (International Journal of Nanomedicine, 2017) [Artigo]
Formation of a dental biofilm by Streptococcus mutans can cause dental caries, and remains a costly health problem worldwide. Recently, there has been a growing interest in the use of peptidic drugs, such as peptide p1025, ... -
Epigenetic regulatory mechanisms induced by resveratrol
Fernandes, Guilherme Felipe Santos; Silva, Gabriel Dalio Bernardes ; Pavan, Aline Renata ; Chiba, Diego Eidy ; Chin, Chung Man ; Dos Santos, Jean Leandro (Nutrients, 2017) [Resenha]
Resveratrol (RVT) is one of the main natural compounds studied worldwide due to its potential therapeutic use in the treatment of many diseases, including cancer, diabetes, cardiovascular diseases, neurodegenerative diseases ... -
Quantification of rifaximin in tablets by an environmentally friendly visible spectrophotometric method
; Kogawa, Ana Carolina; Salgado, Hérida Regina Nunes (Current Pharmaceutical Analysis, 2017) [Artigo]
Introduction: Rifaximin is an antibiotic with a wide spectrum of antibacterial activity. Due to its non-absorbable nature and mechanism of action, it is commonly used for treating travelers’ diarrhea. It still does not ...