RSS 1.0Departamento de Fármacos e Medicamentos
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Estratégias para intervenção em complexos repressores do gene de gamaglobina contendo Histona Deacetilase (HDAC-1 e HDAC-2)
Santos, Jean Leandro dos
(2023) [Plano de gestão de dados]
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Temozolomide: An Overview of Biological Properties, Drug Delivery Nanosystems, and Analytical Methods
Dutra, Jessyca Aparecida Paes; ; Tavares Junior, Alberto Gomes ; Di Filippo, Leonardo Delello ; Carvalho, Suzana Gonçalves ; Chorilli, Marlus (Current pharmaceutical design, 2022) [Artigo]
Temozolomide (TMZ) is an imidazotetrazine prodrug used to treat glioblastoma multiforme. Its physicochemical properties and small size confer the ability to cross the blood-brain barrier. The antitumor activity depends on ... -
In Vitro Skin Co-Delivery and Antibacterial Properties of Chitosan-Based Microparticles Containing Ascorbic Acid and Nicotinamide
Di Filippo, Leonardo Delello; Duarte, Jonatas Lobato ; Roque-Borda, Cesar Augusto ; Pavan, Fernando Rogério ; Meneguin, Andreia Bagliotti ; Chorilli, Marlus ; ; ; Spagnol, Caroline Magnani ; Correa, Marcos Antônio (Life, 2022) [Artigo]
Vitamins are widely found in nature, for example, in plants and fruits. Ascorbic acid and nicotinamide are examples of these compounds that have potent antioxidant properties, besides stimulating collagen production and ... -
In situ synthesis of piperine-loaded MIL-100 (Fe) in microwave for breast cancer treatment
Quijia, Christian Rafael; ; Fernandes, Richard Perosa ; Sábio, Rafael Miguel ; Frem, Regina ; Chorilli, Marlus (Journal of Drug Delivery Science and Technology, 2022) [Artigo]
Piperine (PIP) is a natural alkaloid that has strong activity against breast cancer. However, due to its low solubility and bioavailability, it is unfeasible for clinical applications. Herein, we proposed an in-situ method ... -
Cetyltrimethylammonium bromide in the synthesis of mesoporous silica nanoparticles: General aspects and in vitro toxicity
Carvalho, Gabriela Corrêa; Marena, Gabriel Davi ; ; ; Sábio, Rafael Miguel ; ; Bauab, Taís Maria ; Chorilli, Marlus (Advances in Colloid and Interface Science, 2022) [Resenha]
Pharmaceutical nanotechnology has become a trend with incalculable advantages in the applicability of systems in the controlled, safe and effective release of drugs. Among the nanotechnological nanoparticles, the mesoporous ... -
Insights for Alzheimer's disease pharmacotherapy and current clinical trials
Nascimento, A. L.C.S.; ; Carvalho, A. C.S. ; Frigieri, I. ; Alves, R. C. ; Chorilli, M. (Neurochemistry International, 2022) [Resenha]
Over the years, the scientific community has sought improvements in the life quality of patients diagnosed with Alzheimer's disease (AD). Synaptic loss and neuronal death observed in the regions responsible for cognitive ... -
An Updated Review on Properties, Nanodelivery Systems, and Analytical Methods for the Determination of 5-Fluorouracil in Pharmaceutical and Biological Samples
Dos Santos, Aline Martins; Junior, Alberto Gomes Tavares ; Carvalho, Suzana Gonçalves ; Chorilli, Marlus (Current Pharmaceutical Design, 2022) [Resenha]
5-Fluorouracil (5-FU) is an antimetabolite drug used for over 70 years as first-line chemotherapy to treat various types of cancer, such as head, neck, breast, and colorectal cancer. 5-FU acts mainly by inhibiting thymidylate ... -
Solid dispersions based on chitosan/hypromellose phthalate blends to modulate pharmaceutical properties of zidovudine
Pedreiro, Liliane Neves; Boni, Fernanda Isadora ; Cury, Beatriz Stringhetti Ferreira ; Ferreira, Natália Noronha ; Gremião, Maria Palmira Daflon (Pharmaceutical Development and Technology, 2022) [Artigo]
Zidovudine (AZT) has been widely used alone or in combination with other antiretroviral drugs for the treatment of human immunodeficiency virus. Its erratic oral bioavailability necessitates frequent administration of high ... -
Photodynamic therapy-mediated hypericin-loaded nanostructured lipid carriers against vulvovaginal candidiasis
Sato, Mariana Rillo; ; Rodero, Camila Fernanda ; Boni, Fernanda Isadora ; Araújo, Victor Hugo Sousa ; Bauab, Taís Maria ; ; ; Chorilli, Marlus (Journal of Medical Mycology, 2022) [Artigo]
Introduction and Aim: The indiscriminate use and adverse effects of the main conventional antifungal agents compromise the effectiveness of treating vulvovaginal candidiasis (VVC), mainly caused by the species Candida ... -
Functionalized lipid-based drug delivery nanosystems for the treatment of human infectious diseases
Almeida Furquim de Camargo, Bruna; ; Gonçalves Carvalho, Suzana ; Corrêa Carvalho, Gabriela ; Delello Di Filippo, Leonardo ; Sousa Araújo, Victor Hugo ; Lobato Duarte, Jonatas ; Polli Silvestre, Amanda Letícia ; Bauab, Taís Maria ; Chorilli, Marlus (Critical Reviews in Microbiology, 2022) [Resenha]
Infectious diseases are still public health problems. Microorganisms such as fungi, bacteria, viruses, and parasites are the main causing agents related to these diseases. In this context, the search for new effective ... -
Recent Trends in Drug Development for the Treatment of Adenocarcinoma Breast Cancer: Thiazole, Triazole, and Thiosemicarbazone Analogues as Efficient Scaffolds
Scarim, Cauê Benito; Chin, Chung Man (Anti-Cancer Agents in Medicinal Chemistry, 2022) [Resenha]
Thiazoles, triazoles, and thiosemicarbazones function as efficient scaffolds in compounds for the treatment of several illnesses, including cancers. In this review article, we have demonstrated various studies involving ... -
Insight into Recent Drug Discoveries against Trypanosomatids and Plasmodium spp Parasites: New Metal-based Compounds
Scarim, Cauê Benito; de Farias, Renan Lira ; Chiba, Diego Eidy ; Chin, Chung Man (Current Medicinal Chemistry, 2022) [Resenha]
Scaffolds of metal-based compounds can act as pharmacophore groups in several ligands to treat various diseases, including tropical infectious diseases (TID). In this review article, we investigate the contribution of these ... -
New and potential properties, characteristics, and analytical methods of ferulic acid: A review
Marcato, Danieli Camilo; Spagnol, Caroline Magnani ; Salgado, Hérida Regina Nunes ; Isaac, Vera Lucia Borges ; Corrêa, Marcos Antonio (Brazilian Journal of Pharmaceutical Sciences, 2022) [Artigo]
Phenolic compounds are widely distributed in the plant kingdom and in the microorganisms. Cinnamic acid and its hydroxylated derivative—ferulic acid, are phenolic compounds. Ferulic acid possesses antioxidant potential, ... -
Optimization of nanoemulsified systems containing lamellar phases for co-delivery of celecoxib and endoxifen to the skin aiming for breast cancer chemoprevention and treatment
; ; ; Chorilli, Marlus; (Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2022) [Artigo]
We proposed an innovative nanoemulsified system containing lamellar phases (NLP) produced by a low-energy method to enable the local-transdermal co-delivery of celecoxib and endoxifen as a potential strategy for breast ... -
Targeted Liposomes: A Nonviral Gene Delivery System for Cancer Therapy
; Dutra, Jessyca Aparecida Paes; Tofani, Larissa Bueno ; de Araújo, Jennifer Thayanne Cavalcante ; Di Filippo, Leonardo Delello ; ; Chorilli, Marlus (Pharmaceutics, 2022) [Resenha]
Cancer is the second most frequent cause of death worldwide, with 28.4 million new cases expected for 2040. Despite de advances in the treatment, it remains a challenge because of the tumor heterogenicity and the increase ... -
Mucoadhesive Nanosystems for Nose-to-Brain Drug Delivery in the Treatment of Central Nervous System Diseases
Di Filippo, Leonardo Delello; Duarte, Jonatas ; ; Tavares Júnior, Alberto Gomes ; Araújo, Victor ; Borda, Cesar Augusto Roque ; Vicente, Eduardo Festozo ; Chorilli, Marlus (Current Medicinal Chemistry, 2022) [Artigo]
The diseases affecting the Central Nervous System (CNS) can have varied etiopathology, but they have in common silent progression, global incidence, and significant impacts on the quality of life of patients and public ... -
Development of a Mucoadhesive Liquid Crystal System for the Administration of Rifampicin Applicable in Tuberculosis Therapy
Santos, Kaio Pini; Rodero, Camila Fernanda ; Ribeiro, Camila Maríngolo ; Gremião, Maria P. D. ; Peccinini, Rosângela Gonçalves ; Pavan, Fernando Rogerio ; ; ; Chorilli, Marlus (Life, 2022) [Artigo]
Since 1966, rifampicin (RIF) has been considered one of the most potent drugs in the treatment of tuberculosis (TB), which is caused by infection with M. tuberculosis (Mtb). New nanostructured formulations for RIF delivery ... -
MIL-100(Fe) Sub-Micrometric Capsules as a Dual Drug Delivery System
Abuçafy, Marina Paiva; Frem, Regina Celia Galvao ; Polinario, Giulia ; Pavan, Fernando Rogerio ; ; ; ; ; Chiavacci, Leila Aparecida (International Journal of Molecular Sciences, 2022) [Artigo]
Nanoparticles of metal–organic frameworks (MOF NPs) are crystalline hybrid micro- or mesoporous nanomaterials that show great promise in biomedicine due to their significant drug loading ability and controlled release. ... -
The association of extracts of Achyrocline satureioides and the fungus Beauveria bassiana against the tick Rhipicephalus microplus
Fantatto, Rafaela Regina; ; ; Sorrechia, Rodrigo ; ; Pietro, Rosemeire Cristina Linhari Rodrigues (Experimental and Applied Acarology, 2022) [Artigo]
The tick Rhipicephalus microplus (Canestrini) is a major economic hurdle to the global livestock industry. The incorrect and indiscriminate control carried out by synthetic chemical compounds has contributed to the emergence ... -
Sustainable Antibacterial Activity of Polyamide Fabrics Containing ZnO Nanoparticles
Garcia, Mariana Marin; Da Silva, Bruna Lallo ; Sorrechia, Rodrigo ; Pietro, Rosemeire Cristina Linhari Rodrigues ; Chiavacci, Leila Aparecida (ACS Applied Bio Materials, 2022) [Artigo]
In this study, we present an unprecedented study on the influence of parameters such as dyeing, softening, and number of washes on the maintenance of the antibacterial activity of polyamide fabrics containing zinc oxide ...