RSS 1.0Departamento de Fármacos e Medicamentos
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Recent advances in the use of metallic nanoparticles with antitumoral action - Review
Da Silva, Patricia Bento
; Machado, Rachel Temperani Amaral ; Pironi, Andressa Maria ; Alves, Renata Carolina ; De Araújo, Patricia Rocha ; Dragalzew, Amanda Cutrim ; Dalberto, Ingrid ; Chorilli, Marlus (Current Medicinal Chemistry, 2019) [Artigo]
The term cancer represents a set of more than 100 diseases that are caused due to an uncontrolled growth of cells; and their subsequent spread to the other tissues and organs of the body by a phenomenon, called ‘metastasis’. ... -
Forced degradation behavior of two-drug combinations: Isolation and characterization of major degradation products by LC-MS
Sversut, Rúbia Adrieli; ; ; ; Salgado, Hérida Regina Nunes (Microchemical Journal, 2019) [Artigo]
Oxytetracycline (OTC) belongs to the antimicrobial class, diclofenac sodium (DICLO) and piroxicam (PIRO) are nonsteroidal anti-inflammatory drugs. Fixed-dose combinations of OTC with DICLO or PIRO, available as extended ... -
Chitosan-Based Drug Delivery Systems for Optimization of Photodynamic Therapy: a Review
Calixto, Giovana Maria Fioramonti; de Annunzio, Sarah Raquel ; Victorelli, Francesca Damiani ; Frade, Maria Lucia ; Ferreira, Paula Scanavez ; Chorilli, Marlus ; Fontana, Carla Raquel (AAPS PharmSciTech, 2019) [Resenha]
Drug delivery systems (DDS) can be designed to enrich the pharmacological and therapeutic properties of several drugs. Many of the initial obstacles that impeded the clinical applications of conventional DDS have been ... -
Eco-friendly evaluation of rifaximin in tablets by capillary electrophoresis
Kogawa, Ana Carolina; ; Salgado, Hérida Regina Nunes (Journal of Chromatographic Science, 2019) [Artigo]
Rifaximin, an oral antimicrobial, has no standardized analytical methods in many official compendia. In this context, the aim was to develop and validate an analytical method by capillary electrophoresis for quantification ... -
Mucoadhesive In Situ Gelling Liquid Crystalline Precursor System to Improve the Vaginal Administration of Drugs
de Araújo, Patricia Rocha; Calixto, Giovana Maria Fioramonti ; da Silva, Isabel Cristiane ; de Paula Zago, Lucas Henrique ; ; Pavan, Fernando Rogério ; ; Fontana, Carla Raquel ; Chorilli, Marlus (AAPS PharmSciTech, 2019) [Artigo]
The vaginal mucosa is a very promising route for drug administration due to its high permeability and the possibility to bypass first pass metabolism; however, current vaginal dosage forms present low retention times due ... -
Study of the colloidal stability and optical properties of sunscreen creams
Saito, Gustavo Pereira; Bizari, Mariana ; Cebim, Marco Aurélio ; Correa, Marcos Antonio ; Junior, Miguel Jafelicci ; Davolos, Marian Rosaly (Ecletica Quimica, 2019) [Artigo]
Sunscreen formulations containing inorganic/organic filters or mixture of them were synthesized by oil/water dispersion. The viscosity measurements show that sunscreen formulations are time-dependent non-Newtonian fluids. ... -
Atorvastatin: A review of analytical methods for pharmaceutical quality control and monitoring
Kogawa, Ana Carolina; ; Salgado, Hérida Regina Nunes (Journal of AOAC International, 2019) [Resenha]
Background: Atorvastatin, a lipid-regulating drug, was the best-selling drug in the world in the early 2000s. Thus, monitoring of this drug is important because it is accessible to a large portion of the population. In ... -
New insights towards mesoporous silica nanoparticles as a technological platform for chemotherapeutic drugs delivery
; ; Ribeiro, Taís C.; ; Chorilli, Marlus (International Journal of Pharmaceutics, 2019) [Resenha]
Mesoporous silica nanoparticles (MSNs)displays interesting properties for biomedical applications such as high chemical stability, large surface area and tunable pores diameters and volumes, allowing the incorporation of ... -
Safety assessment of omeprazole use: A review
Forgerini, Marcela; Mieli, Stephania ; Mastroianni, Patrícia de Carvalho (Sao Paulo Medical Journal, 2018) [Resenha]
BACKGROUND: Risks regarding hospital admission due to adverse drug reactions and drug interactions from use of omeprazole have been reported. The question guiding the present review was “Which adverse events occur in ... -
A Review of Analytical Methods for p-Coumaric Acid in Plant-Based Products, Beverages, and Biological Matrices
Ferreira, Paula Scanavez; Victorelli, Francesca Damiani ; Fonseca-Santos, Bruno ; Chorilli, Marlus (Critical Reviews in Analytical Chemistry, 2019) [Resenha]
p-Coumaric acid (p-CA), also known as 4-hydroxycinnamic acid, is a phenolic acid, which has been widely studied due to its beneficial effects against several diseases and its wide distribution in the plant kingdom. This ... -
A Critical Review of Properties and Analytical/Bioanalytical Methods for Characterization of Cetuximab
Hanck-Silva, Gilmar; Fatori Trevizan, Lucas Noboru ; ; de Lima, Felipe Tita ; ; Chorilli, Marlus (Critical Reviews in Analytical Chemistry, 2019) [Resenha]
Cetuximab (CTX) is a chimeric monoclonal antibody (mAb) able to selectively bind to the epidermal growth factor receptor (EGFR), resulting in inhibition of EGF linkage and phosphorylation cascade interruption. As a result, ... -
Characteristics, Biological Properties and Analytical Methods of Piperine: A Review
Quijia, Christian Rafael; Chorilli, Marlus (Critical Reviews in Analytical Chemistry, 2019) [Resenha]
Piperine (PIP) is a natural alkaloid isolated from Piper longum L. that presents antioxidant, anticonvulsant, antimicrobial, neuroprotective, larvicidal, antiparasitic, anticancer effect and other pharmacological properties. ... -
Compliance and drug-related problems in probable Alzheimer's disease elderly
Mastroianni, Patrícia De Carvalho; Forgerini, Marcela (International Psychogeriatrics, 2019) [Carta]
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Application of the Principles of Green Chemistry for the Development of a New and Sensitive Method for Analysis of Ertapenem Sodium by Capillary Electrophoresis
Pedroso, Tahisa Marcela; ; Salgado, Hérida Regina Nunes (International Journal of Analytical Chemistry, 2019) [Artigo]
An innovative method is validated for the analysis of ertapenem sodium by capillary electrophoresis using potassium phosphate buffer 10 mM pH 7 and 15 kV voltage, in the concentration range of 70 to 120 μg mL-1. Ertapenem ... -
Review for Analytical Methods for the Determination of Sodium Cephalothin
Rugani, Karen de Souza; Kogawa, Ana Carolina ; Salgado, Hérida Regina Nunes (Critical Reviews in Analytical Chemistry, 2019) [Resenha]
Infections are the second leading cause of global morbidity and mortality, therefore it is highly important to study the antimicrobial agents such as cephalosporins. Cephalothin, an antimicrobial agent that belongs to the ... -
Semisynthetic Derivative of Artemisia annua-Loaded Transdermal Bioadhesive for the Treatment of Uncomplicated Malaria Caused by Plasmodium falciparum in Children
; ; ; Fonseca-Santos, Bruno; ; ; ; Vilegas, Wagner ; Chorilli, Marlus ; et al. (Journal of Pharmaceutical Sciences, 2019) [Artigo]
According to the most recent World Health Organization statistics, malaria infected approximately 219 million people in 2017, with an estimate of 435,000 deaths (World Health Organization, 2018). Communities isolated from ... -
An effective mosquito-repellent topical product from liquid crystal-based tea tree oil
Fonseca-Santos, Bruno; Del Nero Pacheco, Camila ; Pinto, Mara Cristina ; Chorilli, Marlus (Industrial Crops and Products, 2019) [Artigo]
Diseases such as dengue, malaria, yellow fever and others transmitted by culicides determine high rates of morbidity and mortality, especially in tropical countries. An alternative to avoid bites is the use of repellents. ... -
A new green method for the quantitative analysis of enrofloxacin by Fourier-transform infrared spectroscopy
Tavares Rebouças, Camila; Carolina Kogawa, Ana ; Nunes Salgado, Hérida Regina (Journal of AOAC International, 2018) [Artigo]
Background: A green analytical chemistry method was developed for quantification of enrofloxacin in tablets. The drug, a second-generation fluoroquinolone, was first introduced in veterinary medicine for the treatment of ... -
New and miniaturized method for analysis of enrofloxacin in palatable tablets
de Souza, Maria Julia Martins; Kogawa, Ana Carolina ; Salgado, Hérida Regina Nunes (Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2019) [Artigo]
Enrofloxacin is an antimicrobial for oral use, from the fluoroquinolones of second-generation class, and it is the first fluoroquinolone used in veterinary for the treatment of bacterial infections. The development of ... -
Validated spectrophotometric methods for simultaneous determination of oxytetracycline associated with diclofenac sodium or with piroxicam in veterinary pharmaceutical dosage form
Sversut, Rúbia A.; ; ; ; ; Salgado, Hérida Regina Nunes (Arabian Journal of Chemistry, 2018) [Artigo]
Two simple, precise, accurate and robust UV zero and first derivative orders spectrophometric methods have been developed and validated for the simultaneous determination of oxytetracycline (OTC) associated either with ...