Departamento de Fármacos e Medicamentos
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Recent Submissions
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Highlights in Mesoporous Silica Nanoparticles as a Multifunctional Controlled Drug Delivery Nanoplatform for Infectious Diseases Treatment
(Pharmaceutical Research, 2020) [Artigo]Infectious diseases are a major global concern being responsible for high morbidity and mortality mainly due to the development and enhancement of multidrug-resistant microorganisms exposing the fragility of medicines and ... -
A Critical Review of Analytical Methods for Quantification of Amphotericin B in Biological Samples and Pharmaceutical Formulations
(Critical Reviews in Analytical Chemistry, 2020) [Resenha]Amphotericin B (AmB) is an important antifungal agent available in the clinical practice with the action mechanism related to the inhibition of ergosterol molecule present in the fungal cell wall. Given this, in order to ... -
Author Correction: Incorporation of Ursolic Acid in Liquid Crystalline Systems Improves the Antifungal Activity Against Candida sp. (Journal of Pharmaceutical Innovation, (2020), 10.1007/s12247-020-09470-0)
(Journal of Pharmaceutical Innovation, 2020) [Errata]The original version of this article unfortunately contained a mistake. The name of the 3rd author was incorrectly presented. The correct name of the 3rd author is “Matheus Aparecido dos Santos Ramos.”. -
Incorporation of Ursolic Acid in Liquid Crystalline Systems Improves the Antifungal Activity Against Candida Sp
(Journal of Pharmaceutical Innovation, 2020) [Artigo]Purpose: Infectious diseases caused by Candida sp. have high drug resistance due to the uncontrolled use of antibiotics. Among the natural products, ursolic acid (UA), a triterpene, has been increasing interest due to its ... -
Novel bioadhesive polycarbophil-based liquid crystal systems containing Melaleuca alternifolia oil as potential repellents against Aedes aegypti
(Journal of Molecular Liquids, 2020) [Artigo]Dengue, chikungunya, zika, and urban yellow fever are diseases which etiologic agents are transmitted by the bite of Aedes aegypti female mosquitoes, being responsible for serious public health problems. Essential oils, ... -
Pharmacokinetic Parameters of HIV-1 Protease Inhibitors
(ChemMedChem, 2020) [Resenha]Since the beginning of the HIV epidemic, research has been carried out to control the virus. Understanding the mechanisms of replication has given access to the various classes of drugs that over time have transformed AIDS ... -
Botanical insecticide–based nanosystems for the control of Aedes (Stegomyia) aegypti larvae
(Environmental Science and Pollution Research, 2020) [Resenha]Aedes (Stegomyia) aegypti is a cosmopolitan species that transmits arbovirus of medical importance as dengue, Zika, and chikungunya. The main strategy employed for the control of this mosquito is the use of larvicidal ... -
An Overview of Properties and Analytical Methods for Lycopene in Organic Nanocarriers
(Critical Reviews in Analytical Chemistry, 2020) [Resenha]Lycopene (LYC), a natural compound responsible for the red color of some fruits like pink grapefruit, red guava, watermelon, papaya and, mainly, present in tomatoes (Solanum lycopersicum). LYC has been extensively studied ... -
Nanoparticles for cosmetic use and its application
(Nanoparticles in Pharmacotherapy, 2019) [Capítulo de livro]Nanoparticles have been cited as a tool to solve many pharmaceutical problems, also in the cosmetic field. Some advantages in using them are to vectorize or retard the release and action of a cosmetic active substance, to ... -
Development and characterization of a novel liquid crystalline system containing sodium alginate for incorporation of trans-resveratrol intended for treatment of buccal candidiasis
(Pharmazie, 2020) [Artigo]Trans-resveratrol has antimicrobial effects; however, its hydrophobic properties hamper its incorporation into pharmaceutical formulations. The aim of this study was to develop liquid crystals and a liquid crystal precursor ... -
Synthesis and characterization of nanostructured lipid nanocarriers for enhanced sun protection factor of octyl p-methoxycinnamate
(AAPS PharmSciTech, 2020) [Artigo]Sunlight is important to health, but higher exposure to radiation causes early aging of the skin and skin damage that can lead to skin cancers. This study aimed at producing a stable octyl p-methoxycinnamate (OMC)–loaded ... -
A Critical Review of Biological Properties, Delivery Systems and Analytical/Bioanalytical Methods for Determination of Bevacizumab
(Critical Reviews in Analytical Chemistry, 2020) [Resenha]Bevacizumab is a chimeric monoclonal human-murine antibody originated from murine monoclonal antibody (muMAb A4.6.1) with the human immunoglobulin IgG1. BVZ binds the extracellular portion of vascular endothelial growth ... -
A Review of Properties, Delivery Systems and Analytical Methods for the Characterization of Monomeric Glycoprotein Transferrin
(Critical Reviews in Analytical Chemistry, 2020) [Resenha]Transferrin is a protein involved in iron uptake by cells and has been identified as a potential target for directing drug-loaded nanoparticles for cancer treatment and diagnosis. Most methods for conjugation of transferrin ... -
The role of stabilizers and mechanical processes on physico-chemical and anti-inflammatory properties of methotrexate nanosuspensions
(Journal of Drug Delivery Science and Technology, 2020) [Artigo]The aim of this study was to investigate two different mechanical processes (Ultra-turrax® and Sonication) and two stabilizers (Methyl cellulose (MC) and Poloxamer 407 (P407)) on the physico-chemical and anti-inflammatory ... -
Biological Properties and Analytical Methods for Micafungin: A Critical Review
(Critical Reviews in Analytical Chemistry, 2020) [Resenha]Micafungin is characterized as one of the most active available drugs for candidemia treatment; however, their use is also associated in prophylaxis protocols in cases of invasive fungal infections. The use of this drug ... -
Oral nanoparticles based on gellan gum/pectin for colon-targeted delivery of resveratrol
(Drug Development and Industrial Pharmacy, 2020) [Artigo]Nanoparticles based on gellan gum/pectin blends were designed for colon-targeted release of resveratrol (RES). Their impact on drug release rates and permeability were evaluated using Caco-2 cell model and mucus secreting ... -
Evaluation of polyelectrolyte and emulsion covalent crosslink of chitosan for producing mesalasine loaded submicron particles
(Brazilian Journal of Pharmaceutical Sciences, 2019) [Artigo]This study evaluates various techniques for producing mesalamine (5ASA)-loaded particles employing chitosan as a biopolymer: (1) the polyelectrolyte complexation of chitosan with phthalate hypromelose (HP), (2) the chemical ... -
Assessment of an anti-ageing structured cosmetic formulation containing goji berry
(Brazilian Journal of Pharmaceutical Sciences, 2019) [Artigo]Based on previous studies, it has been found that goji berry (GB), popularly known as a ‘miracle fruit’, has excellent antioxidant potential and can be used in the treatment of skin disorders associated with ageing. This ... -
Miniaturized turbidimetric assay: A green option for the analysis of besifloxacin in ophthalmic suspension
(Talanta, 2020) [Artigo]Besifloxacin is an important antimicrobial agent, belonging to the class of fluoroquinolones, used in the treatment of infectious conjunctivitis. Quality control of this active pharmaceutical ingredient is essential, since ... -
Synthesis and anti-inflammatory intestinal activity of new glucocorticoid derivatives
(Medicinal Chemistry Research, 2020) [Artigo]Glucocorticoids (GCs) are used worldwide in the treatment of chronic inflammatory diseases. This study describes the synthesis of new glucocorticoid derivatives and evaluates anti-inflammatory activity in rat models with ...