RSS 1.0Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP) - Botucatu
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Heterologous fibrin sealant potentiates axonal regeneration after peripheral nerve injury with reduction in the number of suture points
Leite, Ana Paula Silveira
; Pinto, Carina Guidi ; Tibúrcio, Felipe Cantore ; Sartori, Arthur Alves ; ; Barraviera, Benedito ; Ferreira, Rui Seabra ; Filadelpho, André Luis ; Matheus, Selma Maria Michelin (Injury, 2019) [Artigo]
The use of suture associated with heterologous fibrin sealant has been highlighted for reconstruction after peripheral nerve injury, having the advantage of being safe for clinical use. In this study we compared the use ... -
Hormonal and ultrasonographic characterization of the seasonal reproductive cycle of male and female Crotalus durissus terrificus
Matayoshi, Priscilla M.; ; Gasparotto, Vinícius P.O. ; Araujo, Michelle S. ; Simões, Carla R.B. ; Souza, Fabiana F. ; Oba, Eunice ; Machado, Vânia M.V. ; Júnior, Rui S.F. ; Prestes, Nereu C. (Animal Reproduction, 2018) [Artigo]
Research concerning to characterize seasonal reproductive cycle in males and females of Crotalus durissus terrificus by ultrasound and hormonal measurement. Reproductive aspects (follicular and testicular cycles, and ... -
Cytotoxic, genotoxic, and oxidative stress-inducing effect of an L-amino acid oxidase isolated from Bothrops jararacussu venom in a co-culture model of HepG2 and HUVEC cells
; ; ; ; Ferreira, R. S.; ; (International Journal of Biological Macromolecules, 2019) [Artigo]
Hepatocellular carcinoma incidence rates have increased worldwide, which encouraged the development of new chemotherapeutic drugs. L-Amino acid oxidases from snake venoms are cytotoxic towards human tumor cells in in vitro ... -
Development and comparative analysis of yeast protein extraction protocols for mass spectrometry
Almeida, Lauana Fogaça de; Moraes, Leonardo Nazário de ; Santos, Lucilene Delazari dos ; Valente, Guilherme Targino (Analytical Biochemistry, 2019) [Artigo]
Mass spectrometry is the most used method for protein identification and quantification. Here we developed four protein extraction protocols precisely for mass spectrometry, and we compared with other ones already published. ... -
Inferring putative virulence factors for Pythium insidiosum by proteomic approach
Chechi, Jéssica Luana; Franckin, Tarsila ; Barbosa, Lidiane Nunes ; Alves, Fernanda Cristina Bérgamo ; ; ; Dos Santos, Lucilene Delazari ; De Moraes Gimenes Bosco, Sandra (Medical Mycology, 2019) [Artigo]
Pythium insidiosum is the etiologic agent of pythiosis, a life-threatening disease that affects human and animals, has difficult diagnosis, and therapy. Studies on protein characterization of P. insidiosum are scarce, so ... -
Ceruloplasmin, transferrin and apolipoprotein A-II play important role in treatment’s followup of paracoccidioidomycosis patients
Sylvestre, Tatiane Fernanda; Cavalcante, Ricardo de Souza ; Silva, Julhiany de Fátima da ; ; ; ; Carvalho, Lídia Raquel de ; Santos, Lucilene Delazari dos ; Mendes, Rinaldo Poncio (PLoS ONE, 2018) [Artigo]
Paracoccidioidomycosis (PCM) is a systemic disease caused by thermodymorphic fungi of the Paracoccidioides brasiliensis complex, (Paracoccidioides spp.). Patients with PCM reveal specific cellular immune impairment. Despite ... -
Correlation between chronic venous ulcer exudate proteins and clinical profile: A cross-sectional study
Cavassan, Nayara Rodrigues Vieira; Camargo, Caio Cavassan ; de Pontes, Letícia Gomes ; Barraviera, Benedito ; Ferreira, Rui Seabra ; Miot, Hélio Amante ; Abbade, Luciana Patrícia Fernandes ; dos Santos, Lucilene Delazari (Journal of Proteomics, 2019) [Artigo]
Chronic venous ulcers affect the quality of life of patients around the world. The aims of this study were to identify the proteins expressed in chronic venous ulcer exudates, to categorize them according to their roles ... -
Comparative Proteomics of Methicillin-Resistant Staphylococcus aureus Subjected to Synergistic Effects of the Lantibiotic Nisin and Oxacillin
Bergamo Alves, Fernanda Cristina; Albano, Mariana ; Murbach Teles Andrade, Bruna Fernanda ; Chechi, Jessica Luana ; Marques Pereira, Ana Flavia ; Furlanetto, Alessandra ; Mores Rall, Vera Lucia ; Henrique Fernandes, Ana Angelica ; Santos, Lucilene Delazari dos ; et al. (Microbial Drug Resistance, 2019) [Artigo]
We investigated the responses and mechanisms of action of methicillin-resistant Staphylococcus aureus (MRSA) metabolism when exposed under sublethal concentrations of the synergistic antibacterial combination of nisin + ... -
Traceability of animal protein byproducts in ruminants by multivariate analysis of isotope ratio mass spectrometry to prevent transmission of prion diseases
Ferreira, Rui Seabra; Fossato da Silva, Daniela Alessandra ; Biscola, Natalia Perussi ; Pereira Sartori, Maria Marcia ; Denadai, Juliana Celia ; Jorge, Andre Mendes ; Santos, Lucilene Delazari dos ; Barraviera, Benedito (Journal Of Venomous Animals And Toxins Including Tropical Diseases, 2019) [Artigo]
Background: Ruminant feed containing animal byproduct proteins (ABPs) is prohibited in many countries due to its risk of transmitting prion diseases (PD). In most cases the entire herd is sacrificed, which causes great ... -
Honey bee envenoming in Santa Catarina, Brazil, 2007 through 2017: an observational, retrospective cohort study
; ; ; Ferreira Jonior, Rui Seabra; Barbosa, Alexandre Naime ; Barraviera, Benedito ; (Revista Da Sociedade Brasileira De Medicina Tropical, 2019) [Artigo]
Introduction: We evaluated the epidemiological and clinical profile of reported cases of bee sting incidents in Santa Catarina, Brazil. Methods: This retrospective cohort study included all reported cases of bee sting ... -
BjussuLAAO-II induces cytotoxicity and alters DNA methylation of cell-cycle genes in monocultured/co-cultured HepG2 cells
; ; ; Ferreira, Rui Seabra; ; (Journal Of Venomous Animals And Toxins Including Tropical Diseases, 2019) [Artigo]
Background: The use of animal venoms and their toxins as material sources for biotechnological applications has received much attention from the pharmaceutical industry. L-amino acid oxidases from snake venoms (SV-LAAOs) ... -
Transected Tendon Treated with a New Fibrin Sealant Alone or Associated with Adipose-Derived Stem Cells
(Cells, 2019) [Artigo]Tissue engineering and cell-based therapy combine techniques that create biocompatible materials for cell survival, which can improve tendon repair. This study seeks to use a new fibrin sealant (FS) derived from the venom ... -
Isolation and Functional Characterization of an Acidic Myotoxic Phospholipase A₂ from Colombian Bothrops asper Venom
(Toxins, 2017) [Artigo]Myotoxic phospholipases A₂ (PLA₂) are responsible for many clinical manifestations in envenomation by Bothrops snakes. A new myotoxic acidic Asp49 PLA₂ (BaCol PLA₂) was isolated from Colombian Bothrops asper venom using ... -
Long-Standing Motor and Sensory Recovery following Acute Fibrin Sealant Based Neonatal Sciatic Nerve Repair
(Neural plasticity, 2016) [Artigo]Brachial plexus lesion results in loss of motor and sensory function, being more harmful in the neonate. Therefore, this study evaluated neuroprotection and regeneration after neonatal peripheral nerve coaptation with ... -
Reviewer acknowledgement 2015
(Journal of Venomous Animals and Toxins Including Tropical Diseases, 2016) [Artigo]The Editor of Journal of Venomous Animals and Toxins including Tropical Diseases would like to thank all of our reviewers, both external and Editorial Board Members, who have contributed to the journal in Volume 21 (2015) ... -
BjSP, a novel serine protease from Bothrops jararaca snake venom that degrades fibrinogen without forming fibrin clots
; ; ; ; ; da Silva, Ronivaldo R.; ; Barraviera, Benedito ; Ferreira Junior, Rui S. ; (Toxicology and Applied Pharmacology, 2018) [Artigo]
Snake venom serine proteases (SVSPs) are commonly described as capable of affecting hemostasis by interacting with several coagulation system components. In this study, we describe the isolation and characterization of ... -
Serological proteomic biomarkers to identify Paracoccidioides species and risk of relapse
Sylvestre, Tatiane Fernanda; Cavalcante, Ricardo de Souza ; Da Silva, Julhiany de Fátima ; ; ; ; Carvalho, Lídia Raquel de ; Dos Santos, Lucilene Delazari ; Mendes, Rinaldo Poncio (PLoS ONE, 2018) [Artigo]
The sensitivity of the double agar gel immunodiffusion test is about 90% in patients with untreated paracoccidioidomycosis (PCM), but it is much lower in cases of relapse. In addition, serum from patients with PCM caused ... -
Neuroprotection and immunomodulation following intraspinal axotomy of motoneurons by treatment with adult mesenchymal stem cells
; ; ; ; Ferreira, R. S.; Barraviera, B. ; (Journal of Neuroinflammation, 2018) [Artigo]
Background: Treatment of spinal cord injury is dependent on neuronal survival, appropriate synaptic circuit preservation, and inflammatory environment management. In this sense, mesenchymal stem cell (MSC) therapy is a ... -
Current advances in immunological studies on the vespidae venom antigen 5: Therapeutic and prophylaxis to hypersensitivity responses
Bazon, Murilo Luiz; Silveira, Lais Helena ; ; Brochetto-Braga, Márcia Regina (Toxins, 2018) [Resenha]
Although systemic reactions caused by allergenic proteins present in venoms affect a small part of the world population, Hymenoptera stings are among the main causes of immediate hypersensitivity responses, with risk of ... -
Toxicity and motor changes in africanized honey bees (Apis mellifera l.) exposed to fipronil and imidacloprid
Bovi, Thaís S.; Zaluski, Rodrigo ; Orsi, Ricardo de Oliveira (Anais da Academia Brasileira de Ciencias, 2018) [Artigo]
This study evaluated the in vitro toxicity and motor activity changes in African-derived adult honey bees (Apis mellifera L.) exposed to lethal or sublethal doses of the insecticides fipronil and imidacloprid. Mortality ...