RSS 1.0Centro de Microscopia Eletrônica (CME) - Botucatu
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Low-dose in utero exposure to finasteride promotes developmental changes in both male and female gerbil prostates
; ; Santos, Vitória A.
; Amaro, Gustavo M. ; Calmon, Marília F. ; Rahal, Paula ; Góes, Rejane M. ; Vilamaior, Patricia S. L. ; Taboga, Sebastião R. (Environmental Toxicology, 2019) [Artigo]
The prostate is an accessory reproductive gland that is sensitive to the action of exogenous compounds known as endocrine disrupters that alter normal hormonal function. Finasteride is a widely used chemical that acts to ... -
Differences between male and female prostates in terms of physiology, sensitivity to chemicals and pathogenesis—A review in a rodent model
Sanches, Bruno D. A.; Carvalho, Hernandes F. ; Maldarine, Juliana S. ; Biancardi, Manoel F. ; Santos, Fernanda C. A. ; Vilamaior, Patricia S. L. ; Taboga, Sebastião R. (Cell Biology International, 2019) [Resenha]
The prostate is a gland that is not exclusively present in males, being also found in females of several mammalian species, including humans. There is evidence that the prostate in both sexes is affected by the same ... -
Prenatal exposure to finasteride promotes sex-specific changes in gerbil prostate development
; ; Cabral, Ágata S.; Lima, Maria L. D. ; Guerra, Luiz H. A. ; Baraldi, Carolina M. B. ; Calmon, Marília F. ; Rahal, Paula ; Góes, Rejane M. ; Vilamaior, Patricia S. L. et al. (Reproduction, Fertility and Development, 2019) [Artigo]
Finasteride is a drug that is widely used in the treatment of benign prostatic hyperplasia, hair loss and even as a chemotherapeutic agent in the treatment of prostatic adenocarcinoma. However, its use is known to cause ... -
The comet assay in Ceraeochrysa claveri (Neuroptera: Chrysopidae): A suitable approach for detecting somatic and germ cell genotoxicity induced by agrochemicals
Gastelbondo-Pastrana, Bertha Irina; Fernandes, Fábio Henrique ; Salvadori, Daisy Maria Fávero ; Santos, Daniela Carvalho dos (Chemosphere, 2019) [Artigo]
Some agrochemicals are genotoxic to several organisms. Nevertheless, few protocols are currently available for measuring the toxicogenetic effects of these compounds in target and non-target field-collected species of ... -
Short-term exposure to chrysin promotes proliferative responses in the ventral male prostate and female prostate of adult gerbils
Campos, Mônica S.; ; ; Regasini, Luis O. ; ; ; Taboga, Sebastião R. ; (International Journal of Experimental Pathology, 2019) [Artigo]
Chrysin (5,7-dihydroxyflavone) is a bioactive compound found in different fruits, vegetables, honey and propolis. This flavone has been suggested for the treatment of reproductive dysfunction, mainly because of its antioxidant ... -
Characterisation and origins of melanin-concentrating hormone immunoreactive fibres of the posterior lobe of the pituitary and median eminence during lactation in the Long-Evans rat
; ; ; ; ; ; ; de-Moraes Machado, Carla; Horta-Júnior, José A. C. ; (Journal of Neuroendocrinology, 2019) [Artigo]
Although the melanin-concentrating hormone (MCH) and its coding mRNA are predominantly found in the tuberal hypothalamus, there is detectable synthesis of MCH in the preoptic hypothalamus exclusively in lactating dams, ... -
Glycoprotein hormone receptor knockdown leads to reduced reproductive success in male Aedes aegypti
; Garcia, Ana S.G.; Scudeler, Elton L. ; Dos Santos, Daniela C. ; Nóbrega, Rafael H. ; (Frontiers in Physiology, 2019) [Artigo]
Glycoprotein hormone receptors mediate a diverse range of physiological functions in vertebrate and invertebrate organisms. The heterodimeric glycoprotein hormone GPA2/GPB5 and its receptor LGR1, constitute a recently ... -
Autophagy and vacuolar biogenesis during the nectary development
Machado, Silvia R.; Rodrigues, Tatiane M. (Planta, 2019) [Artigo]
Main conclusion: Different autophagy pathways are a driver of vacuolar biogenesis and are development stage specific during the extrafloral nectary development in Citharexylum myrianthum. Abstract: Plant autophagy plays ... -
Cobalt-chromium-enriched medium ameliorates shear-stressed endothelial cell performance
Machado, Mariana Issler Pinheiro; Gomes, Anderson Moreira ; Rodrigues, Marcel Ferreira ; Silva Pinto, Thais ; da Costa Fernandes, Célio Júnior ; Bezerra, Fábio J. ; Zambuzzi, Willian Fernando (Journal of Trace Elements in Medicine and Biology, 2019) [Artigo]
Angiogenesis is a relevant mechanism to be considered for the success of bone healing, even considering endosseous implantable devices, providing adequate delivery of substances necessaries for the cell viability and bone ... -
Differential inflammatory landscape stimulus during titanium surfaces obtained osteogenic phenotype
da S. Feltran, Georgia; Bezerra, Fábio ; da Costa Fernandes, Célio Júnior ; Ferreira, Marcel Rodrigues ; Zambuzzi, Willian F. (Journal of Biomedical Materials Research - Part A, 2019) [Artigo]
Molecular mechanism governing inflammatory scenario in response to titanium (Ti)-nanotexturing surfaces needs to be better addressed. Thus, we subjected pre-osteoblast to different Ti-texturing surfaces, as follows: machined ... -
Negative impact of Novaluron on the nontarget insect Bombyx mori (Lepidoptera: Bombycidae)
Santorum, Marilucia; ; ; Padovani, Carlos Roberto ; ; dos Santos, Daniela Carvalho (Environmental Pollution, 2019) [Artigo]
Due to increased use of agrochemicals and growing concerns about ecotoxicology, the development of new insecticides, moving away from those with neurotoxic and broad spectrum effects towards insecticides that are safer for ... -
“Prostate telocytes change their phenotype in response to castration or testosterone replacement”
Felisbino, Sérgio Luis; ; Delella, Flávia Karina ; Scarano, Wellerson Rodrigo ; ; Vilamaior, Patrícia Simone Leite ; Taboga, Sebastião Roberto ; Justulin, Luis Antônio (Scientific Reports, 2019) [Artigo]
Telocytes are CD34-positive cells with a fusiform cell body and long, thin cytoplasmic projections called telopodes. These cells were detected in the stroma of various organs, including the prostate. The prostate is a ... -
Bisphenol-S promotes endocrine-disrupting effects similar to those promoted by bisphenol-A in the prostate of adult gerbils
; ; ; ; ; ; Taboga, Sebastião Roberto; ; ; (Reproductive Toxicology, 2019) [Artigo]
This study evaluated the effects of BPS (40 μg/kg/day, during 28 consecutive days) on the male ventral prostate and female prostate of adult gerbils. For comparative purposes, gerbils were also exposed to BPA under the ... -
Aluminum disrupts the prenatal development of the male and female gerbil prostate (Meriones unguiculatus)
; ; ; ; ; Taboga, Sebastião R.; ; (Experimental and Molecular Pathology, 2019) [Artigo]
Normal prostate development is highly dependent of an equilibrated hormonal regulation, so that sensible interferences during this period may predispose the gland to lesions during aging. Industrial activities have increased ... -
Pest and natural enemy: how the fat bodies of both the southern armyworm Spodoptera eridania and the predator Ceraeochrysa claveri react to azadirachtin exposure
Scudeler, Elton Luiz; Garcia, Ana Silvia Gimenes ; Padovani, Carlos Roberto ; dos Santos, Daniela Carvalho (Protoplasma, 2019) [Artigo]
The effects of biopesticides on insects can be demonstrated by morphological and ultrastructural tools in ecotoxicological analysis. Azadirachtin-based products are widely used as biopesticides, affecting numerous insect ... -
c-Src kinase contributes on endothelial cells mechanotransduction in a heat shock protein 70-dependent turnover manner
Pinto, Thaís Silva; Fernandes, Célio Junior da Costa ; da Silva, Rodrigo Augusto ; Gomes, Anderson Moreira ; Vieira, José Cavalcante Souza ; Padilha, Pedro de M. ; Zambuzzi, Willian F. (Journal of Cellular Physiology, 2019) [Artigo]
Shear stress changes are associated with a repertory of signaling cascade modulating vascular phenotype. As shear stress-related tensional forces might be associated with pathophysiological susceptibility, a more comprehensive ... -
Can exposure to neem oil affect the spermatogenesis of predator Ceraeochrysa claveri?
Garcia, Ana Silvia Gimenes; Scudeler, Elton Luiz ; Pinheiro, Patricia Fernanda Felipe ; dos Santos, Daniela Carvalho (Protoplasma, 2019) [Artigo]
Novel biological control methods and integrated pest management strategies are basic requirements for the development of sustainable agriculture. As a result, there is a growing demand for research on the use of plant ... -
The role of triiodothyronine hormone and mechanically-stressed endothelial cell paracrine signalling synergism in gene reprogramming during hBMSC-stimulated osteogenic phenotype in vitro
da Silva, Rodrigo A.; de Camargo Andrade, Amanda Fantini ; da Silva Feltran, Geórgia ; Fernandes, Célio Júnior da C. ; ; Ferreira, Marcel Rodrigues ; ; Zambuzzi, Willian F. (Molecular and Cellular Endocrinology, 2018) [Artigo]
We therefore investigated whether there is synergism between triiodothyronine (T3) hormone and trophic molecules released from mechanically-stressed endothelial cells (EC-enriched medium) in osteogenic phenotype by mapping ... -
Laminar shear stress-provoked cytoskeletal changes are mediated by epigenetic reprogramming of TIMP1 in human primary smooth muscle cells
da Silva, Rodrigo A.; Fernandes, Célio Jr da C. ; Feltran, Geórgia da S. ; Gomes, Anderson M. ; de Camargo Andrade, Amanda Fantini ; ; ; Zambuzzi, Willian F. (Journal of Cellular Physiology, 2019) [Artigo]
Whereas endothelial responses to shear stress are well-characterized, the cell physiological effects of shear stress in smooth muscle cells (SMCs) remain largely obscure. As SMCs are directly challenged by shear stress ... -
Comparative Proteomics of Methicillin-Resistant Staphylococcus aureus Subjected to Synergistic Effects of the Lantibiotic Nisin and Oxacillin
Bergamo Alves, Fernanda Cristina; Albano, Mariana ; Murbach Teles Andrade, Bruna Fernanda ; Chechi, Jessica Luana ; Marques Pereira, Ana Flavia ; Furlanetto, Alessandra ; Mores Rall, Vera Lucia ; Henrique Fernandes, Ana Angelica ; Santos, Lucilene Delazari dos ; et al. (Microbial Drug Resistance, 2019) [Artigo]
We investigated the responses and mechanisms of action of methicillin-resistant Staphylococcus aureus (MRSA) metabolism when exposed under sublethal concentrations of the synergistic antibacterial combination of nisin + ...