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dc.contributor.authorGarbino, J. A.
dc.contributor.authorNaafs, B. [UNESP]
dc.contributor.authorUra, S.
dc.contributor.authorSalgado, M. H. [UNESP]
dc.contributor.authorVirmond, M.
dc.date.accessioned2014-05-20T13:27:07Z
dc.date.available2014-05-20T13:27:07Z
dc.date.issued2010-09-01
dc.identifierhttp://go.galegroup.com/ps/i.do?id=GALE%7CA317779687&v=2.1&u=capes58&it=r&p=AONE&sw=w
dc.identifier.citationLeprosy Review. Colchester: Lepra, v. 81, n. 3, p. 206-215, 2010.
dc.identifier.issn0305-7518
dc.identifier.urihttp://hdl.handle.net/11449/8841
dc.description.abstractBackground: Leprosy neuropathy, despite being primarily demyelinating, frequently leads to axonal loss. Neurophysiological examination of the nerves during Type 1 (T1R) and Type 2 reactions (T2R) may give some insight into the pathophysiological mechanisms.Methods: Neurophysiological examinations were performed in 28 ulnar nerves during a clinical trial of steroid treatment effectiveness, 19 patients with T1R and nine with T2R. The nerves were monitored during a period of 6 months; there were eight assessments per nerve, for a total of 224 assessments. Nine neurophysiological parameters were assessed at three sites of the ulnar nerve. The compound motor action potential amplitudes elicited at wrist, elbow and above, as well as the conduction velocity and temporal dispersion across the elbow, were chosen to focus on the changes occurring in the parameters at the elbow tunnel.Results and Conclusion: Neurophysiological changes indicating axonal and demyelinating processes during both T1R and T2R were detected across the elbow. Changes in demyelination, i.e. a Conduction Block, as a primary event present during T2R, occurring as an acute phenomenon, were observed regularly; in T1R Temporal Dispersion, a subacute phenomenon, was seen. During treatment remyelination occurred after both types of reactions.en
dc.format.extent206-215
dc.language.isoeng
dc.publisherLepra
dc.relation.ispartofLeprosy Review
dc.sourceWeb of Science
dc.titleNeurophysiological patterns of ulnar nerve neuropathy in leprosy reactionsen
dc.typeArtigo
dcterms.rightsHolderLepra
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionFdn Dermatol & Venereol Polderma
dc.contributor.institutionRDTC
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.description.affiliationInst Lauro de Souza Lima, Bauru, SP, Brazil
dc.description.affiliationFdn Dermatol & Venereol Polderma, Emmeloord, Netherlands
dc.description.affiliationRDTC, Moshi, Tanzania
dc.description.affiliationUNESP, Dept Engn, Bauru, SP, Brazil
dc.description.affiliationUnespUNESP, Dept Engn, Bauru, SP, Brazil
dc.identifier.wosWOS:000298266700006
dc.rights.accessRightsAcesso aberto
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Engenharia, Baurupt
dc.identifier.lattes8207092389931188
unesp.author.lattes8207092389931188
dc.relation.ispartofjcr0.752
dc.relation.ispartofsjr0,563
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