Efeitos cardiovasculares e respiratórios da infusão contínua ne naloxona ou tramadol, em coelhos anestesiados com isofluorano e submetidos à hipovolemia aguda
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Data
2009-12-02
Autores
Moro, Juliana Vitti [UNESP]
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Universidade Estadual Paulista (Unesp)
Resumo
Para avaliar os efeitos da infusão contínua de naloxona ou tramadol sobre a resposta à hipovolemia aguda foram utilizados 40 coelhos adultos distribuídos em cinco grupos: grupo naloxona (GN), grupo tramadol 1 (GT1), grupo tramadol 3 (GT3), grupo tramadol 5 (GT5) e grupo controle (GC). Os animais foram induzidos (2,5 CAM) e mantidos (1,5 CAM) à anestesia com isofluorano e após 60 minutos receberam bolus de solução de NaCl a 0,9% (GC), de naloxona (GN) ou de diferentes doses de tramadol (GT1, GT3 e GT5), seguido de infusão contínua dos mesmos fármacos. Decorridos dez minutos, os coelhos foram induzidos à hipovolemia por meio da retirada de sangue arterial no volume total de 15 ml/kg, o qual foi reinfundido após uma hora. Os parâmetros avaliados foram frequência cardíaca, eletrocardiografia, pressão venosa central, pressões arteriais (PA), pressão de perfusão coronariana (PPC), frequência respiratória, saturação de oxiemoglobina e tensão parcial de dióxido de carbono ao final da expiração. Os dados foram submetidos à análise de variância seguida pelo teste de Tukey (p<0,05). Houve diminuição significativa das médias de PA e PPC após a retirada sanguínea, em todos os grupos, com posterior retorno aos valores iniciais durante a reinfusão do sangue, com exceção do GT5 que apresentou médias estáveis durante a hipovolemia e reinfusão. O GC e GT1 apresentaram médias de PA e PPC menores que as do GT5 vinte minutos após a remoção sanguínea. As demais variáveis não apresentaram diferença significativa ao longo do período experimental. Concluiu-se que a administração do tramadol, na dose de 5 mg/kg seguida por infusão contínua de 0,025 mg/kg/min, é indicada na terapia da hipovolemia aguda, pois possui ações benéficas na PA e na PPC, sem alterar os demais parâmetros estudados.
To evaluate the effects of continuous infusion of naloxone or tramadol on the answer to acute hypovolemia, forty adult rabbits were assigned into five groups: naloxone group (NG), tramadol group 1 (TG1), tramadol group 3 (TG3), tramadol group 5 (TG5) and control group (CG). General anesthesia was induced (2.5 CAM) and maintained (1.5 CAM) with isoflurane and, after sixty minutes, the bolus of NaCl to 0.9% (CG), of naloxone (NG) or the several doses of tramadol (TG1, TG3 e TG5) followed by continuous infusion of the same drugs were administered. After 10 minutes, the rabbits were induced to hypovolemia by withdrawing arterial blood in total volume of 15 ml/kg, which was reinfused after one hour. Heart rate, electrocardiogram, venous central pressure, arterial pressures (AP), coronary perfusion pressure (CPP), respiratory rate, pulse oxygen saturation and end-tidal carbon dioxide were evaluated. Numerical data were submitted to analyses of variance followed by Tukey test (p<0.05). The AP and CPP decreased significantly, after blood withdrawal, in all groups. During blood reinfusion, these parameters came back to the initial values, except in TG5, because these variables were stable during hypovolemia and blood reinfusion. The CG and TG1 showed mean of AP and CPP lower than the TG5 at twenty minutes after the withdrawal of blood. It was concluded that tramadol administration, at dose of 5 mg/kg followed by continuous infusion of 0.025 mg/kg/min, is indicated in therapy of acute hypovolemia, because it has useful action on AP and on CPP, besides this drug does not impair the other evaluated parameters.
To evaluate the effects of continuous infusion of naloxone or tramadol on the answer to acute hypovolemia, forty adult rabbits were assigned into five groups: naloxone group (NG), tramadol group 1 (TG1), tramadol group 3 (TG3), tramadol group 5 (TG5) and control group (CG). General anesthesia was induced (2.5 CAM) and maintained (1.5 CAM) with isoflurane and, after sixty minutes, the bolus of NaCl to 0.9% (CG), of naloxone (NG) or the several doses of tramadol (TG1, TG3 e TG5) followed by continuous infusion of the same drugs were administered. After 10 minutes, the rabbits were induced to hypovolemia by withdrawing arterial blood in total volume of 15 ml/kg, which was reinfused after one hour. Heart rate, electrocardiogram, venous central pressure, arterial pressures (AP), coronary perfusion pressure (CPP), respiratory rate, pulse oxygen saturation and end-tidal carbon dioxide were evaluated. Numerical data were submitted to analyses of variance followed by Tukey test (p<0.05). The AP and CPP decreased significantly, after blood withdrawal, in all groups. During blood reinfusion, these parameters came back to the initial values, except in TG5, because these variables were stable during hypovolemia and blood reinfusion. The CG and TG1 showed mean of AP and CPP lower than the TG5 at twenty minutes after the withdrawal of blood. It was concluded that tramadol administration, at dose of 5 mg/kg followed by continuous infusion of 0.025 mg/kg/min, is indicated in therapy of acute hypovolemia, because it has useful action on AP and on CPP, besides this drug does not impair the other evaluated parameters.
Descrição
Palavras-chave
Anesthetic agent, Arterial pressure, Blood reinfusion, opioids, Coelho, Anestesia veterinaria, Pressão arterial, Opióides, Agente anestésico, Reinfusão sanguinea
Como citar
MORO, Juliana Vitti. Efeitos cardiovasculares e respiratórios da infusão contínua ne naloxona ou tramadol, em coelhos anestesiados com isofluorano e submetidos à hipovolemia aguda. 2009. xvii, 57 f. Dissertação (mestrado) - Universidade Estadual Paulista, Faculdade de Ciências Agrárias e Veterinárias, 2009.