Efeitos da sinvastatina na prenhez de ratas
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Data
2011-07-07
Autores
Castro, Maria José Domingues de [UNESP]
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Editor
Universidade Estadual Paulista (Unesp)
Resumo
Devido ao aumento na taxa de óbitos relacionados à aterosclerose e AVC a sinvastatina tornou-se o medicamento eleito pelo SUS, por sua eficácia no combate às altas taxas de colesterol plasmático e diabete melitos. Enfermidades estas, decorrentes tanto de histórico familiar de hipercolesterolemia, quanto devido a hábitos de vida sedentária e de alimentação desregrada, que vem acometendo adultos jovens e mulheres em idade fértil; que já fazem uso de um ou mais medicamentos. Associado às vezes a uma gravidez não planejada, afetando também o feto. Inúmeros trabalhos têm sido feitos com o intuito de conhecer melhor sobre a atuação desse fármaco utilizado durante o período gestacional, tanto que, diversos medicamentos em princípio são contra indicados, principalmente nos primeiros três meses. Entretanto a sinvastatina, embora controversa a sua contra indicação, é o fármaco de escolha nos postos de saúde e essas jóvens mulheres grávidas estão fazendo uso dos mesmos. O objetivo desse trabalho foi o de fornecer maior embasamento a essa contra indicação. Foram utilizadas 24 ratas em período gestacional, onde desde o primeiro dia da prenhez confirmada as mesmas receberam por gavagem o fármaco manipulado pela farmácia de manipulação “A Especialista”. Os animais foram divididos em 4 grupos: as ratas controle, que receberam óleo de amêndoas doce e as ratas que receberam 10, 20 e 40 mg/kg de sinvastatina diariamente. Os resultados foram plotados em planilhas do Excel e submetidos aos testes estatísticos não paramétricos e serviram para corroborar a contra indicação do fármaco pois houve aumento significativo do número de reabsorções fetais nos cornos uterinos comprometendo a prenhez, reduzindo o número de fetos gerados nas ratas que receberam 40 mg/kg, além de diminuir o peso e comprimento dos fetos em geral
Simvastatin is currently the medicine chosen actually due to hight atherosclerosis death index and its effectiveness in combating high rates of plasma cholesterol and diabetes mellitus. Diseases caused both by family histories of hypercholesterolemia as well, due to sedentary lifestyles and eating disorders, which are affecting young adults and women of childbearing age who, due to this family history, had used one or more drugs which interact intensifying their effect, .associated some times to, an unplanned pregnancy, and drug interaction, affecting both. Several studies have been done in order to learn and get better foundation about the actions of these drugs during pregnancy, so that several medications, in principle, are contraindicated. However simvastatin, controversial contraindication, is the choosen drug in health care, and those pregnant women with a family history of hypercholesterolemia are making use of them. Therefore, the purpose of this study is to confirm this contraindication. The sample consisted of 24 female rats with confirmed pregnancy from day one. The entire sample received by gavage the drug - manipulated by the Specialist pharmacy. The animals were divided into four groups: 1. control (SC), where the rats received sweet almond oil and three other groups (S10, S20 and S40) where the rats received simvastatin 10, 20 and 40 mg / kg daily, respectively. The results were plotted in an excel spreadsheet and submitted to a nonparametric statistical test. They served to confirm our initial goal confirming the simvastatin contraindication drug due to uterin reabsortion increased number reducing little rats number, wheight and size. Thus compromising pregnancy
Simvastatin is currently the medicine chosen actually due to hight atherosclerosis death index and its effectiveness in combating high rates of plasma cholesterol and diabetes mellitus. Diseases caused both by family histories of hypercholesterolemia as well, due to sedentary lifestyles and eating disorders, which are affecting young adults and women of childbearing age who, due to this family history, had used one or more drugs which interact intensifying their effect, .associated some times to, an unplanned pregnancy, and drug interaction, affecting both. Several studies have been done in order to learn and get better foundation about the actions of these drugs during pregnancy, so that several medications, in principle, are contraindicated. However simvastatin, controversial contraindication, is the choosen drug in health care, and those pregnant women with a family history of hypercholesterolemia are making use of them. Therefore, the purpose of this study is to confirm this contraindication. The sample consisted of 24 female rats with confirmed pregnancy from day one. The entire sample received by gavage the drug - manipulated by the Specialist pharmacy. The animals were divided into four groups: 1. control (SC), where the rats received sweet almond oil and three other groups (S10, S20 and S40) where the rats received simvastatin 10, 20 and 40 mg / kg daily, respectively. The results were plotted in an excel spreadsheet and submitted to a nonparametric statistical test. They served to confirm our initial goal confirming the simvastatin contraindication drug due to uterin reabsortion increased number reducing little rats number, wheight and size. Thus compromising pregnancy
Descrição
Palavras-chave
Sinvastatina - Efeitos na gravidez, Simvastatin - Effects on pregnancy
Como citar
CASTRO, Maria José Domingues de. Efeitos da sinvastatina na prenhez de ratas. 2011. 45 f. Dissertação (mestrado) – Universidade Estadual Paulista, Faculdade de Odontologia de São José dos Campos., 2011.