Toxicity and effect of whitening toothpastes on enamel surface

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dc.contributor.authorde Mello Rode, Sigmar [UNESP]
dc.contributor.authordo Prado Sato, Tabata [UNESP]
dc.contributor.authorde Souza Matos, Felipe
dc.contributor.authorde Oliveira Correia, Ayla Macyelle [UNESP]
dc.contributor.authorCamargo, Samira Esteves Afonso
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal de Uberlândia (UFU)
dc.contributor.institutionCollege of Dentistry
dc.date.accessioned2021-06-25T10:26:13Z
dc.date.available2021-06-25T10:26:13Z
dc.date.issued2021-01-01
dc.description.abstractThis in vitro study evaluated the biocompatibility and abrasivity of whitening and conventional toothpastes. Samples of conventional (non-whitening) - Edel White Infant (EWI) - and whitening toothpastes - Edel White Whitening (EWW), Edel White CAREFORTE (EWC), Colgate Total 12Ò Professional (C), and Oral-B Whitening (OB) - were dissolved in culture medium (0.2 g sample weight per mL). Human gingival fibroblasts (hGF) were placed in contact with different dilutions of culture media that had been previously exposed to these toothpastes. Cytotoxicity was then assessed using the methyl tetrazolium test (MTT) and the cell survival rate was determined. Genotoxicity was assessed by the micronucleus test (MNT) and the number of micronuclei was determined before and after exposure to the toothpaste solutions. The enamel surface roughness was evaluated in specimens of bovine teeth (n = 10 per group) before and after 10,000 brushing cycles, using the investigated toothpastes. The results were statistically analyzed using the Mann-Whitney U test and two-way ANOVA (p<0.05). According to the MTT assay, EWW and OB presented significant cytotoxicity (p<0.01), but no genotoxic (MNT) effects (p > 0.05). C toothpaste was statistically significantly abrasive to the enamel surface (p<0.01). The findings of this study may be helpful for individualized selection of commercial toothpastes, as some whitening toothpastes present significant cytotoxicity and conventional toothpaste cause significant surface changes.en
dc.description.affiliationUniversidade Estadual Paulista – Unesp Institute of Science and Technology Department of Dental Materials
dc.description.affiliationUniversidade Federal de Uberlândia – UFU School of Dentistry Postgraduate Program in Dentistry
dc.description.affiliationUniversidade Estadual Paulista – Unesp Institute of Science and Technology Department of Restorative Dentistry
dc.description.affiliationUniversity of Florida College of Dentistry Department of Restorative Dental Sciences
dc.description.affiliationUnespUniversidade Estadual Paulista – Unesp Institute of Science and Technology Department of Dental Materials
dc.description.affiliationUnespUniversidade Estadual Paulista – Unesp Institute of Science and Technology Department of Restorative Dentistry
dc.format.extent1-7
dc.identifierhttp://dx.doi.org/10.1590/1807-3107BOR-2021.VOL35.0025
dc.identifier.citationBrazilian Oral Research, v. 35, p. 1-7.
dc.identifier.doi10.1590/1807-3107BOR-2021.VOL35.0025
dc.identifier.issn1807-3107
dc.identifier.issn1806-8324
dc.identifier.scopus2-s2.0-85102828350
dc.identifier.urihttp://hdl.handle.net/11449/206077
dc.language.isoeng
dc.relation.ispartofBrazilian Oral Research
dc.sourceScopus
dc.subjectTooth Bleaching Agents
dc.subjectTooth Wear
dc.subjectToothpastes
dc.titleToxicity and effect of whitening toothpastes on enamel surfaceen
dc.typeArtigo

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