N,N,N-trimethyl chitosan nanoparticles as a vitamin carrier system

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dc.contributor.authorde Britto, Douglas
dc.contributor.authorde Moura, Márcia R.
dc.contributor.authorAouada, Fauze A. [UNESP]
dc.contributor.authorMattoso, Luiz H. C.
dc.contributor.authorAssis, Odílio B.G.
dc.contributor.institutionEmpresa Brasileira de Pesquisa Agropecuária (EMBRAPA)
dc.contributor.institutionInstituto de Física de São Carlos
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:26:31Z
dc.date.available2014-05-27T11:26:31Z
dc.date.issued2012-06-01
dc.description.abstractThere is considerable interest in incorporating stabilized vitamins into biopolymeric nanoparticles, especially in the development of carriers and active systems for pharmaceutical and food applications. Amongst biopolymer, chitosan is highly desirable owing to its good biocompatibility, biodegradability and ability to be chemically modified. In this paper, nanoparticles from three kinds of water-soluble derivative chitosan (N,N,N-trimethyl chitosan, TMC) have successfully been synthesized by ionic gelation with tripolyphosphate (TPP) anions. Combinations of concentrations of TMC and TPP have resulted in nanoparticles with varying sizes for which the capability for loading with vitamins was investigated. Zeta potential measurement and particle size analysis demonstrated that the size of the nanoparticles wasoptimized (196±8nm) when the lowest TMC and TPP amounts were used, i.e., 0.86mgmL -1 and 0.114mgmL -1 respectively. As the TMC and/or the TPP concentrations increase, the resulting size of the nanoparticles increases considerably. Three different vitamins (B9, B12 and C) were tested as additives and the final system characterized in relation to size, morphology, spectroscopic and zeta potential properties. In general, the incorporation of vitamins increased all the TMC-TPP original nanoparticle sizes, reaching a maximum diameter of 534±20nm when loaded with vitamin C. The presence of vitamins also decreases the zeta potential, with one exception observed when using vitamin C. The preliminary results of this study suggested that all TMC/TPP nanoparticles can be successfully used as a stable medium to incorporate and transport vitamins, with potential applications in foodstuffs. © 2011 Elsevier Ltd.en
dc.description.affiliationLaboratório Nacional de Nanotecnologia para o Agronegócio (LNNA) Embrapa Instrumentação, R. XV de Novembro, 1452, São Carlos, SP 13560-905
dc.description.affiliationLaboratório de Nanomedicina e Nanotoxicologia (LNN) Instituto de Física de São Carlos, Av. Trabalhador São-carlense, 400, São Carlos, SP 13560-970
dc.description.affiliationInstituto de Química UNESP, R. Francisco Degni, s/n, Bairro Quitandinha, Araraquara, SP 14800-900
dc.description.affiliationUnespInstituto de Química UNESP, R. Francisco Degni, s/n, Bairro Quitandinha, Araraquara, SP 14800-900
dc.format.extent487-493
dc.identifierhttp://dx.doi.org/10.1016/j.foodhyd.2011.09.002
dc.identifier.citationFood Hydrocolloids, v. 27, n. 2, p. 487-493, 2012.
dc.identifier.doi10.1016/j.foodhyd.2011.09.002
dc.identifier.issn0268-005X
dc.identifier.scopus2-s2.0-84855198514
dc.identifier.urihttp://hdl.handle.net/11449/73343
dc.language.isoeng
dc.relation.ispartofFood Hydrocolloids
dc.relation.ispartofjcr5.089
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectIonotropic gelation
dc.subjectMorphologic properties
dc.subjectSpectroscopic characterization
dc.subjectTrimethyl chitosan-TPP nanoparticles
dc.subjectVitamin incorporation
dc.titleN,N,N-trimethyl chitosan nanoparticles as a vitamin carrier systemen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy

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