DEVELOPMENT AND VALIDATION OF METHODS USING DERIVATIVE SPECTRO-PHOTOMETRY FOR DETERMINATION OF DIPYRONE IN PHARMACEUTICAL FORMULATIONS

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dc.contributor.authorCosta Lopes, Francisco das Chagas da
dc.contributor.authorFonseca, Lorenna
dc.contributor.authorMoita, Graziella Ciaramella
dc.contributor.authorMoura Ribeiro, Marcos Vinicius de [UNESP]
dc.contributor.institutionUniv Fed Piaui
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-11-26T16:01:24Z
dc.date.available2018-11-26T16:01:24Z
dc.date.issued2018-06-01
dc.description.abstractDipyrone (sodium noramidopyrine methanesulfate), a member of the pyrazolone group, is a drug that possesses analgesic, antipyretic, anti-inflammatory, and spasmolytic properties. Traditionally, iodimetric methods have been recommended for the quantitative determination of dipyrone in all its pharmaceutical forms. This work describes the development of zero order and fourth order (Delta lambda = 10) derivative spectrophotometric methods for the determination of dipyrone in different pharmaceutical formulations, using water as solvent. The analytical curves presented correlation coefficients greater than 0.999, limits of detection varying from 0.23 to 0.49 mg L-1, and limits of quantification varying from 0.78 to 1.63 mg L-1. The average recoveries ranged from 98 to 103 % for the zero order method and from 96 to 104 % for third and fourth order derivative methods. Intra and inter-day precisions, expressed as relative standard deviations, were below 4.2 %. The excipients present in dipyrone tablets and solutions did not interfere in the analyses. The method was shown to be linear, reproducible, specific, sensitive and rugged.en
dc.description.affiliationUniv Fed Piaui, Nat Sci Ctr, Dept Chem, Teresina, PI, Brazil
dc.description.affiliationSao Paulo State Univ UNESP, Inst Chem, Araraquara, SP, Brazil
dc.description.affiliationUnespSao Paulo State Univ UNESP, Inst Chem, Araraquara, SP, Brazil
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent2201-2210
dc.identifierhttp://dx.doi.org/10.13040/IJPSR.0975-8232.9(6).2201-10
dc.identifier.citationInternational Journal Of Pharmaceutical Sciences And Research. Haryana: Int Journal Pharmaceutical Sciences & Research, v. 9, n. 6, p. 2201-2210, 2018.
dc.identifier.doi10.13040/IJPSR.0975-8232.9(6).2201-10
dc.identifier.issn0975-8232
dc.identifier.urihttp://hdl.handle.net/11449/160331
dc.identifier.wosWOS:000434063900007
dc.language.isoeng
dc.publisherInt Journal Pharmaceutical Sciences & Research
dc.relation.ispartofInternational Journal Of Pharmaceutical Sciences And Research
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectDipyrone
dc.subjectderivative Spectrophotometry
dc.subjectValidation
dc.subjectPharmaceutical formulations
dc.titleDEVELOPMENT AND VALIDATION OF METHODS USING DERIVATIVE SPECTRO-PHOTOMETRY FOR DETERMINATION OF DIPYRONE IN PHARMACEUTICAL FORMULATIONSen
dc.typeArtigo
dcterms.rightsHolderInt Journal Pharmaceutical Sciences & Research

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