Gastroprotective activity of Pradosia huberi on experimentally induced gastric lesions in rodents: Role of endogenous sulphydryls and nitric oxide

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dc.contributor.authorKushima, W.
dc.contributor.authorHiruma-Lima, C. A.
dc.contributor.authorSantos, M. A.
dc.contributor.authorViana, E.
dc.contributor.authorCoelho-Ferreira, M.
dc.contributor.authorBrito, ARMS
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionIEPA
dc.contributor.institutionMuseu Paraense Emilio Goeldi
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.date.accessioned2014-05-20T15:21:43Z
dc.date.available2014-05-20T15:21:43Z
dc.date.issued2005-10-03
dc.description.abstractPradosia huberi is a medicinal plant very common in the Amazonian forest population. The research interest in this plant is justifiable because of its potential medicinal value in gastritis and gastric ulcer mentioned in local folk medicine. In this paper, we evaluated the acute toxicity and antiulcerogenic effect of a hydroalcoholic extract (HAE) obtained from Pradosia huberi barks in rodents. No acute toxicological sign or symptom was observed in animals treated with the highest dose (5000 mg/kg, p.o.) of Pradosia huberi. In the HCl/EtOH-induced gastric ulcer model, HAE demonstrated significant inhibition of the ulcerative lesion index by 73% (500 mg/kg) and 88% (1000 mg/kg), respectively, in relation to the control value (p < 0.05). The gastric damage induced by absolute ethanol in rats was effectively reduced by 84, 88 and 81% (250, 500 and 1000 mg/kg) when compared with the control group (p < 0.01). In the NSAID-induced lesion model, HAE also showed antiulcerogenic effect with decrease in gastric lesions of 56% (250 mg/kg), 57% (500 mg/kg) and 67% (1000 mg/kg) when compared with animals treated with vehicle (p < 0.05). In the gastric ulcer induced by pylorus ligature model, the administration of HAE by oral and intraduodenal routes inhibited the gastric lesion index by 79 and 52% (500 mg/kg), respectively. HAE administered orally or intraduodenally was able to change gastric juice parameters (pH, volume and acid output) as well as those treated with cimetidine. The treatment with HAE (p.o.) significantly increased gastric volume, the pH values and promoted reduced acid output (1) < 0.01). By comparative effect (intraduodenal and oral route), we observed that HAE was better for local activity in gastric mucosa than in systemic action. HAE also has a non-specific activity when found to be the inhibitor of intestinal motility (p > 0.01). The mechanism of action of HAE did not seem to be related to the NO-inhibitor but showed the participation of endogenous sulphydryl group in the gastroprotective action. (C) 2005 Elsevier B.V.. All rights reserved.en
dc.description.affiliationUniv Estadual Paulista, Inst Biociencias, Dept Fisiol, BR-18608000 São Paulo, Brazil
dc.description.affiliationIEPA, Inst Pesquisas Cient & Tecnol Amapa, BR-68900260 Macapa, Amapa, Brazil
dc.description.affiliationMuseu Paraense Emilio Goeldi, Coordenacao Bot, BR-66077530 Belem, Para, Brazil
dc.description.affiliationUniv Estadual Campinas, Inst Biol, Dept Fisiol & Biofis, BR-13083970 Campinas, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Inst Biociencias, Dept Fisiol, BR-18608000 São Paulo, Brazil
dc.format.extent61-67
dc.identifierhttp://dx.doi.org/10.1016/j.jep.2005.03.014
dc.identifier.citationJournal of Ethnopharmacology. Clare: Elsevier B.V., v. 101, n. 1-3, p. 61-67, 2005.
dc.identifier.doi10.1016/j.jep.2005.03.014
dc.identifier.issn0378-8741
dc.identifier.lattes3814504901386844
dc.identifier.orcid0000-0002-8645-3777
dc.identifier.urihttp://hdl.handle.net/11449/32831
dc.identifier.wosWOS:000232312200009
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofJournal of Ethnopharmacology
dc.relation.ispartofjcr3.115
dc.relation.ispartofsjr1,150
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectPradosia hubeript
dc.subjectantiulcerogenic activitypt
dc.subjectendogenous sulphydrylspt
dc.subjectAmazon forestpt
dc.titleGastroprotective activity of Pradosia huberi on experimentally induced gastric lesions in rodents: Role of endogenous sulphydryls and nitric oxideen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes3814504901386844[2]
unesp.author.orcid0000-0002-8645-3777[2]

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