Altered plasma response to zinc and iron tolerance test after Roux-en-Y gastric bypass

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dc.contributor.authorRosa, Flavia Troncon [UNESP]
dc.contributor.authorde Oliveira-Penaforte, Fernanda Rodrigues
dc.contributor.authorLeme, Izabel de Arruda
dc.contributor.authorPadovan, Gilberto Joao
dc.contributor.authorCeneviva, Reginald
dc.contributor.authorMarchini, Julio Sergio [UNESP]
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionTriangulo Mineiro Fed Univ
dc.date.accessioned2014-05-20T13:23:41Z
dc.date.available2014-05-20T13:23:41Z
dc.date.issued2011-05-01
dc.description.abstractBackground: The duodenum and proximal jejunum are excluded after Roux-en-Y gastric bypass but these intestinal sites are where iron and zinc are most absorbed. Therefore, they are among the nutrients whose digestive and absorptive process can be impaired after surgery. The aim of the present study was to investigate the iron and zinc plasma response to a tolerance test before and after bariatric surgery. The study was performed at São Paulo University School of Medicine of Ribeirao Preto, Brazil.Methods: In a longitudinal paired study, 9 morbidly obese women (body mass index >= 40 kg/m(2)) underwent an iron and zinc tolerance test before and 3 months after surgery. The iron and zinc levels were determined at 0, 1, 2, 3, and 4 hours after a physiologic unique oral dose. The mineral concentrations in die plasma and 24-hour urine sample were assayed using an atomic absorption spectrophotometer. The anthropometric measurements and 3-day food record were also evaluated. A linear mixed model was used to compare the plasma concentration versus interval after the oral dose, before and after surgery.Results: The pre- and postoperative test results revealed a significantly lower plasma zinc response (P <.01) and a delayed response to iron intake after surgery. The total plasma iron concentration area, during the 4 hours, was not different after surgery (P >.05). The 24-hour urinary iron and zinc excretion did not differ between the pre- and postoperative phases.Conclusion: The present data showed a compromised response to the zinc tolerance test after gastric bypass surgery, suggesting an impaired absorption of zinc. More attention must be devoted to zinc nutritional status after surgery. (Surg Obes Relat Dis 2011;7:309-314.) (C) 2011 American Society for Metabolic and Bariatric Surgery. All rights reserved.en
dc.description.affiliationUniv São Paulo, Sch Med Ribeirao Preto, Div Med Nutr, Dept Internal Med, BR-14049900 Ribeirao Preto, SP, Brazil
dc.description.affiliationSão Paulo State Univ, Fac Pharmaceut Sci, Dept Food & Nutr, Araraquara, Brazil
dc.description.affiliationTriangulo Mineiro Fed Univ, Uberaba, Brazil
dc.description.affiliationUniv São Paulo, Sch Med Ribeirao Preto, Dept Surg & Anat, BR-14049900 Ribeirao Preto, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ, Fac Pharmaceut Sci, Dept Food & Nutr, Araraquara, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 0552995-0
dc.format.extent309-314
dc.identifierhttp://dx.doi.org/10.1016/j.soard.2011.01.041
dc.identifier.citationSurgery For Obesity and Related Diseases. New York: Elsevier B.V., v. 7, n. 3, p. 309-314, 2011.
dc.identifier.doi10.1016/j.soard.2011.01.041
dc.identifier.issn1550-7289
dc.identifier.urihttp://hdl.handle.net/11449/7194
dc.identifier.wosWOS:000291379000011
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofSurgery For Obesity and Related Diseases
dc.relation.ispartofjcr3.900
dc.relation.ispartofsjr1,242
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectIronen
dc.subjectZincen
dc.subjectTolerance testen
dc.subjectAbsorptionen
dc.subjectObesityen
dc.subjectBariatric surgeryen
dc.subjectNutritionen
dc.titleAltered plasma response to zinc and iron tolerance test after Roux-en-Y gastric bypassen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.departmentAlimentos e Nutrição - FCFpt

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Araraquara - FCF - Faculdade de Ciências Farmacêuticas