Caracterização do complexo de inclusão ropivacaína: β-ciclodextrina

Fraceto, Leonardo Fernandes [UNESP]; Gonçalves, Marcos Moisés; Moraes, Carolina Morales; Araújo, Daniele Ribeiro de; Zanella, Luciana; Paula, Eneida de; Pertinhez, Thelma de Aguiar

Caracterização do complexo de inclusão ropivacaína: β-ciclodextrina

Arquivos

S0100-40422007000500028.pdf (365.96 KB)

Data

2007-10-01

Autores

Fraceto, Leonardo Fernandes

Gonçalves, Marcos Moisés

Moraes, Carolina Morales

Araújo, Daniele Ribeiro de

Zanella, Luciana

Paula, Eneida de

Pertinhez, Thelma de Aguiar

Editor

Sociedade Brasileira de Química

Tipo

Artigo

Direito de acesso

Acesso aberto

Resumo

Characteriza of the inclusion complex ropivacaine: β-cyclodextrin. Ropivacaine (RVC) is a widely used local anesthetic. The complexation of RVC with β-cyclodextrin (β-CD) is of great interest for the development of more efficient local anesthetic formulations. The present work focuses on the characterization of the RVC:β-CD complex by nuclear magnetic resonance (NMR). The stoichiometry of the complex is 1:2 RVC:β-CD. DOSY-NMR shows that the association constant is 55.5 M-1. Longitudinal relaxation time results show that RVC changes its mobility in the presence of β-CD. This study is focused on the physicochemical characterization of inclusion complexes that are potentials options for pain treatment.