Anti-Inflammatory Effect and Toxicological Profile of Pulp Residue from the Caryocar Brasiliense, a Sustainable Raw Material

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dc.contributor.authorFracasso, Julia Amanda Rodrigues [UNESP]
dc.contributor.authorIbe, Mariana Bittencourt [UNESP]
dc.contributor.authorda Costa, Luísa Taynara Silvério [UNESP]
dc.contributor.authorGuarnier, Lucas Pires
dc.contributor.authorViel, Amanda Martins
dc.contributor.authorBrito, Gustavo Reis de [UNESP]
dc.contributor.authorParron, Mariana Conti [UNESP]
dc.contributor.authorPereira, Anderson Espírito do Santo [UNESP]
dc.contributor.authorPegorin Brasil, Giovana Sant’Ana [UNESP]
dc.contributor.authorFarias Ximenes, Valdecir [UNESP]
dc.contributor.authorFraceto, Leonardo Fernandes [UNESP]
dc.contributor.authorMalacrida Mayer, Cassia Roberta [UNESP]
dc.contributor.authorRibeiro-Paes, João Tadeu [UNESP]
dc.contributor.authorFerreira, Fernando Yutaka de [UNESP]
dc.contributor.authorZoppe, Natália Alves [UNESP]
dc.contributor.authorSantos, Lucinéia dos [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionNossa Senhora do Patrocínio Faculty Center—CEUNSP
dc.date.accessioned2023-07-29T13:48:48Z
dc.date.available2023-07-29T13:48:48Z
dc.date.issued2023-03-01
dc.description.abstractCaryocar brasiliense Cambess is a plant species typical of the Cerrado, a Brazilian biome. The fruit of this species is popularly known as pequi, and its oil is used in traditional medicine. However, an important factor hindering the use of pequi oil is its low yield when extracted from the pulp of this fruit. Therefore, in this study, with aim of developing a new herbal medicine, we an-alyzed the toxicity and anti-inflammatory activity of an extract of pequi pulp residue (EPPR), fol-lowing the mechanical extraction of the oil from its pulp. For this purpose, EPPR was prepared and encapsulated in chitosan. The nanoparticles were analyzed, and the cytotoxicity of the encapsu-lated EPPR was evaluated in vitro. After confirming the cytotoxicity of the encapsulated EPPR, the following evaluations were performed with non-encapsulated EPPR: in vitro anti-inflammatory activity, quantification of cytokines, and acute toxicity in vivo. Once the anti-inflammatory activity and absence of toxicity of EPPR were verified, a gel formulation of EPPR was developed for topical use and analyzed for its in vivo anti-inflammatory potential, ocular toxicity, and previous stability assessment. EPPR and the gel containing EPPR showed effective anti-inflammatory activity and lack of toxicity. The formulation was stable. Thus, a new herbal medicine with anti-inflammatory activity can be developed from discarded pequi residue.en
dc.description.affiliationSchool of Dentistry São Paulo State University (UNESP)
dc.description.affiliationDepartment of Biotechnology School of Sciences and Languages São Paulo State University (UNESP)
dc.description.affiliationDepartment of Biotechnology and Bioprocesses Engineering School of Pharmaceutical Sciences São Paulo State University (UNESP)
dc.description.affiliationDepartment of Genetics Ribeirão Preto Medical School University of São Paulo
dc.description.affiliationNossa Senhora do Patrocínio Faculty Center—CEUNSP
dc.description.affiliationDepartment of Biology School of Sciences and Languages São Paulo State University (UNESP)
dc.description.affiliationInstitute of Science and Technology of Sorocaba São Paulo State University (UNESP)
dc.description.affiliationDepartment of Biochemistry and Chemical Technology Institute of Chemistry São Paulo State University (UNESP)
dc.description.affiliationDepartment of Chemistry Faculty of Sciences São Paulo State University (UNESP)
dc.description.affiliationUnespSchool of Dentistry São Paulo State University (UNESP)
dc.description.affiliationUnespDepartment of Biotechnology School of Sciences and Languages São Paulo State University (UNESP)
dc.description.affiliationUnespDepartment of Biotechnology and Bioprocesses Engineering School of Pharmaceutical Sciences São Paulo State University (UNESP)
dc.description.affiliationUnespDepartment of Biology School of Sciences and Languages São Paulo State University (UNESP)
dc.description.affiliationUnespInstitute of Science and Technology of Sorocaba São Paulo State University (UNESP)
dc.description.affiliationUnespDepartment of Biochemistry and Chemical Technology Institute of Chemistry São Paulo State University (UNESP)
dc.description.affiliationUnespDepartment of Chemistry Faculty of Sciences São Paulo State University (UNESP)
dc.identifierhttp://dx.doi.org/10.3390/gels9030234
dc.identifier.citationGels, v. 9, n. 3, 2023.
dc.identifier.doi10.3390/gels9030234
dc.identifier.issn2310-2861
dc.identifier.scopus2-s2.0-85151451617
dc.identifier.urihttp://hdl.handle.net/11449/248611
dc.language.isoeng
dc.relation.ispartofGels
dc.sourceScopus
dc.subjectCerrado
dc.subjectinflammation
dc.subjectnanotechnology
dc.subjectpequi
dc.subjectphytotherapic
dc.titleAnti-Inflammatory Effect and Toxicological Profile of Pulp Residue from the Caryocar Brasiliense, a Sustainable Raw Materialen
dc.typeArtigo
unesp.author.orcid0000-0002-3903-2988[3]
unesp.author.orcid0000-0002-0733-1975[4]
unesp.author.orcid0000-0002-2827-2038[11]
unesp.author.orcid0000-0003-0069-6581[12]

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