Pharmacokinetic study of enrofloxacin in Nile tilapia (Oreochromis niloticus) after a single oral administration in medicated feed

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dc.contributor.authorTeles, J. A.
dc.contributor.authorCastello Branco, L. C.
dc.contributor.authorDel Bianchi, M.
dc.contributor.authorPilarski, F. [UNESP]
dc.contributor.authorReyes, F. G. R.
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-11-26T16:27:57Z
dc.date.available2018-11-26T16:27:57Z
dc.date.issued2016-04-01
dc.description.abstractThe objective of this study was to evaluate the disposition kinetics of enrofloxacin (ENR) in the plasma and its distribution in the muscle tissue of Nile tilapia (Oreochromis niloticus) after a single oral dose of 10mg/kg body weight via medicated feed. The fish were kept at a temperature between 28 and 30 degrees C. The collection period was between 30min and 120h after administration of the drug. The samples were analyzed by high-performance liquid chromatography with a fluorescence detector (HPLC-FLD). The ENR was slowly absorbed and eliminated from the plasma (C-max = 1.24 +/- 0.37 g/mL; T-max =8h; T-1/2Ke=19.36h). ENR was efficiently distributed in the muscle tissue and reached maximum values (2.17 +/- 0.74g/g) after 8h. Its metabolite, ciprofloxacin (CIP), was detected and quantified in the plasma (0.004 +/- 0.005g/mL) and muscle (0.01 +/- 0.011g/g) for up to 48h. After oral administration, the mean concentration of ENR in the plasma was well above the minimum inhibitory concentrations (MIC50) for most bacteria already isolated from fish except for Streptococcus spp. This way the dose used in this study allowed for concentrations in the blood to treat the diseases of tilapia.en
dc.description.affiliationUniv Estadual Campinas, Dept Food Sci, Sch Food Engn, R Monteiro Lobato 80, BR-13083862 Campinas, SP, Brazil
dc.description.affiliationSao Paulo State Univ CAUNESP, Aquaculture Ctr, Jaboticabal, SP, Brazil
dc.description.affiliationUnespSao Paulo State Univ CAUNESP, Aquaculture Ctr, Jaboticabal, SP, Brazil
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdCAPES: 23038.003966/2013-08
dc.description.sponsorshipIdCNPq: 305390/2013-9
dc.format.extent205-208
dc.identifierhttp://dx.doi.org/10.1111/jvp.12257
dc.identifier.citationJournal Of Veterinary Pharmacology And Therapeutics. Hoboken: Wiley-blackwell, v. 39, n. 2, p. 205-208, 2016.
dc.identifier.doi10.1111/jvp.12257
dc.identifier.issn0140-7783
dc.identifier.urihttp://hdl.handle.net/11449/161299
dc.identifier.wosWOS:000371733600015
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofJournal Of Veterinary Pharmacology And Therapeutics
dc.relation.ispartofsjr0,700
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.titlePharmacokinetic study of enrofloxacin in Nile tilapia (Oreochromis niloticus) after a single oral administration in medicated feeden
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderWiley-Blackwell

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